The Promise, and Challenges, of Methods to Enhance the External Validity of Randomized Trial Results

Results from randomized trials do not necessarily apply to clinical practice, particularly if the trial sample and target population differ on factors that modify treatment effects. Happich et al. illustrate recently developed methods that may account for such differences when estimating population average treatment effects. In this commentary, we connect the paper to the broader literature on assessing and enhancing generalizability of trial results, and highlight the causal assumptions required to estimate target population effects.

• Publication year

  2020

• Venue

  Clinical pharmacology and therapy

• Publication date

  2020-07-21

• Fields of study

  Medicine, Psychology

• Identifiers
  DOI 10.1002/cpt.1992PMID 32691848PMCID PMC7669659
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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