Reverse-Phase Protein Array Profiling of Oropharyngeal Cancer and Significance of PIK3CA Mutations in HPV-Associated Head and Neck Cancer

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Clinical Cancer Research

• Publication date

  2014-03-05

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1158/1078-0432.CCR-13-2585PMID 24599934PMCID PMC4027970
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Proteomic analysis of oropharyngeal carcinomas reveals novel HPV‐associated biological pathways

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• Annual Report to the Nation on the Status of Cancer, 1975–2009, Featuring the Burden and Trends in Human Papillomavirus (HPV)–Associated Cancers and HPV Vaccination Coverage Levels

  2013cited by this paper
• Expression of EGFR, VEGF, and NOTCH1 Suggest Differences in Tumor Angiogenesis in HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinoma

  2013cited by this paper
• The Evolving Field of Human Papillomavirus Receptor Research: a Review of Binding and Entry

  2013cited by this paper
• Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.

  2013cited by this paper
• Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States

  2012cited by this paper
• Cellular Entry of Human Papillomavirus Type 16 Involves Activation of the Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway and Inhibition of Autophagy

  2012cited by this paper
• Human Papillomaviruses Recruit Cellular DNA Repair and Homologous Recombination Factors to Viral Replication Centers

  2012cited by this paper
• Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

  2011cited by this paper
• DNA Repair Biomarker Profiling of Head and Neck Cancer: Ku80 Expression Predicts Locoregional Failure and Death following Radiotherapy

  2011influential reference
• Activation of the Insulin-like Growth Factor-1 Receptor Induces Resistance to Epidermal Growth Factor Receptor Antagonism in Head and Neck Squamous Carcinoma Cells

  2011cited by this paper
• EGFR–PI3K–AKT–mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy

  2011cited by this paper
• The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

  2011cited by this paper
• The molecular biology of head and neck cancer

  2011cited by this paper
• PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor–positive breast cancer

  2010cited by this paper
• AMPK exerts dual regulatory effects on the PI3K pathway

  2010cited by this paper
• Screening: Four-kallikrein panel to reduce unnecessary prostate biopsy

  2010cited by this paper
• Targeted therapies: Activated PI3K/AKT confers resistance to trastuzumab but not lapatinib

  2010cited by this paper
• Human papillomavirus and survival of patients with oropharyngeal cancer.

  2010cited by this paper
• Signal Transducer and Activator of Transcription 3 (STAT3) Mediates Amino Acid Inhibition of Insulin Signaling through Serine 727 Phosphorylation*

  2009cited by this paper
• Genomic profiling identifies common HPV-associated chromosomal alterations in squamous cell carcinomas of cervix and head and neck

  2009cited by this paper
• Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma.

  2009cited by this paper
• Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices.

  2009cited by this paper
• AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.

  2009cited by this paper
• PIK3CA Mutations Predict Local Recurrences in Rectal Cancer Patients

  2009cited by this paper
• Phosphoinositide 3-Kinase Mutations in Breast Cancer: A “Good” Activating Mutation?

  2009cited by this paper
• PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer.

  2009cited by this paper
• PIK3CA Mutation Associates with Improved Outcome in Breast Cancer

  2009cited by this paper
• An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.

  2008cited by this paper
• Regulation of insulin receptor substrate‐1 expression levels by caveolin‐1

  2008cited by this paper
• RNAi-mediated chromatin silencing in fission yeast.

  2008cited by this paper
• Gene expression profiles in HPV‐infected head and neck cancer

  2007cited by this paper
• Integrative Genomic Analysis of Phosphatidylinositol 3′-Kinase Family Identifies PIK3R3 as a Potential Therapeutic Target in Epithelial Ovarian Cancer

  2007cited by this paper
• Phosphoinositide kinase-3 status associated with presence or absence of human papillomavirus in head and neck squamous cell carcinomas.

  2007cited by this paper
• Human papillomavirus genotypes among women with HIV: implications for research and prevention.

  2006cited by this paper
• mTOR and cancer: insights into a complex relationship

  2006cited by this paper
• AKT-independent Phosphorylation of TSC2 and Activation of mTOR and Ribosomal Protein S6 Kinase Signaling by Prostaglandin F2α*

  2006cited by this paper
• Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

  2006cited by this paper
• Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus

  2006influential reference
• Gene Expression Differences Associated with Human Papillomavirus Status in Head and Neck Squamous Cell Carcinoma

  2006cited by this paper
• Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

  2006cited by this paper
• Proteomic analysis of cell surface proteins from Clostridium difficile

  2005cited by this paper
• Mutant PIK3CA promotes cell growth and invasion of human cancer cells.

  2005cited by this paper
• TOR action in mammalian cells and in Caenorhabditis elegans.

  2004cited by this paper
• Oncogenic Mutations of PIK3CA in Human Cancers

  2004cited by this paper
• Oncogenic mutations of PIK3CA in human cancers.

  2004cited by this paper
• Prognostic factors and long‐term survivorship in patients with recurrent or metastatic carcinoma of the head and neck

  2004cited by this paper
• IGF-I regulates caveolin 1 and IRS1 interaction in caveolae.

  2004cited by this paper
• Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

  2003cited by this paper
• Human papillomavirus (HPV) DNA in tonsillar cancer: Clinical correlates, risk of relapse, and survival

  2000cited by this paper
• Expression of PCNA is associated with the presence of HPV DNA in skin warts

  1996cited by this paper
• E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway.

  1996cited by this paper
• Molecular biology of head and neck cancer.

  1994cited by this paper
• Send Orders of Reprints at Bspsaif@emirates.net.ae a Decade of Global Mrna and Mirna Profiling of Hpv-positive Cell Lines and Clinical Specimens

  year unknowncited by this paper

• Selection Criteria for De-Escalated Chemoradiotherapy for HPV-Related Oropharyngeal Cancer Based on Prognostic Biomarkers or Early Tumor Response to Therapy: A Narrative Review

  2026cites this paper
• Therapeutic options for human papillomavirus‐positive tonsil and base of tongue cancer

  2025cites this paper
• Molecular Mechanisms and Clinical Divergences in HPV-Positive Cervical vs. Oropharyngeal Cancers: A Critical Narrative Review

  2025cites this paper
• Impact of PI3K pathway alterations on response to immune checkpoint inhibitors in HPV-negative head and neck squamous cell carcinoma

  2024cites this paper
• HPV and coronary diseases in menopausal women: an integrative review

  2024cites this paper
• Human papillomavirus (HPV) load is higher in HPVDNA/p16 positive than in HPVDNA positive/p16 negative oropharyngeal squamous cell carcinoma but does not differ significantly between various subsites or correlate to survival.

  2024cites this paper
• DNA Damage Response Mechanisms in Head and Neck Cancer: Significant Implications for Therapy and Survival

  2023cites this paper
• The SGK3-Catalase antioxidant signaling axis drives cervical cancer growth and therapy resistance

  2023cites this paper
• Genetic Mutations Associated with Inflammatory Response Caused by HPV Integration in Oropharyngeal Squamous Cell Carcinoma

  2023cites this paper
• Assessment of the Mutation Profile of Tonsillar Squamous Cell Carcinomas Using Targeted Next-Generation Sequencing

  2023cites this paper
• EGFR pathway targeting drugs in head and neck cancer in the era of immunotherapy.

  2022cites this paper
• PIK3CA Gene Mutations in HNSCC: Systematic Review and Correlations with HPV Status and Patient Survival

  2022cites this paper
• Comprehensive Viral Genotyping Reveals Prognostic Viral Phylogenetic Groups in HPV16-Associated Squamous Cell Carcinoma of the Oropharynx.

  2022cites this paper
• Targeting mTOR as a Cancer Therapy: Recent Advances in Natural Bioactive Compounds and Immunotherapy

  2022cites this paper
• Reverse Phase Protein Arrays in cancer stem cells.

  2022cites this paper
• Worldwide Prevalence of PI3K-AKT-mTOR Pathway Mutations in Head and Neck Cancer: A Systematic Review and Meta-Analysis.

  2021cites this paper
• Cell death in head and neck cancer pathogenesis and treatment

  2021cites this paper
• The PI3K/Akt/mTORC signaling axis in head and neck squamous cell carcinoma: Possibilities for therapeutic interventions either as single agents or in combination with conventional therapies

  2021cites this paper
• Whole-Exome Sequencing of HPV Positive Tonsillar and Base of Tongue Squamous Cell Carcinomas Reveals a Global Mutational Pattern along with Relapse-Specific Somatic Variants

  2021cites this paper
• Insights of Cisplatin Resistance in Cervical Cancer: A Decision Making for Cellular Survival

  2021cites this paper
• Prognostic and Predictive Clinical and Biological Factors in HPV Malignancies.

  2021cites this paper
• Targeted Therapy as a Potential De-Escalation Strategy in Locally Advanced HPV-Associated Oropharyngeal Cancer: A Literature Review

  2021cites this paper
• Biology of the Radio- and Chemo-Responsiveness in HPV Malignancies.

  2021cites this paper
• Oropharyngeal Squamous Cell Carcinoma Treatment in the Era of Immune Checkpoint Inhibitors

  2021cites this paper
• Molecular Tumor Subtypes of HPV-Positive Head and Neck Cancers: Biological Characteristics and Implications for Clinical Outcomes

  2021cites this paper
• CX-4945 and siRNA-Mediated Knockdown of CK2 Improves Cisplatin Response in HPV(+) and HPV(−) HNSCC Cell Lines

  2021cites this paper
• Prognostic Markers and Driver Genes and Options for Targeted Therapy in Human-Papillomavirus-Positive Tonsillar and Base-of-Tongue Squamous Cell Carcinoma

  2021influential citation
• Genomic heterogeneity and copy number variant burden are associated with poor recurrence‐free survival and 11q loss in human papillomavirus‐positive squamous cell carcinoma of the oropharynx

  2021cites this paper
• Global Genome Demethylation Causes Transcription-Associated DNA Double Strand Breaks in HPV-Associated Head and Neck Cancer Cells

  2020cites this paper
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  2020cites this paper
• Utility of a Reverse Phase Protein Array to Evaluate Multiple Biomarkers in Diffuse Large B‐Cell Lymphoma

  2019cites this paper
• Clinical Development of Molecular Targeted Therapy in Head and Neck Squamous Cell Carcinoma

  2019cites this paper
• E6 Oncoproteins from High-Risk Human Papillomavirus Induce Mitochondrial Metabolism in a Head and Neck Squamous Cell Carcinoma Model

  2019cites this paper
• A global epidemic increase of an HPV‐induced tonsil and tongue base cancer – potential benefit from a pan‐gender use of HPV vaccine

  2019cites this paper
• PIK3CA mutation in HPV-associated OPSCC patients receiving deintensified chemoradiation.

  2019cites this paper
• Novel K6-K14 keratin fusion enhances cancer stemness and aggressiveness in oral squamous cell carcinoma

  2019cites this paper
• Novel genetic alterations and their impact on target therapy response in head and neck squamous cell carcinoma

  2019cites this paper
• Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck

  2019cites this paper
• An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma

  2019cites this paper
• HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis

  2018cites this paper
• Therapeutic Implications of the Genetic Landscape of Head and Neck Cancer.

  2018cites this paper
• Protein Expression in Tonsillar and Base of Tongue Cancer and in Relation to Human Papillomavirus (HPV) and Clinical Outcome

  2018cites this paper
• Upfront surgery versus definitive chemoradiotherapy in patients with human Papillomavirus-associated oropharyngeal squamous cell cancer.

  2018cites this paper
• The molecular landscape of head and neck cancer

  2018cites this paper
• Targeting phosphoinositide 3-kinase (PI3K) in head and neck squamous cell carcinoma (HNSCC)

  2018cites this paper
• National treatment times in oropharyngeal cancer treated with primary radiation or chemoradiation.

  2018cites this paper
• Advances in biomarkers and treatment strategies for HPV-associated head and neck cancer

  2018cites this paper
• Treatment Delays in Primarily Resected Oropharyngeal Squamous Cell Carcinoma: National Benchmarks and Survival Associations

  2018cites this paper
• High-Throughput Phosphorylation Screening and Validation through Ti(IV)-Nanopolymer Functionalized Reverse Phase Phosphoprotein Array.

  2018cites this paper
• HPV status in unknown primary head and neck cancer: Prognosis and treatment outcomes

  2018cites this paper
• Comparison of PI3K Pathway in HPV‐Associated Oropharyngeal Cancer With and Without Tobacco Exposure

  2018cites this paper
• TRAF3 and CYLD Gene Defects in HPV-Associated Head and Neck Cancer: Biomarker of Response and Indicator of Targets for New Therapies

  2018cites this paper
• Somatic Genome Variation: What it is and What it Means for Agriculture and Human Health

  2017cites this paper
• The Molecular Pathology of Head and Neck Squamous Cell Carcinoma

  2017cites this paper
• Demethylation Therapy as a Targeted Treatment for Human Papillomavirus–Associated Head and Neck Cancer

  2017cites this paper
• Human Papillomavirus and Potentially Relevant Biomarkers in Tonsillar and Base of Tongue Squamous Cell Carcinoma.

  2017cites this paper
• Upregulation of pAKT(Ser473) expression in progression of HPV‐positive oropharyngeal squamous cell carcinoma

  2017cites this paper
• Molecular Patterns and Biology of HPV-Associated HNSCC.

  2017cites this paper
• Pancancer modelling predicts the context-specific impact of somatic mutations on transcriptional programs

  2017cites this paper
• Role of the Akt/mTOR signaling pathway in human papillomavirus-associated nasal and sinonasal inverted papilloma

  2017cites this paper
• Novel biomarkers of nasopharyngeal carcinoma metastasis risk identified by reverse phase protein array based tumor profiling with consideration of plasma Epstein–Barr virus DNA load

  2017cites this paper
• TRAF3/CYLD mutations identify a distinct subset of human papillomavirus‐associated head and neck squamous cell carcinoma

  2017cites this paper
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  2016cites this paper
• Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas

  2016cites this paper
• Phase I Study of Apitolisib (GDC-0980), Dual Phosphatidylinositol-3-Kinase and Mammalian Target of Rapamycin Kinase Inhibitor, in Patients with Advanced Solid Tumors

  2016cites this paper
• Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis

  2016influential citation
• Increased radiosensitivity of HPV-positive head and neck cancers: Molecular basis and therapeutic perspectives.

  2015cites this paper
• Molecular Biology and Immunology of Head & Neck Cancer

  2015cites this paper
• Human Papillomavirus (HPV)-Associated Oropharyngeal Cancer

  2015cites this paper
• Emerging biomarkers in head and neck cancer in the era of genomics

  2015cites this paper
• MEK Inhibitor PD-0325901 Overcomes Resistance to PI3K/mTOR Inhibitor PF-5212384 and Potentiates Antitumor Effects in Human Head and Neck Squamous Cell Carcinoma

  2015cites this paper
• Targeting the PI3K Pathway in Head and Neck Squamous Cell Carcinoma.

  2015cites this paper
• Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma

  2015cites this paper
• HPV and Radiation Sensitivity

  2015cites this paper
• DNA double strand break repair defect and sensitivity to poly ADP-ribose polymerase (PARP) inhibition in human papillomavirus 16-positive head and neck squamous cell carcinoma

  2015cites this paper
• The role of the PI3K/Akt/mTOR signalling pathway in human cancers induced by infection with human papillomaviruses

  2015cites this paper
• Targeting the PI3 K-mTOR Signaling Circuitry in HPV-Associated Oral Malignancies: Novel Precision Molecular Therapies

  2015cites this paper
• Mutational Profile of HPV-Positive HNSCC

  2015cites this paper
• Molecular biology and immunology of head and neck cancer.

  2015cites this paper
• The challenge of blocking a wider family members of EGFR against head and neck squamous cell carcinomas.

  2015cites this paper
• Human Papillomavirus-Associated Oropharynx Cancer (HPV-OPC): Treatment Options

  2014cites this paper
• The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma

  2014cites this paper
• The translational significance of epithelial-mesenchymal transition in head and neck cancer

  2014cites this paper
• Sequencing the head and neck cancer genome: implications for therapy

  2014cites this paper
• mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations

  2014cites this paper
• Chapter 5 – Biologics and Their Interactions with Radiation

  2012cites this paper