Resveratrol Antagonizes EGFR-Dependent Erk1/2 Activation in Human Androgen-Independent Prostate Cancer Cells with Associated Isozyme-Selective PKCα Inhibition

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Investigational new drugs

• Publication date

  2004-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1023/B:DRUG.0000011787.75522.ecPMID 14739659
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inhibition of angiogenesis by the antiepidermal growth factor receptor antibody ImClone C225 in androgen-independent prostate cancer growing orthotopically in nude mice.

  2002cited by this paper
• Food‐derived polyphenols inhibit pancreatic cancer growth through mitochondrial cytochrome C release and apoptosis

  2002cited by this paper
• Docetaxel in the integrated management of prostate cancer. Current applications and future promise.

  2002cited by this paper
• Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells.

  2001cited by this paper
• Resveratrol, a natural phenolic compound, inhibits cell proliferation and prevents oxidative DNA damage.

  2001cited by this paper
• A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol.

  2001cited by this paper
• Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.

  2001cited by this paper
• Inhibition of carcinogenesis by dietary polyphenolic compounds.

  2001cited by this paper
• Resveratrol causes WAF-1/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells.

  2001cited by this paper
• Role of Ceramide in Mediating the Inhibition of Telomerase Activity in A549 Human Lung Adenocarcinoma Cells*

  2001cited by this paper
• Transactivation of the Epidermal Growth Factor Receptor Is Involved in 12-O-Tetradecanoylphorbol-13-acetate-induced Signal Transduction*

  2001cited by this paper
• Anti-proliferative effect of resveratrol, a natural component of grapes and wine, on human colonic cancer cells.

  2000cited by this paper
• Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure.

  2000cited by this paper
• Regulation of Protein Kinase D by Multisite Phosphorylation

  2000cited by this paper
• Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines.

  2000cited by this paper
• Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation.

  2000cited by this paper
• Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase.

  2000cited by this paper
• From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells.

  1999cited by this paper
• Resveratrol preferentially inhibits protein kinase C-catalyzed phosphorylation of a cofactor-independent, arginine-rich protein substrate by a novel mechanism.

  1999cited by this paper
• Protein kinase C isoenzyme patterns characteristically modulated in early prostate cancer.

  1999cited by this paper
• New insights into the regulation of protein kinase C and novel phorbol ester receptors

  1999cited by this paper
• Activation of extracellular signal-regulated kinase in human prostate cancer.

  1999cited by this paper
• Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines.

  1999cited by this paper
• IMMUNOHISTOCHEMICAL COMPARATIVE ANALYSIS OF TRANSFORMING GROWTH FACTOR α, EPIDERMAL GROWTH FACTOR, AND EPIDERMAL GROWTH FACTOR RECEPTOR IN NORMAL, HYPERPLASTIC AND NEOPLASTIC HUMAN PROSTATES

  1999cited by this paper
• Characterization of Serine 916 as an in VivoAutophosphorylation Site for Protein Kinase D/Protein Kinase Cμ*

  1999cited by this paper
• Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines.

  1999cited by this paper
• Protein Kinase C Regulates Integrin-induced Activation of the Extracellular Regulated Kinase Pathway Upstream of Shc*

  1999cited by this paper
• Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells.

  1999cited by this paper
• Activation of mitogen-activated protein kinase associated with prostate cancer progression.

  1999cited by this paper
• Treatment options in androgen-independent prostate cancer.

  1999cited by this paper
• Immunohistochemical comparative analysis of transforming growth factor alpha, epidermal growth factor, and epidermal growth factor receptor in normal, hyperplastic and neoplastic human prostates.

  1999cited by this paper
• Antiproliferative effect of synthetic resveratrol on human breast epithelial cells.

  1998cited by this paper
• Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells*

  1998cited by this paper
• Regulation of protein kinase C.

  1997cited by this paper
• Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor.

  1997cited by this paper
• The Catalytic Domain of Protein Kinase C Chimeras Modulates the Affinity and Targeting of Phorbol Ester-induced Translocation*

  1997cited by this paper
• Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

  1997cited by this paper
• Mitogen-activated protein kinase pathways.

  1997cited by this paper
• Comparative studies of the mitogenic effects of epidermal growth factor and transforming growth factor‐α and the expression of various growth factors in neoplastic and non‐neoplastic prostatic cell lines

  1997cited by this paper
• The biologic effects of C225, a chimeric monoclonal antibody to the EGFR, on human prostate carcinoma.

  1996cited by this paper
• Partial Reversal of Multidrug Resistance in Human Breast Cancer Cells by an N-Myristoylated Protein Kinase C- Pseudosubstrate Peptide (*)

  1996cited by this paper
• Changing pattern of expression of the epidermal growth factor receptor and transforming growth factor alpha in the progression of prostatic neoplasms.

  1995cited by this paper
• Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor and epidermal growth factor.

  1995cited by this paper
• Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor.

  1994cited by this paper
• Protein kinase C alpha activates RAF-1 by direct phosphorylation.

  1993cited by this paper
• Protein kinase Cα activates RAF-1 by direct phosphorylation

  1993cited by this paper
• Autonomous growth of androgen-independent human prostatic carcinoma cells: role of transforming growth factor alpha.

  1991cited by this paper
• Identification of the regulatory phosphorylation sites in pp42/mitogen‐activated protein kinase (MAP kinase).

  1991cited by this paper
• Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

  1988cited by this paper

• Therapeutic Potential of Resveratrol in Cancer and Neurodegenerative Disorders: A Current Review

  2026cites this paper
• Natural Products Targeting the EGFR/HER2 Axis in Tumorigenesis: Interpretation of Molecular Mechanisms and Recent Insights Into Synergistic Strategies for Cancer Therapy

  2025cites this paper
• Machine learning in cancer prognostic and diagnostic biomarkers: A promising approach for early cancer detection

  2025cites this paper
• Resveratrol: A Review on the Biological Activity and Applications

  2024cites this paper
• Special contribution of atomic force microscopy in cell death research

  2024cites this paper
• Resveratrol as sensitizer in colorectal cancer plasticity

  2023cites this paper
• The Journey of Resveratrol from Vineyards to Clinics

  2022cites this paper
• Endocannabinoid system contributions to sex-specific adolescent neurodevelopment.

  2021cites this paper
• Quercetin and Its Nano-Scale Delivery Systems in Prostate Cancer Therapy: Paving the Way for Cancer Elimination and Reversing Chemoresistance

  2021cites this paper
• Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets

  2020cites this paper
• Mechanisms of Aging and the Preventive Effects of Resveratrol on Age-Related Diseases

  2020cites this paper
• Resveratrol inhibits the proliferation of estrogen receptor-positive breast cancer cells by suppressing EZH2 through the modulation of ERK1/2 signaling

  2019cites this paper
• Role of Oncogenic Protein Kinase C-iota in Melanoma Progression; A Study Based on Atypical Protein Kinase-C Inhibitors

  2019cites this paper
• ENDOCANNABINOID REGULATION OF ADOLESCENT DEVELOPMENT IN MALE AND FEMALE RATS

  2018cites this paper
• BASIGIN-2 MEDIATED ACTIVATION OF ERK1/2 SIGNALING IN HUMAN GLIOBLASTOMA MULTIFORME CELLS

  2017cites this paper
• Protective effects of the resveratrol analog piceid in dopaminergic SH-SY5Y cells

  2017cites this paper
• EGFR expression in patients with stage III colorectal cancer after adjuvant chemotherapy and on cancer cell function

  2017cites this paper
• Prospected epigenetic moderators from natural sources and drug of class NSAIDS as effective treatment options to prostate cancer

  2017cites this paper
• Comparative analysis of XTT assay and xCELLigence system by measuring cytotoxicity of resveratrol in human cancer cell lines

  2016cites this paper
• Polyphenol compounds and PKC signaling.

  2016cites this paper
• Targeting epidermal growth factor receptors and downstream signaling pathways in cancer by phytochemicals

  2015cites this paper
• Immunopharmacology and in fl ammation Anti-in fl ammatory effects of a triple-bond resveratrol analog : Structure and function relationship

  2015cites this paper
• Proteomic approaches for identifying new mechanisms of action and pharmacodynamic biomarkers of resveratrol in colorectal cancer

  2015cites this paper
• Dietary phytochemicals alter epigenetic events and signaling pathways for inhibition of metastasis cascade

  2014cites this paper
• Protein kinase C and cancer: what we know and what we do not

  2014cites this paper
• Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts.

  2014cites this paper
• In-situ detection of resveratrol inhibition effect on epidermal growth factor receptor of living MCF-7 cells by Atomic Force Microscopy.

  2014cites this paper
• C1 domains: structure and ligand-binding properties.

  2014cites this paper
• Managing Oxidative Stress/Targeting ROS

  2014cites this paper
• Polyphenols in prostate cancer

  2014cites this paper
• Roles of EGFR, PI3K, AKT, and mTOR in heavy metal-induced cancer.

  2013cites this paper
• Effekte von Resveratrol am Augenhintergrund

  2013cites this paper
• Zinc Protoporphyrin Upregulates Heme Oxygenase-1 in PC-3 Cells via the Stress Response Pathway

  2013cites this paper
• Resveratrol Induces Long-Lasting IL-8 Expression and Peculiar EGFR Activation/Distribution in Human Keratinocytes: Mechanisms and Implications for Skin Administration

  2013cites this paper
• Authors and affiliations

  2013cites this paper
• [Effect of resveratrol on the fundus oculi. An overview].

  2013cites this paper
• Protein Kinase C (PKC ) Splice Variants Modulate Apoptosis Pathway in 3T3L1 Cells during Adipogenesis

  2013cites this paper
• Protein Kinase C (cid:1) (PKC (cid:1) ) Splice Variants Modulate Apoptosis Pathway in 3T3L1 Cells during Adipogenesis OF PKC (cid:1) II INHIBITOR

  2013cites this paper
• PKC Activation by Resveratrol Derivatives with Unsaturated Aliphatic Chain

  2012cites this paper
• Polyphenols as Receptor Tyrosine Kinase Inhibitors and Anti-cancer Agents

  2012cites this paper
• New strategies in cancer chemoprevention by phytochemicals.

  2012cites this paper
• Inhibition of EGFR-AKT Axis Results in the Suppression of Ovarian Tumors In Vitro and in Preclinical Mouse Model

  2012cites this paper
• Modulation of arsenic-induced epidermal growth factor receptor pathway signalling by resveratrol.

  2012cites this paper
• Blocking Epidermal Growth Factor Receptor Activation by 3,3′-Diindolylmethane Suppresses Ovarian Tumor Growth In Vitro and In Vivo

  2012cites this paper
• Dietary Manipulation for Therapeutic Effect in Prostate Cancer

  2012cites this paper
• Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHβ gene expression by a SirT1-independent pathway in LβT2 gonadotrope cells.

  2011cites this paper
• GADD45α and annexin A1 are involved in the apoptosis of HL-60 induced by resveratrol.

  2011cites this paper
• SOCS‐3 antagonizes pro‐apoptotic effects of TRAIL and resveratrol in prostate cancer cells

  2011cites this paper
• Chemical modifications of resveratrol for improved protein kinase C alpha activity.

  2011cites this paper
• Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling.

  2011cites this paper
• Resveratrol and apoptosis

  2011cites this paper
• Dose-Dependency of Resveratrol in Providing Health Benefits

  2010cites this paper
• Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3.

  2010cites this paper
• Resveratrol regulates the PTEN/AKT pathway through androgen receptor-dependent and -independent mechanisms in prostate cancer cell lines

  2010cites this paper
• Multifaceted approach to resveratrol bioactivity: Focus on antioxidant action, cell signaling and safety.

  2010cites this paper
• The sphingosine kinase‐1 survival pathway is a molecular target for the tumor‐suppressive tea and wine polyphenols in prostate cancer

  2010cites this paper
• Targeting tissue oxidative damage by means of cell signaling modulators: the antioxidant concept revisited.

  2010cites this paper
• Resveratrol: Its Biologic Targets and Functional Activity

  2009cites this paper
• Métabolisme énergétique mitochondrial dans le développement de la stéatose hépatique

  2009cites this paper
• Resveratrol: One molecule, many targets

  2008cites this paper
• Resveratrol: A multitargeted agent for age-associated chronic diseases

  2008cites this paper
• Cancer Chemoprevention Through Dietary Antioxidants: Progress and Promise

  2008cites this paper
• Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives.

  2008cites this paper
• Resveratrol as an Inhibitor of Carcinogenesis

  2008cites this paper
• Biomarkers in oncology research and treatment: early detection research network: a collaborative approach.

  2008cites this paper
• Resveratrol suppresses prostate cancer progression in transgenic mice.

  2007cites this paper
• Phytochemical Regulation of UDP-Glucuronosyltransferases: Implications for Cancer Prevention

  2007cites this paper
• Expert opinion : food for thought Back to basics : how natural products can provide the basis for new therapeutics

  2007cites this paper
• Polyphenols and cancer cell growth.

  2007cites this paper
• Resveratrol Suppresses Prostate Cancer Progression in Transgenic Mice

  2007cites this paper
• The power and promise of “rewiring” the mitogen-activated protein kinase network in prostate cancer therapeutics

  2007cites this paper
• Resveratrol sensitizes androgen independent prostate cancer cells to death‐receptor mediated apoptosis through multiple mechanisms

  2007cites this paper
• Resveratrol, a polyphenolic phytoalexin attenuates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rats.

  2006cites this paper
• Regulation by phytoestrogens of migration, actin cytoskeleton, and signaling cascades relevant to cancer cell motility

  2006cites this paper
• Molecular targets of dietary agents for prevention and therapy of cancer.

  2006cites this paper
• Prostate Tumor Cells Infected with a Recombinant Influenza Virus Expressing a Truncated NS1 Protein Activate Cytolytic CD8+ Cells To Recognize Noninfected Tumor Cells

  2006cites this paper
• Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer.

  2006cites this paper
• Protein kinase CA mediates epidermal growth factor receptor transactivation in human prostate cancer cells

  2005cites this paper
• Protein kinase C-α mediates epidermal growth factor receptor transactivation in human prostate cancer cells

  2005cites this paper
• Molecular Targets of Resveratrol: Implications to Health and Disease Prevention

  2005cites this paper
• Cancer Chemoprotective Activity of Stilbenes: Resveratrol

  2005cites this paper
• Keynote review: Recent advances in biomarkers for cancer diagnosis and treatment

  2005cites this paper
• Recent advances in biomarkers for cancer diagnosis and treatment.

  2005cites this paper
• Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in carcinogenesis.

  2005cites this paper
• Reactive oxygen species in tumor progression.

  2005cites this paper
• Phytoestrogens in Cell Signaling

  2005cites this paper
• Resveratrol as an Antiproliferative Agent for Cancer

  2005cites this paper
• Resveratrol as Inhibitor of Cell Survival Signal Transduction

  2005cites this paper
• Modulation of signal transduction by tea catechins and related phytochemicals.

  2005cites this paper
• Protein kinase C-{alpha} mediates epidermal growth factor receptor transactivation in human prostate cancer cells.

  2005cites this paper
• Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.

  2004cites this paper
• Molecular diagnostics: a new frontier in cancer prevention

  2004cites this paper
• Targeting Multiple Signaling Pathways as a Strategy for Managing Prostate Cancer: Multifocal Signal Modulation Therapy

  2004cites this paper