Evaluation of Oral administration of Methanolic Extract of Zingiber Dry Powder on Liver of Normal and Potassium Dichromate-Induced Hepatotoxic Rats

Background: Human exposure to Cr(VI) induces several adverse health effects,including liver damage.Ginger is a plant whose rhizome is used as a spice or folk medicine.The present study aimed to evaluate the effect of methanolic extract of Zingiber dry powder (ZME) administration on normal rat liver as well as potassium dichromate (PDC)-induced hepatotoxicity. Materials and Methods:24 rats were allocated in 4 groups (6 rats each): (I) control, (II)KCr group, injected with a single intraperitoneal injection of PDC(15mg\Kg bw), (III)ZME group dissolved in 10% tween20 (200mg\Kg bw) orally (VI)ZME+KCr group; Rats received ZME(200mg\Kg bw) for 7 days+ single injection with (15mg\Kg bw)then continuing ZME administration till day 10 and all animals from all groups were decapitated at 11 th day. Liver function indices in serum, oxidant/antioxidant parameters and inflammatory markers were determined in rat liver homogenate. Results: PDC increased AST and ALP liver functions with a significant change at p<0.05. ZME alone or with PDC ameliorated most elevated liver function parameters specially, AST and bilirubin at p<0.05, compared with control group. Livers homogenate of ZME treated rats showed altered oxidant/antioxidant status in a similar manner observed with KCr group. Administration of ZME to PDC injected ratsdecreased malonaldehydenonsignificantlyandameliorated SOD activitynonsignificantly versus control,while increased CAT activity at p<0.05 if compared to control, KCr and ZME groups. ZME aloneshowed signifigcant increase in IL-6 levels at p<0.05 and indicated a significant decrease at p<0.05 in the ZME+KCr if compared to ZME group and decreased TNF-α level with no significant changes in theircorresponding groups, when compared to control group. Histopathological examination of livers of ZME treated rats indicated edema, congestion, activated kupffer cells and necrotic hepatocytes. Conclusion: ginger powder should be used cautiously to normal and chromium-exposed individuals.

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