Effects of Gasdermin D in Modulating Murine Lupus and its Associated Organ Damage

Gasdermin D (GSDMD) is the key executioner of an inflammatory cell death mechanism known as pyroptosis. Recent reports have also implicated GSDMD in other mechanisms of cell death, including apoptosis, necroptosis, and NETosis. Given the role of dysregulated cell death in autoimmune syndromes such as systemic lupus erythematosus (SLE), this study was undertaken in a murine lupus model to investigate whether GSDMD plays a pathogenic role in systemic autoimmunity by promoting inflammatory cell death, leading to increased generation of nuclear autoantigens and autoantibodies.

• Publication year

  2020

• Venue

  Arthritis & Rheumatology

• Publication date

  2020-07-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/art.41444PMID 32692482PMCID PMC8498992
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis

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• Caspase-1 initiates apoptosis in the absence of gasdermin D

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• Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

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• Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis

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• Mouse models of lupus: what they tell us and what they don’t

  2018cited by this paper
• Accelerated model of lupus autoimmunity and vasculopathy driven by toll-like receptor 7/9 imbalance

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• The Pore‐Forming Protein Gasdermin D Regulates Interleukin‐1 Secretion from Living Macrophages

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• Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

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• Noncanonical inflammasome signaling elicits gasdermin D–dependent neutrophil extracellular traps

  2018influential reference
• Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus.

  2018cited by this paper
• GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

  2018cited by this paper
• Gasdermin D Flashes an Exit Signal for IL-1.

  2018cited by this paper
• Caspase‐8: regulating life and death

  2017cited by this paper
• Pathogenesis of Diffuse Alveolar Hemorrhage in Murine Lupus

  2017cited by this paper
• Epithelial Cell Inflammasomes in Intestinal Immunity and Inflammation

  2017cited by this paper
• Diverse stimuli engage different neutrophil extracellular trap pathways

  2017cited by this paper
• Host DNases prevent vascular occlusion by neutrophil extracellular traps

  2017cited by this paper
• A distinct subset of plasmacytoid dendritic cells induces activation and differentiation of B and T lymphocytes

  2017cited by this paper
• Cardiovascular and Pulmonary Manifestations of Systemic Lupus Erythematosus.

  2017cited by this paper
• Live-cell visualization of gasdermin D-driven pyroptotic cell death

  2017cited by this paper
• Cell death in the pathogenesis of systemic lupus erythematosus and lupus nephritis.

  2017cited by this paper
• Corticosteroids in Lupus.

  2016cited by this paper
• The gasdermin-D pore: Executor of pyroptotic cell death

  2016cited by this paper
• Formation of membrane pores by gasdermin-N causes pyroptosis

  2016cited by this paper
• Why targeted therapies are necessary for systemic lupus erythematosus

  2016cited by this paper
• Systemic lupus erythematosus: Is it one disease?

  2016cited by this paper
• Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

  2015cited by this paper
• Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

  2015cited by this paper
• Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

  2015cited by this paper
• The role of neutrophils in the pathogenesis of systemic lupus erythematosus

  2015cited by this paper
• Interferon‐α and Angiogenic Dysregulation in Pregnant Lupus Patients Who Develop Preeclampsia

  2015cited by this paper
• Type I Interferon in the Pathogenesis of Lupus

  2014cited by this paper
• Epicutaneous Application of Toll‐like Receptor 7 Agonists Leads to Systemic Autoimmunity in Wild‐Type Mice: A New Model of Systemic Lupus Erythematosus

  2014cited by this paper
• A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus

  2013cited by this paper
• Role of neutrophils in systemic autoimmune diseases

  2013cited by this paper
• Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

  2012cited by this paper
• Pathogenic role of B-cells in the development of diffuse alveolar hemorrhage induced by pristane

  2011cited by this paper
• Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

  2011cited by this paper
• HMGB1 and RAGE in inflammation and cancer.

  2010cited by this paper
• HMGB proteins: interactions with DNA and chromatin.

  2010influential reference
• Acute fibrinous and organizing pneumonia in systemic lupus erythematosus: A case report and review of the literature

  2010cited by this paper
• Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

  2010cited by this paper
• Orphanet Journal of Rare Diseases BioMed Central Review

  2006cited by this paper
• Enhanced type I interferon signaling and recruitment of chemokine receptor CXCR3‐expressing lymphocytes into the skin following treatment with the TLR7‐agonist imiquimod

  2005cited by this paper
• Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood

  2003cited by this paper
• In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note

  1995cited by this paper
• [Erythematosus].

  1971cited by this paper

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• Nicotinamide boosts oocyte quantity and quality by promoting N4-acetylation modification in lupus mice

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• Sepsis‐induced NET formation requires MYD88 but is independent of GSDMD and PAD4

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• The Aconitate Decarboxylase 1/Itaconate Pathway Modulates Immune Dysregulation and Associates with Cardiovascular Disease Markers and Disease Activity in Systemic Lupus Erythematosus.

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• Lipopolysaccharide released from gut activates pyroptosis of macrophages via Caspase 11‐Gasdermin D pathway in systemic lupus erythematosus

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• Gasdermin D deficiency aborts myeloid calcium influx to drive granulopoiesis in lupus nephritis

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• STAT3 inhibition ameliorates renal interstitial inflammation in MRL/lpr mice with diffuse proliferative lupus nephritis

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• Necroptosis and autoimmunity.

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• The gasdermin family: emerging therapeutic targets in diseases

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• The aconitate decarboxylase 1/itaconate pathway modulates immune dysregulation and associates with cardiovascular disease markers in SLE

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• Unveiling the nexus: Decoding interactions between regulated cell death and systemic lupus erythematosus pathogenesis for innovative therapeutic avenues

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• Regulated cell death pathways in kidney disease

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• Disulfiram alleviates pristane-induced lupus via inhibiting GSDMD-mediated pyroptosis

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• Pathological mechanisms and crosstalk among different forms of cell death in systemic lupus erythematosus.

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• Pyroptosis and Its Role in Autoimmune Disease: A Potential Therapeutic Target

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• Bite of the wolf: innate immune responses propagate autoimmunity in lupus.

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• Association of serum Gasdermin D with anti‐N‐methyl‐D‐aspartate receptor encephalitis

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• Neutrophil Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus.

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• Channelling inflammation: gasdermins in physiology and disease

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• Neutrophils in the Pathogenesis of Rheumatic Diseases: Fueling the Fire

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