Ex Vivo Models and Interpretation of Mechanistic Studies in Hidradenitis Suppurativa.

J. Frew,V. Piguet

Published 2020 in Journal of Investigative Dermatology

ABSTRACT

Current ex vivo and animal models of hidradenitis suppurativa (HS) display issues with fidelity and validity to human disease. Vossen et al.'s Transwell culture system holds potential to reliably assess mechanistic pathways in HS. Consideration of the sites of control tissue and comparison of the Transwell model against skin explant models would increase the validity of this method of inquiry.

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