High affinity heparin detection by multivalent supramolecular polymers through aggregation induced emission.

Amphiphilic di-cationic cyanostilbene derivatives with aggregation induced emission (AIE) features formed luminescent supramolecular polymers in aqueous media. They bind bio-polyanion heparin, a known anticoagulant, in a multivalent fashion through the formation of co-assemblies with highly enhanced greenish-yellow emission. Heparin detection in nanomolar concentrations in buffer and in medically relevant concentrations in human serum and plasma was achieved.

• Publication year

  2020

• Venue

  Chemical Communications

• Publication date

  2020-07-21

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/d0cc03644gPMID 32691029
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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