Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Journal of Medicinal Chemistry

• Publication date

  1995-09-29

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/JM00020A005PMID 7562925
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Emergence of azole drug resistance in Candida species from HIV-infected patients receiving prolonged fluconazole therapy for oral candidosis.

  1995cited by this paper
• Resistance of Candida species to fluconazole

  1995cited by this paper
• Correlation between in vitro and in vivo activity of antifungal agents against Candida species.

  1994cited by this paper
• Optically active antifungal azoles. I. Synthesis and antifungal activity of (2R,3R)-2-(2,4-difluorophenyl)-3-mercapto-1-(1H-1,2,4-triazol-1-yl)-2-b utanol and its stereoisomers.

  1993cited by this paper
• Sch 39304, a new antifungal agent: oral and topical treatment of vaginal and superficial infections.

  1993cited by this paper
• Antifungal susceptibility testing

  1993cited by this paper
• In vitro and in vivo activities of SCH 42427, the active enantiomer of the antifungal agent SCH 39304

  1992cited by this paper
• Effect of cyclodextrin on the pharmacology of antifungal oral azoles

  1992cited by this paper
• Systemically administered antifungal agents. A review of their clinical pharmacology and therapeutic applications.

  1992cited by this paper
• Triazole antifungals. IV. Synthesis and antifungal activities of 3-acylamino-2-aryl-2-butanol derivatives.

  1991cited by this paper
• Triazole antifungals. II. Synthesis and antifungal activities of 3-acyl-4-methyloxazolidine derivatives.

  1990cited by this paper
• Hypothesis on the molecular basis of the antifungal activity of N-substituted imidazoles and triazoles.

  1983cited by this paper
• Medical mycology in crisis.

  1983cited by this paper

• The Activity of FDA-Approved Prodrug Isavuconazonium Sulfate and Its Major Metabolite Isavuconazole Against Naegleria fowleri

  2026cites this paper
• Skeletal Editing through Molecular Recombination of 2H-Indazoles to Azo-Linked-Quinazolinones.

  2023cites this paper
• Ring-Strain-Enabled Catalytic Asymmetric Umpolung C-O Bond-Forming Reactions of 1,2-Oxazetidines for the Synthesis of Functionalized Chiral Ethers.

  2020cites this paper
• History of the development of antifungal azoles: A review on structures, SAR, and mechanism of action.

  2020cites this paper
• Reductive Fragmentation of Tetrazoles: Mechanistic Insights and Applications toward the Stereocontrolled Synthesis of 2,6-Polysubstituted Morpholines.

  2019cites this paper
• Recent Advances in Azole Based Scaffolds as Anticandidal Agents

  2019cites this paper
• Synthesis of New Azole and Azine Systems Based on Chromeno[3,4-c]pyrrole-3,4-dione and Investigation of Their Cytotoxic Activity

  2017cites this paper
• OUTCOME OF TREATMENT OF VULVOVAGINAL CANDIDIASIS IN AMINU KANO TEACHING HOSPITAL (AKTH); A RANDOMIZED CONTROLLED TRIAL OF TOPICAL CLOTRIMAZOLE VERSUS ORAL FLUCONAZOLE

  2017cites this paper
• Neutral tris(azolyl)phosphanes: An intriguing class of molecules in chemistry

  2016cites this paper
• Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors.

  2016cites this paper
• Metal–Organic Framework Based on Copper and Carboxylate-Imidazole as Robust and Effective Catalyst in the Oxidative Amidation of Carboxylic Acids and Formamides

  2016cites this paper
• Isolation of Metabolites and Screening for Antimicrobial Activity of Calodendrum Capense Thunb. (Rutaceae).

  2013cites this paper
• Iodine-induced regioselective direct alkylation of azoles via in situ formed alkyliodide

  2012cites this paper
• Diversity-Oriented Synthesis of Spiro- and Fused Azacycles from Ketone Molecular Templates

  2012cites this paper
• Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents.

  2010cites this paper
• Synthesis and biological activities of novel amine-derived bis-azoles as potential antibacterial and antifungal agents.

  2010cites this paper
• Simple and Efficient One Pot Synthetic Protocol to Construct Morpholin-2-ones.

  2010cites this paper
• Anhydro Sugars: Useful Tools for Chiral Syntheses of Heterocycles

  2007cites this paper
• Asymmetric synthesis, crystal structure, and antidepressant activity of 2-aryl-3-alkyl-5-methyl- 2-morpholinol hydrochlorides

  2007cites this paper
• Synthesis and antitumor activity of sulfur-containing 9-anilinoacridines.

  2005cites this paper
• Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues.

  2005cites this paper
• Clinically Promising New Triazoles for Systemic Fungal Infections

  2004cites this paper
• Design and synthesis of a diverse morpholine template library.

  2003cites this paper
• Voriconazole -- better chances for patients with invasive mycoses.

  2002cites this paper
• Treatment of murine cryptococcal meningitis with UR-9751 and UR-9746.

  2000cites this paper
• Optically active antifungal azoles. XI. An alternative synthetic route for 1.

  2000cites this paper
• Design and synthesis of potential inhibitors of the ergosterol biosynthesis as antifungal agents.

  2000cites this paper
• Systemic antifungal agents against AIDS-related opportunistic infections: current status and emerging drugs in development.

  1999cites this paper
• Current and Emerging Azole Antifungal Agents

  1999influential citation
• Triazolderivaten und Verfahren zur ihre Herstellung

  1998cites this paper
• New azole antifungals. 3. Synthesis and antifungal activity of 3-substituted-4(3H)-quinazolinones.

  1998cites this paper
• New azole antifungals. 2. Synthesis and antifungal activity of heterocyclecarboxamide derivatives of 3-amino-2-aryl-1-azolyl-2-butanol.

  1998cites this paper
• Dérives de Triazole et procédés pour leur préparation

  1998cites this paper
• In vitro antifungal activity of novel azole derivatives with a morpholine ring, UR-9746 and UR-9751, and comparison with fluconazole.

  1997cites this paper
• Efficacies of two novel azole derivatives each containing a morpholine ring, UR-9746 and UR-9751, against systemic murine coccidioidomycosis

  1997influential citation
• Synthesis of thiophenes and thieno[3,2-c]pyran-4-ones as antileishmanial and antifungal agents

  1997cites this paper
• Section Review Anti-infectives: Azole antifungal agents

  1996cites this paper
• SYNTHESIS AND ANTIFUNGAL ACTIVITY OF NEW AZOLE DERIVATIVES CONTAINING AN OXATHIANE RING

  1996cites this paper
• Synthesis and Antifungal Activity of New Azole Derivatives Containing an N-Acylmorpholine Ring.

  1996cites this paper
• Azole antifungal agents

  1996cites this paper
• Synthesis and biological activities of a novel class of azole-containing antifungal agents

  1996cites this paper