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Oxidative stress and miR-200c

A. Magenta,M. C. Florio,M. D'Agostino,S. Sileno

Published 2020 in Unknown venue

ABSTRACT

Abstract Reactive oxygen species (ROS) levels are generated consequently to aerobic metabolism and play an important role as second messengers within the cell. Insufficient scavenging or ROS production exacerbation impairs many biological processes. microRNAs (miRNAs) are short noncoding RNA molecules that play key role in cellular homeostasis and in the regulation of redox balance. miR-200 family has been demonstrated to increase upon ROS, and in particular, miR-200c is the member most induced in endothelial cells (ECs). It increases also upon different ROS stimuli and in different cells such as fibroblast, muscle cells, neuronal cells, and tumor cells. miR-200c increase in ECs elicits cell apoptosis and senescence; it decreases the expression of ROS scavengers upregulating ROS and inhibiting NO production. miR-200c upregulation has been linked to different pathophysiological conditions associated with ROS increase, such as aging, ischemia, diabetes, cardiac hypertrophy, nonalcoholic steatohepatitis, Duchenne muscle dystrophy, atherosclerosis, and familial hypercholesterolemia.

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