Genetic alterations in uterine fibroids – a new direction for pharmacological intervention?

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Expert opinion on therapeutic targets

• Publication date

  2015-08-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1517/14728222.2015.1075510PMID 26293838
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• MED12 exon 2 mutations in phyllodes tumors of the breast

  2015cited by this paper
• Clonally related uterine leiomyomas are common and display branched tumor evolution.

  2015cited by this paper
• Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast—implications for tumor biology and pathological diagnosis

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• Selective genetic analysis of myoma pseudocapsule and potential biological impact on uterine fibroid medical therapy

  2015cited by this paper
• Uterine Fibroids: Do We Deal With More Than One Disease?

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
• Correlated Expression of HMGA2 and PLAG1 in Thyroid Tumors, Uterine Leiomyomas and Experimental Models

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• Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma

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• Molecular topography of the MED12-deleted region in smooth muscle tumors: a possible link between non-B DNA structures and hypermutability

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• Identification of CUX1 as the recurrent chromosomal band 7q22 target gene in human uterine leiomyoma

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• Characterization of uterine leiomyomas by whole-genome sequencing.

  2013cited by this paper
• Mutation status of the mediator complex subunit 12 (MED12) in uterine leiomyomas and concurrent/metachronous multifocal peritoneal smooth muscle nodules (leiomyomatosis peritonealis disseminata)

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• Fibroid explants reveal a higher sensitivity against MDM2-inhibitor nutlin-3 than matching myometrium

  2012cited by this paper
• Ulipristal acetate versus leuprolide acetate for uterine fibroids.

  2012cited by this paper
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  2012cited by this paper
• t(12;13)(q14;q31) leading to HMGA2 upregulation in acute myeloid leukaemia

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  2012cited by this paper
• Mutational analysis of MED12 exon 2 in uterine leiomyoma and other common tumors

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• Ulipristal Acetate versus Placebo for Fibroid Treatment Before Surgery

  2012cited by this paper
• MED12 mutations in uterine fibroids—their relationship to cytogenetic subgroups

  2012cited by this paper
• Whole Exome Sequencing in a Random Sample of North American Women with Leiomyomas Identifies MED12 Mutations in Majority of Uterine Leiomyomas

  2012cited by this paper
• MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas

  2011influential reference
• MED12 exon 2 mutations are common in uterine leiomyomas from South African patients

  2011cited by this paper
• p14Arf acts as an antagonist of HMGA2 in senescence of mesenchymal stem cells—implications for benign tumorigenesis

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• Chromatin Immunoprecipitation to Analyze DNA Binding Sites of HMGA2

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• Comment re: HMGA2 is a negative regulator of DNA-PK pathway.

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• Cellular senescence in usual type uterine leiomyoma.

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• Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

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• New Directions in the Epidemiology of Uterine Fibroids

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• Overexpression of HMGA2 in uterine leiomyomas points to its general role for the pathogenesis of the disease

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  2009cited by this paper
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• Assessment of the clinical and molecular impact of different cytogenetic subgroups in a series of 272 lipomas with abnormal karyotype

  2007cited by this paper
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  2003cited by this paper
• Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

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• Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13).

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• HMGI-C and HMGI(Y) Immunoreactivity Correlates with Cytogenetic Abnormalities in Lipomas, Pulmonary Chondroid Hamartomas, Endometrial Polyps, and Uterine Leiomyomas and is Compatible with Rearrangement of the HMGI-C and HMGI(Y) Genes

  2000cited by this paper
• Dysregulation of HMGIC in a uterine lipoleiomyoma with a complex rearrangement including chromosomes 7, 12, and 14

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  1999cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• PAC clone containing the HMGI(Y) gene spans the breakpoint of a 6p21 translocation in a uterine leiomyoma cell line

  1996cited by this paper
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• A 6-Mb yeast artificial chromosome contig and long-range physical map encompassing the region on chromosome 12q15 frequently rearranged in a variety of benign solid tumors.

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• Deletions of both α5(IV) and α6(IV) collagen genes in Alport syndrome and in Alport syndrome associated with smooth muscle tumours

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1988cited by this paper
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• Clinical, laboratory and morphological parallels in the diagnosis of abnormal uterine bleeding

  2025cites this paper
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