Vascular endothelial growth factor-mediated activation of p38 is dependent upon Src and RAFTK/Pyk2

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Oncogene

• Publication date

  2004-02-12

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1207243PMID 14676843
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Raf‐1 is activated by the p38 mitogen‐activated protein kinase inhibitor, SB203580

  1999cited by this paper
• Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human.

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• Activation of p38 Mitogen-activated Protein Kinase by PYK2/Related Adhesion Focal Tyrosine Kinase-dependent Mechanism*

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• Negative Regulation of PYK2/Related Adhesion Focal Tyrosine Kinase Signal Transduction by Hematopoietic Tyrosine Phosphatase SHPTP1*

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• The transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 and VEGF.

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• Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability.

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• Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta.

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• A simplified system for generating recombinant adenoviruses.

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• Differential Regulation of Pyk2 and Focal Adhesion Kinase (FAK)

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• Elementary events of agonist-induced Ca2+ release in vascular endothelial cells.

  1997cited by this paper
• Signaling through focal adhesion kinase

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• p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

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• Endothelial apoptosis in Braf-deficient mice

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• Vascular endothelial growth factor stimulates protein kinase C-dependent phospholipase D activity in endothelial cells.

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• Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

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• Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

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• Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

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• Angiogenesis in cancer, vascular, rheumatoid and other disease

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• Cytosolic calcium changes in endothelial cells induced by a protein product of human gliomas containing vascular permeability factor activity.

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