The role of bone marrow derived-mesenchymal stem cells in attenuation of kidney function in rats with diabetic nephropathy

BackgroundStem cell therapy holds a great promise for the repair of injured tissues and organs, including the kidney. We studied the effect of mesenchymal stem cells (MSC) on experimental diabetic nephropathy (DN) in rats and the possible paracrine signals that mediate their action.Materials and methodsRats were divided into controls, DN rats, DN rats receiving MSCs. MSCs were given in a dose of (106cells) by intravenous injection. After 4 weeks, 24 h urinary albumin, serum urea and creatinine concentrations, transforming growth factor β (TGF β), tumor necrosis factor α (TNFα), B-cell lymphoma 2 (bcl2) and Bax gene expression and vascular endothelial growth factor (VEGF) were assessed. Histopathology staining was performed.ResultsMSC therapy significantly improved 24 h urinary albumin, serum urea and creatinine concentrations, increased angiogenic growth factor VEGF, and anti-apoptotic protein bcl2 while decreased the pro-inflammatory TNF-α, fibrogenic growth factor TGF β, and pro-apoptotic protein Bax. The histopathology examination showed patchy areas of minimal necrosis and degeneration in renal tubules.

• Publication year

  2014

• Venue

  Diabetology & Metabolic Syndrome

• Publication date

  2014-03-09

• Fields of study

  Medicine

• Identifiers
  DOI 10.1186/1758-5996-6-34PMID 24606996PMCID 4007638
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007cited by this paper
• Diabetic nephropathy: where hemodynamics meets metabolism.

  2007cited by this paper
• Leukocyte recruitment and vascular injury in diabetic nephropathy.

  2006cited by this paper
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  2005cited by this paper
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  2004influential reference
• From hyperglycemia to diabetic kidney disease: the role of metabolic, hemodynamic, intracellular factors and growth factors/cytokines.

  2004cited by this paper
• Effect of advanced glycation end-products on gene expression and synthesis of TNF-alpha and endothelial nitric oxide synthase by endothelial cells.

  2004cited by this paper
• Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis.

  2004cited by this paper
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  2004cited by this paper
• Tumor Necrosis Factor-&agr; Promotes Macrophage-Induced Vascular Smooth Muscle Cell Apoptosis by Direct and Autocrine Mechanisms

  2003cited by this paper
• Interleukin-10 inhibits ischemic and cisplatin-induced acute renal injury.

  2001cited by this paper
• Application of Bone Marrow-Derived Stem Cells in Experimental Nephrology

  2001cited by this paper
• Bone marrow contributes to renal parenchymal turnover and regeneration

  2001cited by this paper
• Glomerulosclerosis is transmitted by bone marrow-derived mesangial cell progenitors.

  2001cited by this paper
• Long-term treatment of focal segmental glomerulosclerosis in children with cyclosporine given as a single daily dose.

  2001cited by this paper
• Stem Cells Units of Development, Units of Regeneration, and Units in Evolution

  2000cited by this paper
• Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease

  2000cited by this paper
• Multilineage potential of adult human mesenchymal stem cells.

  1999cited by this paper
• Advanced glycation end products-cytokine-nitric oxide sequence pathway in the development of diabetic nephropathy: aminoguanidine ameliorates the overexpression of tumour necrosis factor-α and inducible nitric oxide synthase in diabetic rat glomeruli

  1999cited by this paper
• Regulation of TNF‐α‐induced reorganization of the actin cytoskeleton and cell‐cell junctions by Rho, Rac, and Cdc42 in human endothelial cells

  1998cited by this paper
• Involvement of tumor necrosis factor-alpha in the pathogenesis of experimental and human glomerulonephritis.

  1995cited by this paper
• Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

  1993cited by this paper
• Receptor-specific increase in extracellular matrix production in mouse mesangial cells by advanced glycosylation end products is mediated via platelet-derived growth factor.

  1992cited by this paper
• Interleukin 1-alpha and tumor necrosis factor-alpha induce oxygen radical production in mesangial cells.

  1990cited by this paper
• Interleukin 1-α and tumor necrosis factor-α induce oxygen radical production in mesangial cells

  1990cited by this paper
• Tumor necrosis factor induces glomerular damage in the rabbit.

  1989cited by this paper
• Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

  1988cited by this paper
• Tumor necrosis factor stimulates prostaglandin production and cyclic AMP levels in rat cultured mesangial cells

  1988cited by this paper
• Cachectin/TNF and IL-1 induced by glucose-modified proteins: role in normal tissue remodeling.

  1988cited by this paper

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