Functional and structural characterization of factor Xa dimer in solution.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Biophysical Journal

• Publication date

  2009-02-04

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bpj.2008.10.013PMID 19186135PMCID PMC2716635
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thrombin

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  2008cited by this paper
• A phosphatidylserine binding site in factor Va C1 domain regulates both assembly and activity of the prothrombinase complex.

  2008cited by this paper
• Intermolecular interactions and characterization of the novel factor Xa exosite involved in macromolecular recognition and inhibition: crystal structure of human Gla-domainless factor Xa complexed with the anticoagulant protein NAPc2 from the hematophagous nematode Ancylostoma caninum.

  2007cited by this paper
• The phosphatidylserine binding site of the factor Va C2 domain accounts for membrane binding but does not contribute to the assembly or activity of a human factor Xa-factor Va complex.

  2005cited by this paper
• Efficient thrombin generation requires molecular phosphatidylserine, not a membrane surface.

  2005cited by this paper
• Phospholipid regulates the activation of factor X by tissue factor/factor VIIa (TF/VIIa) via substrate and product interactions.

  2005cited by this paper
• The Critical Role of the 185–189-Loop in the Factor Xa Interaction with Na+ and Factor Va in the Prothrombinase Complex*

  2004cited by this paper
• Structural basis of membrane binding by Gla domains of vitamin K–dependent proteins

  2003influential reference
• Effects of water soluble phosphotidylserine on bovine factor Xa: functional and structural changes plus dimerization.

  2003cited by this paper
• Identification of Distinct Sequences in Human Blood Coagulation Factor Xa and Prothrombin Essential for Substrate and Cofactor Recognition in the Prothrombinase Complex*

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• Role of procoagulant lipids in human prothrombin activation. 2. Soluble phosphatidylserine upregulates and directs factor X(a) to appropriate peptide bonds in prothrombin.

  2002cited by this paper
• Specificity of soluble phospholipid binding sites on human factor Xa.

  2002cited by this paper
• Soluble Phosphatidylserine Triggers Assembly in Solution of a Prothrombin-activating Complex in the Absence of a Membrane Surface*

  2002cited by this paper
• Localization of Phosphatidylserine Binding Sites to Structural Domains of Factor Xa *

  2002cited by this paper
• The Contribution of Factor Xa to Exosite-dependent Substrate Recognition by Prothrombinase*

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• Phosphatidylserine binding alters the conformation and specifically enhances the cofactor activity of bovine factor Va.

  2002cited by this paper
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• Definition of a Factor Va Binding Site in Factor Xa*

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• Activation of Human Prothrombin by Human Prothrombinase

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• Crystal structures of human factor Xa complexed with potent inhibitors.

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• Identification of a binding site for quaternary amines in factor Xa.

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• Estimation of protein secondary structure from circular dichroism spectra: comparison of CONTIN, SELCON, and CDSSTR methods with an expanded reference set.

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• Sodium binding site of factor Xa: role of sodium in the prothrombinase complex.

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• Identification of Basic Residues in the Heparin-binding Exosite of Factor Xa Critical for Heparin and Factor Va Binding*

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• Sequential changes in trace metal, metallothionein and calmodulin concentrations in healing skin wounds

  1999cited by this paper
• Unexpected binding mode of tick anticoagulant peptide complexed to bovine factor Xa.

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• Role of thrombin compared with factor Xa in the procoagulant activity of whole blood clots.

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  1994cited by this paper
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• Factor VIII and Factor V Membrane Bound Complexes.

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• Macromolecular Protein Complexes III: Structure and Function

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• Factor Xa dimerization competes with prothrombinase complex formation on platelet-like membrane surfaces.

  2015cites this paper
• Phosphatidylserine and FVa regulate FXa structure.

  2014cites this paper
• Factor IX oligomerization underlies reduced activity upon disruption of physiological conditions

  2014cites this paper
• Ca2+ switches the effect of PS-containing membranes on Factor Xa from activating to inhibiting: implications for initiation of blood coagulation.

  2014cites this paper
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  2014cites this paper
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