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Disturbances across whole brain networks during reward anticipation in an abstinent addiction population

L. Nestor,J. Suckling,K. Ersche,A. Murphy,J. McGonigle,C. Orban,L. Paterson,L. Reed,E. Taylor,R. Flechais,Dana G. Smith,E. Bullmore,R. Elliott,B. Deakin,I. Rabiner,A. Hughes,B. Sahakian,T. Robbins,D. Nutt

Published 2020 in NeuroImage: Clinical

ABSTRACT

Graphical abstract Network based statistics (NBS) analyses detected a graph sub-network comprising 153 edges between 59 nodes of the connectome where the ADD group demonstrated significantly less connectivity compared with the CON group. These differences in connectivity were mostly intra-hemispheric (55%), the majority (38%) being in the right hemisphere. The anatomical distribution of these connectivity differences between the two groups involved frontal (insula, inferior frontal gyrus, orbitofrontal cortex), limbic-associated (anterior cingulate gyrus, thalamus), and striatal (accumbens, caudate, pallidum) regions. The connectivity differences reported in this ADD sample indicate alterations between cognitive, striatal and limbic-associated regions during reward anticipation that persist into extended abstinence.

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