Effects of Dose-Delivery Time Structure on Biological Effectiveness for Therapeutic Carbon-Ion Beams Evaluated with Microdosimetric Kinetic Model

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Radiation Research

• Publication date

  2013-06-14

• Fields of study

  Medicine, Physics, Engineering

• Identifiers
  DOI 10.1667/RR3178.1PMID 23768075
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Review of Update Clinical Results of Carbon Ion Radiotherapy

  2012cited by this paper
• Optimization algorithm for overlapping-field plans of scanned ion beam therapy with reduced sensitivity to range and setup uncertainties

  2011cited by this paper
• A robust algorithm of intensity modulated proton therapy for critical tissue sparing and target coverage

  2011cited by this paper
• Performance of the NIRS fast scanning system for heavy-ion radiotherapy.

  2010cited by this paper
• Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model

  2010cited by this paper
• Quantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning.

  2010cited by this paper
• Multiple-energy operation with extended flattops at HIMAC

  2010cited by this paper
• The Relationship Between the Sensitivity of Cells to High-Energy Photons and the RBE of Particle Radiation used in Radiotherapy

  2009cited by this paper
• Field-size effect of physical doses in carbon-ion scanning using range shifter plates.

  2009cited by this paper
• Biological dose optimization with multiple ion fields

  2008cited by this paper
• Clinical Results of Carbon Ion Radiotherapy at NIRS.

  2007cited by this paper
• Cluster Effects within the Local Effect Model

  2007cited by this paper
• Optimization for fast-scanning irradiation in particle therapy.

  2007cited by this paper
• Dynamic intensity control system with RF-knockout slow-extraction in the HIMAC synchrotron

  2007cited by this paper
• Improvement of the local effect model (LEM)--implications of clustered DNA damage.

  2006cited by this paper
• Fast multifield optimization of the biological effect in ion therapy

  2006cited by this paper
• Microdosimetric Measurements and Estimation of Human Cell Survival for Heavy-Ion Beams

  2006cited by this paper
• Biological effects of intermittent radiation in cultured tumor cells: influence of fraction number and dose per fraction.

  2005cited by this paper
• Recovery from sublethal damage during intermittent exposures in cultured tumor cells: implications for dose modification in radiosurgery and IMRT.

  2004cited by this paper
• A Microdosimetric-Kinetic Model for the Effect of Non-Poisson Distribution of Lethal Lesions on the Variation of RBE with LET

  2003cited by this paper
• Carbon ion radiotherapy for stage I non-small cell lung cancer.

  2003cited by this paper
• Impact of prolonged fraction delivery times on tumor control: a note of caution for intensity-modulated radiation therapy (IMRT).

  2003cited by this paper
• The effect of fraction time in intensity modulated radiotherapy: theoretical and experimental evaluation of an optimisation problem.

  2003cited by this paper
• Requirement for Repair of DNA Double-Strand Breaks by Homologous Recombination in Split-Dose Recovery

  2001cited by this paper
• Respiratory gated irradiation system for heavy-ion radiotherapy.

  2000cited by this paper
• Inactivation of Aerobic and Hypoxic Cells from Three Different Cell Lines by Accelerated 3He-, 12C- and 20Ne-Ion Beams

  2000cited by this paper
• Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy.

  1999cited by this paper
• The linear-quadratic model and most other common radiobiological models result in similar predictions of time-dose relationships.

  1998cited by this paper
• A microdosimetric-kinetic theory of the dependence of the RBE for cell death on LET.

  1998cited by this paper
• Computation of cell survival in heavy ion beams for therapy

  1997cited by this paper
• Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy.

  1997cited by this paper
• A microdosimetric-kinetic model of cell death from exposure to ionizing radiation of any LET, with experimental and clinical applications.

  1996cited by this paper
• Track structure and the calculation of biological effects of heavy charged particles.

  1996cited by this paper
• A convenient extension of the linear-quadratic model to include redistribution and reoxygenation.

  1995cited by this paper
• A statistical theory of cell killing by radiation of varying linear energy transfer.

  1994cited by this paper
• [Carbon beam irradiation of monolayer cells].

  1993cited by this paper
• A linear-quadratic model of cell survival considering both sublethal and potentially lethal radiation damage.

  1991cited by this paper
• Lethal and potentially lethal lesions induced by radiation--a unified repair model.

  1986cited by this paper
• The repair-misrepair model in radiobiology: comparison to other models.

  1985cited by this paper
• Repair processes in radiation biology.

  1984cited by this paper
• Inactivation of human kidney cells by high-energy monoenergetic heavy-ion beams.

  1979cited by this paper
• A Generalized Formulation of Dual Radiation Action1

  1978cited by this paper
• Polymer Crystallization on Morphological Templates

  1972cited by this paper
• Radiological Physics Characteristics of the Extracted Heavy Ion Beams of the Bevatron

  1971cited by this paper
• Radiation response of mammalian cells grown in culture: III. Modification of X-ray survival of Chinese hamster cells by 5-bromodeoxyuridine

  1963cited by this paper
• Radiation response of mammalian cells grown in culture. 1. Repair of X-ray damage in surviving Chinese hamster cells.

  1960cited by this paper

• Robustness of LETd-optimized multi-ion therapy against range and setup uncertainties: evaluation and enhancement with carbon-, oxygen-, and neon-ion beams

  2026cites this paper
• Compensated biological effective dose in extended radiotherapy course via a time-modified linear quadratic model for biological adaptive radiotherapy.

  2025cites this paper
• Design of multi-ion therapy for head and neck cancers using carbon-, oxygen-, and neon-ion beams: potential efficacy against tumor hypoxia

  2025cites this paper
• Equivalent relative biological effectiveness for cell survival and micronuclei formation: insights from a biophysical approach

  2025cites this paper
• Radiobiological effect of delivery time in treatments of multiple brain metastases with robotic radiosurgery.

  2025cites this paper
• Biological adaptive radiotherapy for short‐time dose compensation in lung SBRT patients

  2025cites this paper
• Pioneering Change in Radiotherapy With Biological Adaptive Radiotherapy for Lung Volumetric Modulated Radiotherapy (VMAT) Patients.

  2025cites this paper
• Investigation of the Impact of Temporal Dose Delivery Patterns of Ion Irradiation with the Local Effect Model

  2024influential citation
• Validation of the generalized stochastic microdosimetric model (GSM 2 ) over a broad range of LET and particle beam type: a unique model for accurate description of (therapy relevant) radiation qualities

  2024cites this paper
• Dose compensation for decreased biological effective dose due to intrafractional interruption during radiotherapy: integration with a commercial treatment planning system

  2024cites this paper
• Dosimetric analysis of six whole-breast irradiation techniques in supine and prone positions

  2024cites this paper
• Modeling of the resensitization effect on carbon-ion radiotherapy for stage I non-small cell lung cancer

  2024cites this paper
• Cell Survival Computation via the Generalized Stochastic Microdosimetric Model (GSM2); Part II: Numerical Results

  2024cites this paper
• Integrating microdosimetric in vitro RBE models for particle therapy into TOPAS MC using the MicrOdosimetry-based modeliNg for RBE ASsessment (MONAS) tool

  2023cites this paper
• A spatial measure-valued model for radiation-induced DNA damage kinetics and repair under protracted irradiation condition

  2023cites this paper
• Clonogenic Survival RBE Calculations in Carbon Ion Therapy: The Importance of the Absolute Values of α and β in the Photon Dose-Response Curve and a Strategy to Mitigate Their Anticorrelation

  2023cites this paper
• On the Emergence of the Deviation from a Poisson Law in Stochastic Mathematical Models for Radiation-Induced DNA Damage: A System Size Expansion

  2023cites this paper
• Mathematical model combined with microdosimetric kinetic model for tumor volume calculation in stereotactic body radiation therapy

  2023cites this paper
• Impact of DNA Repair Kinetics and Dose Rate on RBE Predictions in the UNIVERSE

  2022cites this paper
• Tumor radioresistance caused by radiation-induced changes of stem-like cell content and sub-lethal damage repair capability

  2022cites this paper
• Modelling the HPRT mutation induction of particle beams: systematic in vitro data collection, analysis and MKM implementation.

  2022cites this paper
• Multiple levels of stochasticity accounted for in different radiation biophysical models: from physics to biology

  2022influential citation
• The Dependence of Compensation Dose on Systematic and Random Interruption Treatment Time in Radiation Therapy

  2022cites this paper
• Modelling the HPRT-gene mutation induction of particle beams: systematic in vitro data collection, analysis and microdosimetric kinetic model implementation

  2022cites this paper
• Biological Dose Optimization for Particle Arc Therapy using Helium and Carbon Ions.

  2022cites this paper
• Adaptation of stochastic microdosimetric kinetic model to hypoxia for hypo-fractionated multi-ion therapy treatment planning

  2021cites this paper
• Generalized stochastic microdosimetric model: The main formulation.

  2021cites this paper
• Cell Survival Computation via the Generalized Stochastic Microdosimetric Model (GSM2); Part I: The Theoretical Framework

  2021cites this paper
• Impact of a spatially dependent dose delivery time structure on the biological effectiveness of scanning proton therapy.

  2021cites this paper
• Linking Microdosimetric Measurements to Biological Effectiveness in Ion Beam Therapy: A Review of Theoretical Aspects of MKM and Other Models

  2021cites this paper
• Radiobiological effects of the interruption time in radiation therapy with photon beams based on the microdosimetric kinetic model

  2020cites this paper
• Experimental validation of stochastic microdosimetric kinetic model for multi-ion therapy treatment planning with helium-, carbon-, oxygen-, and neon-ion beams

  2020cites this paper
• A theoretical cell-killing model to evaluate oxygen enhancement ratios at DNA damage and cell survival endpoints in radiation therapy

  2020cites this paper
• Dose compensation based on biological effectiveness due to interruption time for photon radiation therapy.

  2020cites this paper
• A Model for Estimating Dose-Rate Effects on Cell-Killing of Human Melanoma after Boron Neutron Capture Therapy

  2020cites this paper
• Robust radiobiological optimization of ion beam therapy utilizing Monte Carlo and microdosimetric kinetic model

  2020cites this paper
• The impact of dose delivery time on biological effectiveness in proton irradiation with various biological parameters.

  2020cites this paper
• Linking microdosimetric measurements to biological effectiveness: a review of theoretical aspects of MKM and other models

  2020cites this paper
• The Generalized Stochastic Microdosimetric Model: the main formulation.

  2020cites this paper
• Radiobiological effects of the interruption time with Monte Carlo Simulation on multiple fields in photon beams

  2020cites this paper
• Biological dose-enhancement analysis with Monte Carlo simulation for Lipiodol for photon beams.

  2019cites this paper
• Intensity Modulated Radiation Fields Induce Protective Effects and Reduce Importance of Dose-Rate Effects

  2019cites this paper
• Effect of Irradiation Time on Biological Effectiveness and Tumor Control Probability in Proton Therapy.

  2019cites this paper
• Title Microdosimetric Modeling of Biological Effectiveness for Boron Neutron Capture Therapy Considering Intra-and Intercellular Heterogeneity in 10 B Distribution

  2019cites this paper
• Report of the AAPM TG-256 on the relative biological effectiveness of proton beams in radiation therapy.

  2019influential citation
• DOSE-RATE AND CELL-KILLING SENSITIVITY OF HIGH-LINEAR ENERGY TRANSFER ION BEAM.

  2019cites this paper
• Integrated Modelling of Cell Responses after Irradiation for DNA-Targeted Effects and Non-Targeted Effects

  2018cites this paper
• Advances in Particle Therapy: A Multidisciplinary Approach

  2018cites this paper
• Report of a National Cancer Institute special panel: Characterization of the physical parameters of particle beams for biological research

  2018cites this paper
• A comparison of mechanism‐inspired models for particle relative biological effectiveness (RBE)

  2018cites this paper
• Relative biological effectiveness study of Lipiodol based on microdosimetric-kinetic model.

  2018cites this paper
• Investigation of dose-rate effects and cell-cycle distribution under protracted exposure to ionizing radiation for various dose-rates

  2018cites this paper
• Adaptation of stochastic microdosimetric kinetic model for charged-particle therapy treatment planning

  2018cites this paper
• Microdosimetric Modeling of Biological Effectiveness for Boron Neutron Capture Therapy Considering Intra- and Intercellular Heterogeneity in 10B Distribution

  2018cites this paper
• A Monte Carlo approach to the microdosimetric kinetic model to account for dose rate time structure effects in ion beam therapy with application in treatment planning simulations

  2017cites this paper
• Validation of the physical and RBE-weighted dose estimator based on PHITS coupled with a microdosimetric kinetic model for proton therapy

  2017cites this paper
• Markov chain Monte Carlo analysis for the selection of a cell‐killing model under high‐dose‐rate irradiation

  2017cites this paper
• Treatment planning of intensity modulated composite particle therapy with dose and linear energy transfer optimization

  2017cites this paper
• Corrigendum: A Simpler Energy Transfer Efficiency Model to Predict Relative Biological Effect for Protons and Heavier Ions

  2016cites this paper
• Biological dose representation for carbon-ion radiotherapy of unconventional fractionation

  2016cites this paper
• Adaptation of the microdosimetric kinetic model to hypoxia

  2016cites this paper
• Modeling cell survival and change in amount of DNA during protracted irradiation

  2016cites this paper
• Modeling the biophysical effects in a carbon beam delivery line by using Monte Carlo simulations

  2016cites this paper
• Reformulation of a clinical-dose system for carbon-ion radiotherapy treatment planning at the National Institute of Radiological Sciences, Japan

  2015cites this paper
• A Simpler Energy Transfer Efficiency Model to Predict Relative Biological Effect for Protons and Heavier Ions

  2015cites this paper
• Nuclear-interaction correction of integrated depth dose in carbon-ion radiotherapy treatment planning

  2015cites this paper
• A trichrome beam model for biological dose calculation in scanned carbon-ion radiotherapy treatment planning

  2015cites this paper
• Effects of beam interruption time on tumor control probability in single-fractionated carbon-ion radiotherapy for non-small cell lung cancer

  2015cites this paper
• Biological systems: from water radiolysis to carbon ion radiotherapy

  2015cites this paper
• ENVISION European NoVel Imaging Systems for ION therapy D 5 . 8 Clinical significance report based on radiobiological modelling and recommendations for future biological QA studies

  2014cites this paper
• A Microdosimetric-Kinetic Model for Cell Killing by Protracted Continuous Irradiation II: Brachytherapy and Biologic Effective Dose

  2014cites this paper
• Model Assembly for Estimating Cell Surviving Fraction for Both Targeted and Nontargeted Effects Based on Microdosimetric Probability Densities

  2014cites this paper
• Evaluation of the cell survival curve under radiation exposure based on the kinetics of lesions in relation to dose-delivery time

  2014cites this paper
• Implementation of a triple Gaussian beam model with subdivision and redefinition against density heterogeneities in treatment planning for scanned carbon-ion radiotherapy

  2014cites this paper
• Simulations, Optimizations, and Microdosimetric Measurements of Beam Quality for Heavy-Ion Tumor Therapy. A charged (particle) issue.

  2013cites this paper