Fatal Encephalitis Caused by Cristoli Virus, an Emerging Orthobunyavirus, France

C. Rodriguez,G. Gricourt,M. Ndebi,V. Démontant,L. Poiteau,S. Burrel,D. Boutolleau,P. Woerther,V. Calvez,Sébastian Stroer,J. Pawlotsky

Published 2020 in Emerging Infectious Diseases

ABSTRACT

We report the discovery of a new orthobunyavirus, Cristoli virus, by means of shotgun metagenomics. The virus was identified in an immunodepressed patient with fatal encephalitis. Full-length genome sequencing revealed high-level expression of a virulence factor, possibly explaining the severity of the infection. The patient’s recent history suggests circulation in France.

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