Translational Bioinformatics: Past, Present, and Future

Though a relatively young discipline, translational bioinformatics (TBI) has become a key component of biomedical research in the era of precision medicine. Development of high-throughput technologies and electronic health records has caused a paradigm shift in both healthcare and biomedical research. Novel tools and methods are required to convert increasingly voluminous datasets into information and actionable knowledge. This review provides a definition and contextualization of the term TBI, describes the discipline’s brief history and past accomplishments, as well as current foci, and concludes with predictions of future directions in the field.

• Publication year

  2016

• Venue

  Genomics, Proteomics & Bioinformatics

• Publication date

  2016-02-01

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1016/j.gpb.2016.01.003PMID 26876718PMCID 4792852
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans.

  2016cited by this paper
• Biochemical insights from population studies with genetics and metabolomics.

  2016cited by this paper
• A survey of current trends in computational drug repositioning

  2016cited by this paper
• Phenome-Wide Association Studies: Leveraging Comprehensive Phenotypic and Genotypic Data for Discovery

  2015cited by this paper
• Computational and experimental advances in drug repositioning for accelerated therapeutic stratification.

  2015cited by this paper
• Bringing the Common Rule into the 21st Century.

  2015cited by this paper
• Out of regulatory limbo, 23andMe resumes some health tests and hopes to offer more

  2015cited by this paper
• Brain disorders? Precisely

  2015cited by this paper
• Integrated systems approach identifies risk regulatory pathways and key regulators in coronary artery disease

  2015cited by this paper
• Integromic Analysis of Genetic Variation and Gene Expression Identifies Networks for Cardiovascular Disease Phenotypes

  2015cited by this paper
• Genotype-phenotype correlation in long QT syndrome

  2015cited by this paper
• A 'green button' for using aggregate patient data at the point of care.

  2014cited by this paper
• Enabling a genetically informed approach to cancer medicine: a retrospective evaluation of the impact of comprehensive tumor profiling using a targeted next-generation sequencing panel.

  2014cited by this paper
• Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist

  2014cited by this paper
• Actionable diagnosis of neuroleptospirosis by next-generation sequencing.

  2014cited by this paper
• PCORnet: turning a dream into reality

  2014cited by this paper
• Clinical interpretation and implications of whole-genome sequencing.

  2014cited by this paper
• Surveying Recent Themes in Translational Bioinformatics: Big Data in EHRs, Omics for Drugs, and Personal Genomics

  2014cited by this paper
• Response and acquired resistance to everolimus in anaplastic thyroid cancer.

  2014cited by this paper
• The MedSeq Project: a randomized trial of integrating whole genome sequencing into clinical medicine

  2014cited by this paper
• Design patterns for the development of electronic health record-driven phenotype extraction algorithms

  2014cited by this paper
• The Gut Microbiome: A New Frontier in Autism Research

  2013cited by this paper
• Evidence generating medicine: redefining the research-practice relationship to complete the evidence cycle.

  2013cited by this paper
• Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network

  2013cited by this paper
• Identifying Personal Genomes by Surname Inference

  2013cited by this paper
• A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors.

  2013cited by this paper
• Genomic Medicine: A Decade of Successes, Challenges, and Opportunities

  2013cited by this paper
• A sea of standards for omics data: sink or swim?

  2013cited by this paper
• Exploring the Pharmacogenomics Knowledge Base (PharmGKB) for Repositioning Breast Cancer Drugs by Leveraging Web Ontology Language (OWL) and Cheminformatics Approaches

  2013cited by this paper
• Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

  2013cited by this paper
• Electronic health records based phenotyping in next-generation clinical trials: a perspective from the NIH Health Care Systems Collaboratory.

  2013cited by this paper
• How the Patient-Centered Outcomes Research Institute is engaging patients and others in shaping its research agenda.

  2013cited by this paper
• A comparison of phenotype definitions for diabetes mellitus.

  2013cited by this paper
• Gut-brain axis: how the microbiome influences anxiety and depression.

  2013cited by this paper
• The changing privacy landscape in the era of big data

  2012cited by this paper
• The MURDOCK Study: a long-term initiative for disease reclassification through advanced biomarker discovery and integration with electronic health records.

  2012cited by this paper
• Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.

  2012cited by this paper
• An Altered Treatment Plan Based on Direct to Consumer (DTC) Genetic Testing: Personalized Medicine from the Patient/Pin-cushion Perspective

  2012cited by this paper
• Evidence-based medicine in the EMR era.

  2011cited by this paper
• Electronic Medical Records for Genetic Research: Results of the eMERGE Consortium

  2011cited by this paper
• Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies.

  2011cited by this paper
• Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

  2011cited by this paper
• Secondary Use of EHR: Data Quality Issues and Informatics Opportunities

  2010cited by this paper
• The $1,000 genome, the $100,000 analysis?

  2010cited by this paper
• Rethinking Randomized Clinical Trials for Comparative Effectiveness Research: The Need for Transformational Change

  2009cited by this paper
• Leadership Commitments to Improve Value in Health Care: Finding Common Ground: Workshop Summary

  2009cited by this paper
• Disclosure of APOE genotype for risk of Alzheimer's disease.

  2009cited by this paper
• Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

  2009cited by this paper
• The Connectivity Map: a new tool for biomedical research

  2007cited by this paper
• PharmGKB: a logical home for knowledge relating genotype to drug response phenotype

  2007cited by this paper
• Institute

  2006cited by this paper
• Finding Disease-Related Genomic Experiments Within an International Repository: First Steps in Translational Bioinformatics

  2006cited by this paper
• The role of serendipity in drug discovery

  2006cited by this paper

• HSPH1 and DNAJB1 as potential key regulators in hepatic ischemia-reperfusion injury.

  2026cites this paper
• In silico report on five high-risk protein C pathogenic variants: G403R, P405S, S421N, C238S, and I243T.

  2025cites this paper
• Understanding integrative approach of translational bioinformatics on cardiovascular disease: Myocardial Ischemia

  2024cites this paper
• Comprehensive Analysis of Sialylation-Related Gene Profiles and Their Impact on the Immune Microenvironment in Periodontitis

  2024cites this paper
• Human Health, Environmental Comfort, and Well-Being. Part 2. Ecological Comfort as a New and Strategic Factor in the Protection of Modern Human Health

  2024cites this paper
• The status quo and future prospects of digital twins for healthcare

  2024cites this paper
• Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2025

  2024cites this paper
• Investigating the structural and functional consequences of germline single nucleotide polymorphisms located in the genes of the alternative lengthening of telomere (ALT) pathway

  2024cites this paper
• Integrating Bioinformatics in Cervical Cancer Research: A Comprehensive Review

  2024cites this paper
• From genome to clinic: The power of translational bioinformatics in improving human health.

  2024cites this paper
• The Role of Genome-Wide Association Study in Pulmonary Disease Diagnostics: A Review in Medical Bioinformatics

  2024cites this paper
• Translational bioinformatics approach to combat cardiovascular disease and cancers.

  2024cites this paper
• Comprehensive characterization of coding and non-coding single nucleotide polymorphisms of the Myoneurin (MYNN) gene using molecular dynamics simulation and docking approaches

  2024cites this paper
• Computational Strategies in Nutrigenetics: Constructing a Reference Dataset of Nutrition-Associated Genetic Polymorphisms

  2023cites this paper
• Translational Bioinformatics Applied to the Study of Complex Diseases

  2023cites this paper
• Health 2050: faster cure via bioinformatics and quantified self; a design analysis

  2023cites this paper
• A gene regulatory network approach harmonizes genetic and epigenetic signals and reveals repurposable drug candidates for multiple sclerosis.

  2022cites this paper
• Translational Informatics for Natural Products as Antidepressant Agents

  2022cites this paper
• Recommendations of the International Medical Informatics Association (IMIA) on Education in Biomedical and Health Informatics: Second Revision

  2022cites this paper
• Translational Bioinformatics for Human Reproductive Biology Research: Examples, Opportunities and Challenges for a Future Reproductive Medicine

  2022cites this paper
• Massive proteogenomic reanalysis of publicly available proteomic datasets of human tissues in search for protein recoding via adenosine-to-inosine RNA editing

  2022cites this paper
• Systematic Identification of Genomic Markers for Guiding Iron Oxide Nanoparticles in Cervical Cancer Based on Translational Bioinformatics

  2022cites this paper
• In silico characterization of coding and non-coding SNPs of the androgen receptor gene

  2021cites this paper
• What Is Informatics?

  2021cites this paper
• Precision Medicine and a Learning Health System for Mental Health

  2021cites this paper
• Data Mining, Data Analytics, and Bioinformatics

  2021cites this paper
• Translational bioinformatics in healthcare: past, present, and future

  2021cites this paper
• Machine learning in translational bioinformatics

  2021cites this paper
• IoT applications in translational bioinformatics

  2021cites this paper
• A review of a hybrid IoT-NG-PON system for translational bioinformatics in healthcare

  2021cites this paper
• Role of Bioinformatics in cancer research and drug development

  2021cites this paper
• Translational bioinformatics methods for drug discovery and drug repurposing

  2021cites this paper
• Translational bioinformatics: An introduction

  2021cites this paper
• Discovery, Learning, and Experimentation With Artificial Intelligence-Based Tools at the Point of Care-Perils and Opportunity.

  2021cites this paper
• Translating Social Determinants of Health into Standardized Clinical Entities

  2020cites this paper
• Smart Healthcare: emerging technologies, best practices, and sustainable policies

  2020cites this paper
• Extensive In Silico Analysis of ATL1 Gene : Discovered Five Mutations That May Cause Hereditary Spastic Paraplegia Type 3A

  2020cites this paper
• Extensive In Silico Analysis of the Functional and Structural Consequences of SNPs in Human ARX Gene

  2020cites this paper
• The Community Oncology and Academic Medical Center Alliance in the Age of Precision Medicine: Cancer Genetics and Genomics Considerations

  2020cites this paper
• A modern era of personalized medicine in the diagnosis, prognosis, and treatment of prostate cancer

  2020cites this paper
• In silico analysis of the functional and structural consequences of SNPs in human ARX gene associated with EIEE1

  2020cites this paper
• Translational Bioinformatics Curricula in Graduate Biomedical Informatics Programs

  2020cites this paper
• Health 2050: Bioinformatics for Rapid Self-Repair; A Design Analysis for Future Quantified Self

  2020cites this paper
• Expanding the Understanding of the Heterogeneous Nature of Melanoma with Bioinformatics and Disorder-Based Proteomics.

  2019cites this paper
• Translational Bioinformatics: Informatics, Medicine, and -Omics

  2019cites this paper
• In Silico Genetics Revealing Novel Mutations in CEBPA Gene Associated with Acute Myeloid Leukemia

  2019cites this paper
• Identification of novel key biomarkers in Simpson-Golabi-Behmel Syndrome: Evidence from bioinformatics analysis

  2019cites this paper
• Technical, Biological, and Systems Barriers for Molecular Clinical Decision Support.

  2019cites this paper
• Comprehensive bioinformatics analysis of L1CAM gene revealed Novel Pathological mutations associated with L1 syndrome

  2019cites this paper
• In silico analysis of IDH3A gene revealed Novel mutations associated with Retinitis Pigmentosa

  2019cites this paper
• Metabolomics technology and bioinformatics for precision medicine

  2019cites this paper
• Extensive In Silico Analysis of ATL1 Gene: Discovered Five Mutations that may Cause Hereditary Spastic Paraplegia Type 3A

  2019cites this paper
• Therapies for rare diseases: therapeutic modalities, progress and challenges ahead

  2019cites this paper
• The Association between SLC25A15 Gene Polymorphisms and Hyperornithinemia-hyperammonemia-homocitrullinuria Syndrome: Using In Silico Analysis

  2019cites this paper
• In Silico Genetics Revealing 5 Mutations in CEBPA Gene Associated With Acute Myeloid Leukemia

  2019cites this paper
• Identification of Novel Key Biomarkers in Simpson-Golabi-Behmel Syndrome (SGBS)

  2019cites this paper
• PlatformTM, a standards-based data custodianship platform for translational medicine research

  2019cites this paper
• Bioinformatics Analysis and the Revelation of Thirteen Novel Mutations in Human LH-B Gene Related to PCOS

  2019cites this paper
• Secondary Metabolites: Metabolomics for Secondary Metabolites

  2019cites this paper
• Comprehensive Computational Analysis Revealed Thirteen Novel Mutations in Human FSH-B gene Related to PCOS

  2019cites this paper
• GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis

  2018cites this paper
• CCA based multi-view feature selection for multi-omics data integration

  2018cites this paper
• Postproceedings of the 9 th Annual International Conference on Biologically Inspired Cognitive Architec ures , BICA 2018 ( Nin h Annual M eting of the BICA Society ) Designing Artificial Cognitive Architectures : Brain Inspired or Biologically Inspired ?

  2018cites this paper
• ERASMUS+ PROGRAMME KEY ACTION 2: COOPERATION FOR INNOVATION AND THE EXCHANGE OF GOOD PRACTICES STRATEGIC PARTNERSHIPS IN THE FIELD OF EDUCATION, TRAINING AND YOUTH

  2018cites this paper
• Bioinformatics as Applied to Medicine: Challenges Faced Moving from Big Data to Smart Data to Wise Data

  2018cites this paper
• LA ATENCIÓN CLÍNICA DE LAS ENFERMEDADES RARAS: UN RETO PARA LA EDUCACIÓN MÉDICA

  2018cites this paper
• Reusing microarray clinical data from a complex disease with bioinformatics tool

  2018cites this paper
• New approach to generating insights for aging research based on literature mining and knowledge integration

  2017cites this paper
• EDITORIAL: Improving Neuropharmacology using Big Data, Machine Learning and Computational Algorithms

  2017cites this paper
• Integrated precision medicine: the role of electronic health records in delivering personalized treatment

  2017cites this paper
• Introduction: Translational Bioinformatics and Personalized Medicine

  2017cites this paper
• Challenges for learning health systems in the NHS. Case study: electronic health records in cardiology

  2017cites this paper
• P4 Medicine versus Hippocrates.

  2017cites this paper
• Medicine versus Hippocrates

  2017cites this paper
• A Review of Recent Advances in Translational Bioinformatics: Bridges from Biology to Medicine

  2017cites this paper
• Making sense of big data in health research: Towards an EU action plan

  2016cites this paper
• Importance of databases of nucleic acids for bioinformatic analysis focused to genomics

  2016cites this paper
• Erratum to: Making sense of big data in health research: towards an EU action plan

  2016cites this paper