Photoredox-catalyzed sulfonylation of difluoroenoxysilanes with the insertion of sulfur dioxide.

A photoredox-catalyzed three-component reaction of aryldiazonium tetrafluoroborates with sodium metabisulfite and 2,2-difluoro enol silyl ethers is described. By using sodium metabisulfite as the source of sulfur dioxide, this method provides an elegant access to α,α-difluoro-β-ketosulfones in moderate to good yields under mild conditions, and features a broad substrate scope and wide functional group tolerance. Both of the difluoromethyl group and sulfone moiety can be introduced in a single step. Based on the experimental results, a single-electron transfer pathway is proposed with the insertion of sulfur dioxide.

• Publication year

  2020

• Venue

  Chemical Communications

• Publication date

  2020-08-19

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1039/d0cc03591bPMID 32812540
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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