SCIENCE@home

Growth Hormone Reprograms Macrophages toward an Anti-Inflammatory and Reparative Profile in an MAFB-Dependent Manner

Blanca Soler Palacios,Concha Nieto,P. Fajardo,Arturo González de la Aleja,Nuria Andrés,Ángeles Domínguez-Soto,P. Lucas,A. Cuenda,J. Rodríguez-Frade,C. Martínez-A,R. Villares,Á. Corbí,M. Mellado

Published 2020 in Journal of Immunology

ABSTRACT

Key Points GH reprograms inflammatory macrophages to an anti-inflammatory phenotype. GH modulates inflammation by altering activin A secretion and MAFB-dependent genes. Growth hormone (GH), a pleiotropic hormone secreted by the pituitary gland, regulates immune and inflammatory responses. In this study, we show that GH regulates the phenotypic and functional plasticity of macrophages both in vitro and in vivo. Specifically, GH treatment of GM-CSF–primed monocyte–derived macrophages promotes a significant enrichment of anti-inflammatory genes and dampens the proinflammatory cytokine profile through PI3K-mediated downregulation of activin A and upregulation of MAFB, a critical transcription factor for anti-inflammatory polarization of human macrophages. These in vitro data correlate with improved remission of inflammation and mucosal repair during recovery in the acute dextran sodium sulfate–induced colitis model in GH-overexpressing mice. In this model, in addition to the GH-mediated effects on other immune cells, we observed that macrophages from inflamed gut acquire an anti-inflammatory/reparative profile. Overall, these data indicate that GH reprograms inflammatory macrophages to an anti-inflammatory phenotype and improves resolution during pathologic inflammatory responses.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-79 of 79 references · Page 1 of 1

CITED BY

Showing 1-26 of 26 citing papers · Page 1 of 1