Modulation of membrane associated immunoglobulins of cultured human lymphoid cells by specific antibody.

Modulation of membrane associated immunoglobulins by specific antibodies was studied on lymphoid cells of established suspension cultures derived from four normal individuals. Changes in κ and µ surface immunoglobulins were monitored by the mixed antiglobulin reaction. Exposure to anti-κ antiserum led to rapid disappearance of both κ and µ antigen; exposure to anti-µ antiserum resulted in complete loss of µ antigen, while κ antigens were unaffected or only partially affected. Restoration of κ and µ antigens occurred from 3 to 12 hr. Monovalent antibody was unable to modulate surface κ immunoglobulins. Modulation would not occur at low temperature or in the presence of sodium azide.

• Publication year

  1973

• Venue

  Journal of Immunology

• Publication date

  1973-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.110.5.1325PMID 4735382
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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