Gs&agr; deficiency in the dorsomedial hypothalamus underlies obesity associated with Gs&agr; mutations

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Clinical Investigation

• Publication date

  2016-12-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI88622PMID 27991864PMCID PMC5272175
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gsα Deficiency in the Ventromedial Hypothalamus Enhances Leptin Sensitivity and Improves Glucose Homeostasis in Mice on a High-Fat Diet.

  2016cited by this paper
• Resting Energy Expenditure Is Decreased in Pseudohypoparathyroidism Type 1A.

  2016cited by this paper
• G(q/11)α and G(s)α mediate distinct physiological responses to central melanocortins.

  2015cited by this paper
• Autonomic regulation of brown adipose tissue thermogenesis in health and disease: potential clinical applications for altering BAT thermogenesis

  2014cited by this paper
• Central neural regulation of brown adipose tissue thermogenesis and energy expenditure.

  2014cited by this paper
• Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

  2014cited by this paper
• MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus

  2014cited by this paper
• Psychological stress activates a dorsomedial hypothalamus-medullary raphe circuit driving brown adipose tissue thermogenesis and hyperthermia.

  2014cited by this paper
• Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure

  2013cited by this paper
• Reduced insulin sensitivity in adults with pseudohypoparathyroidism type 1a.

  2013cited by this paper
• Gsα deficiency in the paraventricular nucleus of the hypothalamus partially contributes to obesity associated with Gsα mutations.

  2012cited by this paper
• Leptin Action in the Dorsomedial Hypothalamus Increases Sympathetic Tone to Brown Adipose Tissue in Spite of Systemic Leptin Resistance

  2011cited by this paper
• Leptin-Receptor-Expressing Neurons in the Dorsomedial Hypothalamus and Median Preoptic Area Regulate Sympathetic Brown Adipose Tissue Circuits

  2011cited by this paper
• Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation.

  2009cited by this paper
• Severe obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region.

  2008cited by this paper
• Body mass index differences in pseudohypoparathyroidism type 1a versus pseudopseudohypoparathyroidism may implicate paternal imprinting of Galpha(s) in the development of human obesity.

  2007cited by this paper
• Thermogenesis activated by central melanocortin signaling is dependent on neurons in the rostral raphe pallidus (rRPa) area.

  2007cited by this paper
• Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.

  2007cited by this paper
• Studies of the regulation and function of the Gsα gene Gnas using gene targeting technology

  2007cited by this paper
• Role of the central melanocortin circuitry in adaptive thermogenesis of brown adipose tissue.

  2007cited by this paper
• The central melanocortin system directly controls peripheral lipid metabolism.

  2007cited by this paper
• Physiology and Pharmacology of Temperature Regulation The dorsomedial hypothalamus : a new player in thermoregulation

  2006cited by this paper
• SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.

  2006cited by this paper
• Sim1 haploinsufficiency impairs melanocortin-mediated anorexia and activation of paraventricular nucleus neurons.

  2006cited by this paper
• Direct pyrogenic input from prostaglandin EP3 receptor‐expressing preoptic neurons to the dorsomedial hypothalamus

  2005cited by this paper
• Alternative Gnas gene products have opposite effects on glucose and lipid metabolism.

  2005cited by this paper
• Divergence of melanocortin pathways in the control of food intake and energy expenditure.

  2005cited by this paper
• A mouse model of albright hereditary osteodystrophy generated by targeted disruption of exon 1 of the Gnas gene.

  2005cited by this paper
• Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency.

  2005cited by this paper
• The topographical organization of neurons in the dorsal hypothalamic area that project to the spinal cord or to the nucleus raphé pallidus in the rat

  2004cited by this paper
• Medullary pathways mediating specific sympathetic responses to activation of dorsomedial hypothalamus.

  2004cited by this paper
• Hypothalamic Melanocortin System Regulates Sympathetic Nerve Activity in Brown Adipose Tissue

  2004cited by this paper
• Identification of Sympathetic Premotor Neurons in Medullary Raphe Regions Mediating Fever and Other Thermoregulatory Functions

  2004cited by this paper
• Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat

  2003cited by this paper
• Disinhibition of rostral raphe pallidus neurons increases cardiac sympathetic nerve activity and heart rate.

  2003cited by this paper
• Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.

  2003cited by this paper
• Stimulation and blockade of GABA(A) receptors in the raphe pallidus: effects on body temperature, heart rate, and blood pressure in conscious rats.

  2003cited by this paper
• The melanocortin receptors: lessons from knockout models.

  2002cited by this paper
• Tachycardia evoked by disinhibition of the dorsomedial hypothalamus in rats is mediated through medullary raphe

  2002cited by this paper
• Central melanocortin receptors regulate insulin action.

  2001cited by this paper
• The central melanocortin system can directly regulate serum insulin levels.

  2000cited by this paper
• Profound obesity associated with a balanced translocation that disrupts the SIM1 gene.

  2000cited by this paper
• Targeted disruption of the melanocortin-4 receptor results in obesity in mice.

  1997cited by this paper
• Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain.

  1994cited by this paper
• Frontiers in Computational Neuroscience

  year unknowncited by this paper

• Biased signaling in drug discovery and precision medicine.

  2025cites this paper
• The growing complexity of the control of the hypothalamic pituitary thyroid axis and brown adipose tissue by leptin.

  2025cites this paper
• A human obesity-associated MC4R mutation with defective Gq/11α signaling leads to hyperphagia in mice

  2024cites this paper
• gnas Knockdown Induces Obesity and AHO Features in Early Zebrafish Larvae

  2024cites this paper
• Age-related ciliopathy: Obesogenic shortening of melanocortin-4 receptor-bearing neuronal primary cilia.

  2024cites this paper
• Explorative research on glucolipid metabolism and levels of adipokines in pseudohypoparathyroidism type 1 patients

  2023cites this paper
• The Role of Genetic and Epigenetic GNAS Alterations in the Development of Early-Onset Obesity.

  2023cites this paper
• A Novel GNAS Mutation in a Patient with Ia Pseudohypoparathyroidism (iPPSD2) Phenotype

  2023cites this paper
• Parental Origin of Gsα Inactivation Differentially Affects Bone Remodeling in a Mouse Model of Albright Hereditary Osteodystrophy

  2021cites this paper
• Obesity, Metabolic Syndrome and Disorders of Energy Balance

  2021cites this paper
• GNAS, McCune–Albright syndrome, and GH-producing tumors

  2021cites this paper
• Hypothalamic GPCR Signaling Pathways in Cardiometabolic Control

  2021cites this paper
• Signal pathway analysis of selected obesity-associated melanocortin-4 receptor class V mutants.

  2020cites this paper
• Diseases resulting from defects in the G protein Gsα

  2020cites this paper
• GNAS, PDE4D, and PRKAR1A Mutations and GNAS Methylation Changes Are Not a Common Cause of Isolated Early-Onset Severe Obesity Among Finnish Children

  2020cites this paper
• Imprinted Genes and Hypothalamic Function

  2020cites this paper
• Recent advances in understanding the role of leptin in energy homeostasis

  2020cites this paper
• Discrete TrkB-expressing neurons of the dorsomedial hypothalamus regulate feeding and thermogenesis

  2020cites this paper
• Pseudohypoparathyroidism presenting in children at a tertiary hospital in Johannesburg, South Africa

  2020cites this paper
• Gqα/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.

  2020cites this paper
• Language delay and developmental catch-up would be a clinical feature of pseudohypoparathyroidism type 1A during childhood.

  2019cites this paper
• Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling

  2019cites this paper
• Obesity‐associated mutant melanocortin‐4 receptors with normal Gαs coupling frequently exhibit other discoverable pharmacological and biochemical defects

  2019cites this paper
• Management of pseudohypoparathyroidism

  2019cites this paper
• A Candidate-Gene Approach Identifies Novel Associations Between Common Variants in/Near Syndromic Obesity Genes and BMI in Pediatric and Adult European Populations

  2019cites this paper
• The melanocortin pathway and control of appetite-progress and therapeutic implications.

  2019cites this paper
• Pseudohypoparathyroidism

  2019cites this paper
• Hunger and Satiety Signaling: Modeling Two Hypothalamomedullary Pathways for Energy Homeostasis

  2018cites this paper
• The stimulatory G protein Gsα is required in melanocortin 4 receptor–expressing cells for normal energy balance, thermogenesis, and glucose metabolism

  2018cites this paper
• Genetic and Epigenetic Defects at the GNAS Locus Lead to Distinct Patterns of Skeletal Growth but Similar Early‐Onset Obesity

  2018cites this paper
• Multiple hormonal resistance and metabolic disorders in pseudogypoparatiosis

  2018cites this paper
• Genomic imprinting, growth and maternal–fetal interactions

  2018cites this paper
• Neuronal cAMP/PKA Signaling and Energy Homeostasis.

  2018cites this paper
• Disruption of brain-derived neurotrophic factor production from individual promoters generates distinct body composition phenotypes in mice.

  2018cites this paper
• Glucose Homeostasis and Energy Balance in Children With Pseudohypoparathyroidism.

  2018cites this paper
• GNAS mutations and heterotopic ossification.

  2017cites this paper
• Biased signaling at neural melanocortin receptors in regulation of energy homeostasis.

  2017cites this paper
• Central regulation of brown adipose tissue thermogenesis and energy homeostasis dependent on food availability

  2017cites this paper
• Disorders of GNAS Inactivation

  2017cites this paper
• Early-Onset Obesity: Unrecognized First Evidence for GNAS Mutations and Methylation Changes

  2017cites this paper