Polymorphisms at the Paraoxonase 1 L55M and Q192R Loci Affect the Pathophysiology of Alzheimer’s Disease: Emphasis on the Cholinergic System and Beta-Amyloid Levels

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Neurodegenerative Diseases

• Publication date

  2008-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1159/000113709PMID 18322397
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Responsiveness to cholinesterase inhibitors in Alzheimer's disease: a possible role for the 192 Q/R polymorphism of the PON-1 gene.

  2005cited by this paper
• Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities

  2005cited by this paper
• Apolipoprotein E and Alzheimer's Disease A Role in Amyloid Catabolism

  2000cited by this paper
• Apolipoprotein E and β-amyloid levels in the hippocampus and frontal cortex of Alzheimer's disease subjects are disease-related and apolipoprotein E genotype dependent

  1999cited by this paper
• Comparative Alterations of Nicotinic and Muscarinic Binding Sites in Alzheimer's and Parkinson's Diseases

  1992cited by this paper

• Unveiling the Neuroprotective Effect of Paraoxonase 1 in Neurodegenerative Diseases Focusing on Alzheimer’s Disease

  2025cites this paper
• The Role of Age and Sex in Paraoxonase 1 Activity in Patients with Alzheimer's Dementia.

  2025cites this paper
• PON1 De ciency Promotes TREM2 Pathway- Mediated Microglial Phagocytosis and Inhibits Pro- In ammatory Cytokines Release in Vitro and in Vivo

  2021cites this paper
• Pon1 Deficiency Promotes Trem2 Pathway–Mediated Microglial Phagocytosis and Inhibits Pro-inflammatory Cytokines Release In Vitro and In Vivo

  2021cites this paper
• Paraoxonase Role in Human Neurodegenerative Diseases

  2020cites this paper
• PON1 de ciency promotes TREM2 pathway- mediated microglial phagocytosis and inhibits LPS- induced pro-in ammatory cytokines release

  2020cites this paper
• The link of organophosphorus pesticides with neurodegenerative and neurodevelopmental diseases based on evidence and mechanisms.

  2018cites this paper
• Association between dementia and vascular disease-associated polymorphisms in a Tunisian population

  2018cites this paper
• PON1 DNA methylation and neurobehavior in Mexican-American children with prenatal organophosphate exposure.

  2018cites this paper
• Profile of the Paraoxonase 1 (PON1) Gene 192Q/R Polymorphism and Clinical Associations among Older Singaporean Chinese with Alzheimer's and Mixed Dementia

  2016cites this paper
• Organophosphate pesticide exposure and neurodegeneration.

  2016cites this paper
• Alzheimer's and Parkinson's Diseases: Progress and New Perspectives

  2016cites this paper
• Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population

  2015cites this paper
• PON1 as a model for integration of genetic, epigenetic, and expression data on candidate susceptibility genes

  2015cites this paper
• Recent progress in the genetics and epigenetics of paraoxonase: why it is relevant to children's environmental health

  2015cites this paper
• Paraoxonase 1 in neurological disorders

  2014cites this paper
• Synergistic Epistasis of Paraoxonase 1 (rs662 and rs85460) and Apolipoprotein E4 Genes in Pathogenesis of Alzheimer’s Disease and Vascular Dementia

  2014influential citation
• Pharmacogenomics and Personalized Medicine in Alzheimer’s Disease

  2013cites this paper
• Linking pesticide exposure and dementia: what is the evidence?

  2013cites this paper
• Complexity of familial amyotrophic lateral sclerosis

  2012cites this paper
• The Past and Present of Paraoxonase Enzyme: Its Role in the Cardiovascular System and Some Diseases

  2012cites this paper
• THE PAST AND PRESENT OF PARAOXONASE ENZYME: ITS ROLE IN THE CARDIOVASCULAR SYSTEM AND SOME DISEASES PRO(LOST I SADA(NJOST ENZIMA PARAOKSONAZE: NJENA ULOGA U KARDIOVASKULARNOM SISTEMU I NEKIM BOLESTIMA

  2012cites this paper
• Serum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease.

  2012cites this paper
• Role of paraoxonase 1 (PON1) in organophosphate metabolism: implications in neurodegenerative diseases.

  2011cites this paper
• Paraoxonase 1 Gene Polymorphisms Do Not Influence the Response to Treatment in Alzheimer’s Disease

  2011cites this paper
• Paraoxonase Gene Polymorphism and the Risk for Alzheimer’s Disease in the Polish Population

  2011cites this paper
• Determinants of paraoxonase 1 status: genes, drugs and nutrition.

  2011cites this paper
• Genetic Polymorphism and Susceptibility to Pesticides

  2010cites this paper
• Paraoxonase 1 Polymorphisms Are Not Related with the Risk for Multiple Sclerosis

  2010cites this paper
• PON1 and Neurodevelopment in Children from the CHAMACOS Study Exposed to Organophosphate Pesticides in Utero

  2010cites this paper
• Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran.

  2010cites this paper
• The role of paraoxonase polymorphisms in the induction of micronucleus in paraoxon‐treated human lymphocytes

  2009cites this paper
• Genetic markers of neurodegeneration: a role for paraoxonase 1 in sporadic Alzheimer's disease?

  2009cites this paper
• Involvement of paraoxonase 1 genetic variants in Alzheimer’s disease neuropathology

  2009cites this paper
• Paraoxonase 1 activities and polymorphisms in autism spectrum disorders

  2008cites this paper
• Identification de déterminants génétiques impliqués dans la composante vasculaire de la MA, par analyses transcriptomiques, génétiques et moléculaires

  2008cites this paper