Killing activity and rescue function of genome-wide toxin-antitoxin loci of Mycobacterium tuberculosis.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  FEMS Microbiology Letters

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.1574-6968.2008.01400.xPMID 19016878
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The mRNA interferases, MazF‐mt3 and MazF‐mt7 from Mycobacterium tuberculosis target unique pentad sequences in single‐stranded RNA

  2008cited by this paper
• The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins

  2007cited by this paper
• Two higBA loci in the Vibrio cholerae superintegron encode mRNA cleaving enzymes and can stabilize plasmids

  2006cited by this paper
• Characterization of mRNA Interferases from Mycobacterium tuberculosis*

  2006influential reference
• Induction of Escherichia coli Chromosomal mazEF by Stressful Conditions Causes an Irreversible Loss of Viability

  2006cited by this paper
• Toxin–antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes

  2005cited by this paper
• Prokaryotic toxin–antitoxin stress response loci

  2005cited by this paper
• Molecular basis of gyrase poisoning by the addiction toxin CcdB.

  2005cited by this paper
• Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM‐yoeB toxin‐antitoxin system

  2004cited by this paper
• Escherichia coli mazEF-Mediated Cell Death Is Triggered by Various Stressful Conditions

  2004cited by this paper
• Specialized Persister Cells and the Mechanism of Multidrug Tolerance in Escherichia coli

  2004cited by this paper
• The role of RelMtb-mediated adaptation to stationary phase in long-term persistence of Mycobacterium tuberculosis in mice

  2003cited by this paper
• The Escherichia coli mazEF Suicide Module Mediates Thymineless Death

  2003cited by this paper
• Genes required for mycobacterial growth defined by high density mutagenesis

  2003cited by this paper
• MazF cleaves cellular mRNAs specifically at ACA to block protein synthesis in Escherichia coli.

  2003cited by this paper
• The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site.

  2003cited by this paper
• Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling

  2002cited by this paper
• Mycobacterium tuberculosis Genes Induced during Infection of Human Macrophages

  2002cited by this paper
• Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins

  2002cited by this paper
• ParE toxin encoded by the broad‐host‐range plasmid RK2 is an inhibitor of Escherichia coli gyrase

  2002cited by this paper
• RelE, a global inhibitor of translation, is activated during nutritional stress

  2001cited by this paper
• Postsegregational Killing Mediated by the P1 Phage “Addiction Module” phd-doc Requires the Escherichia coli Programmed Cell Death SystemmazEF

  2001cited by this paper
• Molecular Cloning: A Laboratory Manual

  2001cited by this paper
• Addiction modules and programmed cell death and antideath in bacterial cultures.

  1999cited by this paper
• The interaction of the F plasmid killer protein, CcdB, with DNA gyrase: induction of DNA cleavage and blocking of transcription.

  1997cited by this paper
• Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter

  1995cited by this paper
• Programmed cell death in bacterial populations

  1995cited by this paper
• Programmed cell death in bacteria: proteic plasmid stabilization systems

  1995cited by this paper
• Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli.

  1995cited by this paper
• The parDE operon of the broad-host-range plasmid RK2 specifies growth inhibition associated with plasmid loss.

  1994cited by this paper
• Use of the tetracycline promoter for the tightly regulated production of a murine antibody fragment in Escherichia coli.

  1994cited by this paper
• Lon‐dependent proteolysis of CcdA is the key control for activation of CcdB in plasmid‐free segregant bacteria

  1994cited by this paper
• Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells.

  1986cited by this paper
• Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genes.

  1986influential reference
• The nucleotide sequences of the replication origins of plasmids ColA and ColD.

  1985cited by this paper

• RelK, a YoeB-like toxin from Mycobacterium tuberculosis displays ribosome independent endonucleolytic activity.

  2025cites this paper
• Ser/Thr phosphorylation of Mycobacterium tuberculosis type II RelK toxin by PknK destabilizes TA interaction and interferes with toxin neutralization

  2025cites this paper
• Are all VapC toxins of Mycobacterium tuberculosis endowed with enigmatic RNase activity?

  2024cites this paper
• Deciphering the role of VapBC toxin-antitoxin systems in Mycobacterium tuberculosis stress adaptation.

  2024cites this paper
• MazEF toxin–antitoxin systems: their role in Mycobacterium tuberculosis stress response and drug resistance

  2024cites this paper
• The Toxin of VapBC-1 Toxin-Antitoxin Module from Leptospira interrogans Is a Ribonuclease That Does Not Arrest Bacterial Growth but Affects Cell Viability

  2024cites this paper
• HigA2 (Rv2021c) Is a Transcriptional Regulator with Multiple Regulatory Targets in Mycobacterium tuberculosis

  2024cites this paper
• Deciphering the role of VapBC13 and VapBC26 toxin antitoxin systems in the pathophysiology of Mycobacterium tuberculosis

  2024cites this paper
• TB-ISATEST: a Diagnostic LAMP Assay for Differentiation of Mycobacterium tuberculosis

  2023cites this paper
• Insights into the solution structure and transcriptional regulation of the MazE9 antitoxin in Mycobacterium tuberculosis

  2023cites this paper
• Toxin-Antitoxin system of Mycobacterium tuberculosis: Roles beyond stress sensor and growth regulator.

  2023cites this paper
• Ser/Thr Phosphorylation of Mycobacterium tuberculosis Type II Rel TA module by Protein Kinase K interferes with toxin neutralization: A novel mode of TA regulation

  2023influential citation
• Disruption of MenT2 toxin impairs the growth of Mycobacterium tuberculosis in guinea pigs.

  2022cites this paper
• Functional and Biochemical Characterization of the MazEF6 Toxin-Antitoxin System of Mycobacterium tuberculosis

  2022cites this paper
• The Correlation Between the Persistence of Methicillin Resistant Staphylococcus Aureus Isolates to Mupirocine and Toxin-Antitoxin Type II Genes

  2022cites this paper
• Rapid Identification of Secondary Structure and Binding Site Residues in an Intrinsically Disordered Protein Segment

  2021cites this paper
• Chasing the structural diversity of the transcription regulator Mycobacterium tuberculosis HigA2

  2021cites this paper
• Reprogramming Mycobacterium tuberculosis CRISPR System for Gene Editing and Genome-wide RNA Interference Screening

  2021cites this paper
• HigB1 Toxin in Mycobacterium tuberculosis Is Upregulated During Stress and Required to Establish Infection in Guinea Pigs

  2021influential citation
• Biochemical Characterization of VapC46 Toxin from Mycobacterium tuberculosis

  2020cites this paper
• VapC21 Toxin Contributes to Drug-Tolerance and Interacts With Non-cognate VapB32 Antitoxin in Mycobacterium tuberculosis

  2020cites this paper
• Reprogramming the endogenous type III-A CRISPR-Cas system for genome editing, RNA interference and CRISPRi screening in Mycobacterium tuberculosis

  2020cites this paper
• Expression, purification and functional characterization of recombinant hypervariable region (HVR) of Chikungunya virus nsP3 protein

  2019cites this paper
• Toxin-Antitoxin (TA) Systems in Stress Survival and Pathogenesis

  2019cites this paper
• Hypoxia Is Not a Main Stress When Mycobacterium tuberculosis Is in a Dormancy-Like Long-Chain Fatty Acid Environment

  2019cites this paper
• System-Wide Analysis Unravels the Differential Regulation and In Vivo Essentiality of Virulence-Associated Proteins B and C Toxin-Antitoxin Systems of Mycobacterium tuberculosis

  2018cites this paper
• VapC proteins from Mycobacterium tuberculosis share ribonuclease sequence specificity but differ in regulation and toxicity

  2018cites this paper
• Mycobacterium tuberculosis toxin Rv2872 is an RNase involved in vancomycin stress response and biofilm development

  2018cites this paper
• Mechanisms of Bacterial Tolerance and Persistence in the Gastrointestinal and Respiratory Environments

  2018cites this paper
• Toxin-antitoxin systems and regulatory mechanisms in Mycobacterium tuberculosis.

  2018cites this paper
• Co-expression network analysis of toxin-antitoxin loci in Mycobacterium tuberculosis reveals key modulators of cellular stress

  2017cites this paper
• Running Title: tRNAs taking charge

  2016cites this paper
• tRNA is a new target for cleavage by a MazF toxin

  2016cites this paper
• Toxin-Antitoxin Systems in Clinical Pathogens

  2016cites this paper
• The SecB-like chaperone Rv1957 from Mycobacterium tuberculosis: crystallization and X-ray crystallographic analysis.

  2016cites this paper
• The GraTA toxin-antitoxin system of Pseudomonas putida: regulation and role in stress tolerance

  2016cites this paper
• Characterization of the genetic environment of blaESBL genes, integrons and toxin-antitoxin systems identified on large transferrable plasmids in multi-drug resistant Escherichia coli

  2015cites this paper
• tRNAs taking charge

  2015cites this paper
• The Mycobacterium tuberculosis relBE toxin:antitoxin genes are stress-responsive modules that regulate growth through translation inhibition

  2015cites this paper
• Host–pathogen interactome analysis of Chikungunya virus envelope proteins E1 and E2

  2015cites this paper
• MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs

  2015cites this paper
• Erratum to: The Mycobacterium tuberculosis relBE toxin: antitoxin genes are stress-responsive modules that regulate growth through translation inhibition

  2015cites this paper
• MAPPING INTERACTIONS OF CHIKUNGUNYA VIRUS STRUCTURAL PROTEINS Synopsis submitted in fulfillment of the requirements for the Degree of DOCTOR OF PHILOSOPHY

  2015cites this paper
• Time to Diagnosis and Persistence: The Two Major Determinants of Effective Tuberculosis Control

  2015influential citation
• Diversity of Mycobacterium tuberculosis across evolutionary 1 scales 2

  2015influential citation
• A new microarray platform for whole-genome expression profiling of Mycobacterium tuberculosis.

  2014cites this paper
• Toxin-Antitoxin Systems as Multilevel Interaction Systems

  2014cites this paper
• Rapid Restriction Enzyme-Free Cloning of PCR Products: A High-Throughput Method Applicable for Library Construction

  2014cites this paper
• VapC from the Leptospiral VapBC Toxin-Antitoxin Module Displays Ribonuclease Activity on the Initiator tRNA

  2014cites this paper
• Multitasking SecB chaperones in bacteria

  2014cites this paper
• Multiple Toxin-Antitoxin Systems in Mycobacterium tuberculosis

  2014cites this paper
• Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA

  2013cites this paper
• Structural overview of toxin-antitoxin systems in infectious bacteria: a target for developing antimicrobial agents.

  2013cites this paper
• The evolution of Mycobacterium tuberculosis dormancy models

  2013cites this paper
• Submitted in fulfilment of the requirements for the degree of DOCTOR OF PHILOSOPHY by KAPILA KUMAR 06401002

  2013cites this paper
• VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA

  2013cites this paper
• Toxin–antitoxin systems

  2013cites this paper
• Toxin-Antitoxin Loci in Mycobacterium tuberculosis

  2013cites this paper
• Identification and characterisation of toxin-antitoxin systems (TA) in Burkholderia pseudomallei

  2013cites this paper
• Type II Toxin-Antitoxins: Structural and Functional Aspects of Type II Loci in Mycobacteria

  2013cites this paper
• Proteomic profiling of the Mycobacterium tuberculosis identifies nutrient

  2013cites this paper
• Proteomic Profiling of Mycobacterium tuberculosis Identifies Nutrient-starvation-responsive Toxin–antitoxin Systems

  2013cites this paper
• Bioinformatic and Empirical Analysis of Novel Hypoxia-Inducible Targets of the Human Antituberculosis T Cell Response

  2012cites this paper
• Mapping interactions of Chikungunya virus nonstructural proteins.

  2012cites this paper
• Intraviral protein interactions of Chandipura virus

  2012cites this paper
• In vitro studies on the sputum phenotype of Mycobacterium tuberculosis

  2012cites this paper
• Human Antituberculosis T Cell Response Novel Hypoxia-Inducible Targets of the Bioinformatic and Empirical Analysis of

  2012cites this paper
• TAC from Mycobacterium tuberculosis: a paradigm for stress-responsive toxin–antitoxin systems controlled by SecB-like chaperones

  2012cites this paper
• SecB-like chaperone controls a toxin–antitoxin stress-responsive system in Mycobacterium tuberculosis

  2011cites this paper
• Expression and Characterization of Chandipura Virus Proteins

  2011cites this paper
• Regular Article Expression and Characterization of Chandipura Virus Proteins

  2011cites this paper
• Analysis of the role of VapBC-type toxin-antitoxin modules in growth, stress tolerance and drug tolerance in mycobacteria

  2011influential citation
• TubercuList e 10 years after

  2011cites this paper
• Toxin-Antitoxin Systems of Mycobacterium smegmatis Are Essential for Cell Survival*

  2011cites this paper
• The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array.

  2011cites this paper
• TubercuList--10 years after.

  2011cites this paper
• SecB-like chaperone controls a toxin-antitoxin stress-responsive system in Mycobacterium

  2011cites this paper
• VapC Toxins from Mycobacterium tuberculosis Are Ribonucleases that Differentially Inhibit Growth and Are Neutralized by Cognate VapB Antitoxins

  2011cites this paper
• The Biochemistry of VapBC Toxin-Antitoxins

  2011cites this paper
• Studies on in vitro human T cell reactivity to antigens of mycobacterium tuberculosis

  2010cites this paper
• Characterization of a chromosomal toxin-antitoxin, Rv1102c-Rv1103c system in Mycobacterium tuberculosis.

  2010influential citation
• The relBE2Spn Toxin-Antitoxin System of Streptococcus pneumoniae: Role in Antibiotic Tolerance and Functional Conservation in Clinical Isolates

  2010cites this paper
• Analyzing the Regulatory Role of the HigA Antitoxin within Mycobacterium tuberculosis

  2010cites this paper
• Letting sleeping dos lie: does dormancy play a role in tuberculosis?

  2010cites this paper
• The Yersinia pestis Chromosome Encodes Active Addiction Toxins

  2010cites this paper
• Duke University Dissertation Template

  2010cites this paper
• Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution

  2009cites this paper
• The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation.

  2009cites this paper
• Properties of mycobacterial vapBC toxin-antitoxin modules selected for study

  year unknowncites this paper