Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Journal of Clinical Endocrinology and Metabolism

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  PMID 14764798
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes.

  2003cited by this paper
• Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets.

  2003cited by this paper
• Glucose stimulates pulsatile insulin secretion from human pancreatic islets by increasing secretory burst mass: dose-response relationships.

  2003cited by this paper
• Loss of beta-cell mass leads to a reduction of pulse mass with normal periodicity, regularity and entrainment of pulsatile insulin secretion in Göttingen minipigs

  2003cited by this paper
• Measurements of insulin secretory capacity and glucose tolerance to predict pancreatic beta-cell mass in vivo in the nicotinamide/streptozotocin Göttingen minipig, a model of moderate insulin deficiency and diabetes.

  2003cited by this paper
• Minireview: Secondary β-Cell Failure in Type 2 Diabetes-A Convergence of Glucotoxicity and Lipotoxicity.

  2002cited by this paper
• Human insulin release processes measured by intraportal sampling.

  2002cited by this paper
• Minireview: Secondary beta-cell failure in type 2 diabetes--a convergence of glucotoxicity and lipotoxicity.

  2002cited by this paper
• Pulsatile insulin secretion by human pancreatic islets.

  2002cited by this paper
• The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener.

  2002cited by this paper
• A Functional Link between Glucokinase Binding to Insulin Granules and Conformational Alterations in Response to Glucose and Insulin*

  2002cited by this paper
• 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.

  2002cited by this paper
• Glucagon-like peptide 1 increases secretory burst mass of pulsatile insulin secretion in patients with type 2 diabetes and impaired glucose tolerance.

  2001cited by this paper
• Irregular circulating insulin concentrations in type 2 diabetes mellitus: an inverse relationship between circulating free fatty acid and the disorderliness of an insulin time series in diabetic and healthy individuals.

  2001cited by this paper
• Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets.

  2001cited by this paper
• Overstimulation and beta-cell function.

  2001cited by this paper
• Impact of pulsatility on the ensemble orderliness (approximate entropy) of neurohormone secretion.

  2001cited by this paper
• Decrease in beta-cell mass leads to impaired pulsatile insulin secretion, reduced postprandial hepatic insulin clearance, and relative hyperglucagonemia in the minipig.

  2001cited by this paper
• Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes.

  2000cited by this paper
• Direct measurement of pulsatile insulin secretion from the portal vein in human subjects.

  2000cited by this paper
• A model of beta-cell mass, insulin, and glucose kinetics: pathways to diabetes.

  2000cited by this paper
• Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells

  1999cited by this paper
• Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets.

  1999cited by this paper
• Hormone pulsatility discrimination via coarse and short time sampling.

  1999cited by this paper
• Orderliness of hormone release patterns: a complementary measure to conventional pulsatile and circadian analyses.

  1998cited by this paper
• Syntaxin, but not soluble NSF attachment protein (SNAP), biosynthesis by rat pancreatic islets is regulated by glucose in parallel with proinsulin biosynthesis

  1997cited by this paper
• Disorderly and nonstationary insulin secretion in relatives of patients with NIDDM.

  1997cited by this paper
• Effects of Glucose Ingestion Versus Infusion on Pulsatile Insulin Secretion: The Incretin Effect Is Achieved by Amplification of Insulin Secretory Burst Mass

  1996cited by this paper
• Hyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humans.

  1996cited by this paper
• Diazoxide Treatment at Onset Preserves Residual Insulin Secretion in Adults with Autoimmune Diabetes

  1996cited by this paper
• Impact of sampling technique on appraisal of pulsatile insulin secretion by deconvolution and cluster analysis.

  1995cited by this paper
• Prophylaxis of genetically determined diabetes by diazoxide: a study in a rat model of naturally occurring obese diabetes.

  1995cited by this paper
• Diazoxide Causes Recovery of β-Cell Glucose Responsiveness in 90% Pancreatectomized Diabetic Rats

  1994cited by this paper
• Increased Proinsulin/Insulin Ratio in Pancreas Extracts of Hyperglycemic Rats

  1993cited by this paper
• Enzyme immunoassay for intact human insulin in serum or plasma.

  1993cited by this paper
• Sulfonylurea-binding sites and ATP-sensitive K+ channels in alpha-TC glucagonoma and beta-TC insulinoma cells.

  1993cited by this paper
• Body fat distribution and peripheral insulin sensitivity in healthy men: role of insulin pulsatility.

  1992cited by this paper
• Approximate entropy as a measure of system complexity.

  1991cited by this paper
• Relative Hypersecretion of Proinsulin in Rat Model of NIDDM

  1991cited by this paper
• Diabetes prevention in BB rats by inhibition of endogenous insulin secretion.

  1991cited by this paper
• Effects of Prolonged Pulsatile Hyperinsulinemia in Humans: Enhancement of Insulin Sensitivity

  1990cited by this paper
• Coupling of β-Cell Desensitization by Hyperglycemia to Excessive Stimulation and Circulating Insulin in Glucose-Infused Rats

  1990cited by this paper
• Insulin deficiency in non-insulin-dependent diabetes.

  1989cited by this paper
• Effects of pulsatile delivery of insulin and glucagon in humans.

  1989cited by this paper
• Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy.

  1988cited by this paper
• Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus.

  1988cited by this paper
• Severe Diabetes Induced in Subtotally Depancreatized Dogs by Sustained Hyperglycemia

  1988cited by this paper
• The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations.

  1987cited by this paper
• Efficacy of Pulsatile Versus Continuous Insulin Administration on Hepatic Glucose Production and Glucose Utilization in Type I Diabetic Humans

  1986cited by this paper
• Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus.

  1984cited by this paper
• Pulsatile Insulin Has Greater Hypoglycemic Effect Than Continuous Delivery

  1983cited by this paper
• Brief, Irregular Oscillations of Basal Plasma Insulin and Glucose Concentrations in Diabetic Man

  1981cited by this paper
• Improvement in insulin secretion in diabetes after diazoxide.

  1976cited by this paper
• A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling.

  1972cited by this paper

• Models of hyperglycaemia in diabetes mellitus and its complications.

  2026cites this paper
• Pathophysiology of Prediabetes, Diabetes, and Diabetic Remission in Cats.

  2023cites this paper
• PYY (3-36) protects against high fat feeding induced changes of pancreatic islet and intestinal hormone content and morphometry.

  2023cites this paper
• It’s What and When You Eat: An Overview of Transcriptional and Epigenetic Responses to Dietary Perturbations in Pancreatic Islets

  2022cites this paper
• SUR1 as a New Therapeutic Target for Pulmonary Arterial Hypertension.

  2022cites this paper
• Beneficial metabolic effects of recurrent periods of beta‐cell rest and stimulation using stable neuropeptide Y1 and glucagon‐like peptide‐1 receptor agonists

  2022cites this paper
• Role of Hydrogen Sulfide in the Endocrine System

  2021cites this paper
• Basal insulin ameliorates post-breakfast hyperglycemia via suppression of post-breakfast proinsulin/C-peptide ratio and fasting serum free fatty acid levels in patients with type 2 diabetes

  2020cites this paper
• Possible New Strategies for the Treatment of Congenital Hyperinsulinism

  2020cites this paper
• Development and characterisation of a peptidergic N-and C-terminally stabilised mammalian NPY1R agonist which protects against diabetes induction.

  2020cites this paper
• Beinaglutide showed significant weight‐loss benefit and effective glycaemic control for the treatment of type 2 diabetes in a real‐world setting: a 3‐month, multicentre, observational, retrospective, open‐label study

  2019cites this paper
• Effects of sequential treatment with lixisenatide, insulin glargine, or their combination on meal‐related glycaemic excursions, insulin and glucagon secretion, and gastric emptying in patients with type 2 diabetes

  2019cites this paper
• Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063

  2019cites this paper
• Characterisation and antidiabetic utility of a novel hybrid peptide, exendin‐4/gastrin/xenin‐8‐Gln

  2018cites this paper
• A novel GLP‐1/xenin hybrid peptide improves glucose homeostasis, circulating lipids and restores GIP sensitivity in high fat fed mice

  2018cites this paper
• β-Cell Failure or β-Cell Abuse?

  2018cites this paper
• Acute intravenous glucose load impairs early insulin secretion and insulin content in islet β cells in mice.

  2016cites this paper
• Islet Hypersensitivity to Glucose Is Associated With Disrupted Oscillations and Increased Impact of Proinflammatory Cytokines in Islets From Diabetes-Prone Male Mice.

  2016cites this paper
• Calbindin-D9k Ablation Disrupt Glucose/Pancreatic Insulin Homeostasis

  2016cites this paper
• Diazoxide, a KATP Channel Opener, Prevents Ischemia–Reperfusion Injury in Rodent Pancreatic Islets

  2015cites this paper
• BBT improves glucose homeostasis by ameliorating β-cell dysfunction in type 2 diabetic mice.

  2015cites this paper
• New perspectives on exploitation of incretin peptides for the treatment of diabetes and related disorders.

  2015cites this paper
• Sequential induction of beta cell rest and stimulation using stable GIP inhibitor and GLP-1 mimetic peptides improves metabolic control in C57BL/KsJ db/db mice

  2015cites this paper
• Hyperglycaemia is associated with impaired pulsatile insulin secretion: effect of basal insulin therapy

  2013cites this paper
• Nov/Ccn3, a Novel Transcriptional Target of FoxO1, Impairs Pancreatic β-Cell Function

  2013cites this paper
• Some cannabinoid receptor ligands and their distomers are direct-acting openers of SUR1 K ATP channels

  2012cites this paper
• Ghrelin Inhibits Insulin Release by Regulating the Expression of Inwardly Rectifying Potassium Channel 6.2 in Islets

  2012cites this paper
• The glucokinase activator AZD6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food.

  2012cites this paper
• The molecular mechanisms of pancreatic β-cell glucotoxicity: recent findings and future research directions.

  2012cites this paper
• Over-nutrition, obesity and insulin resistance in the development of β-cell dysfunction.

  2012cites this paper
• Chronic Reduction of Fasting Glycemia With Insulin Glargine Improves First- and Second-Phase Insulin Secretion in Patients With Type 2 Diabetes

  2011cites this paper
• Beta-cell selective K(ATP)-channel activation protects beta-cells and human islets from human islet amyloid polypeptide induced toxicity.

  2010cites this paper
• Effects of cyclooxygenase-2 inhibitor and adenosine triphosphate-sensitive potassium channel opener in syngeneic mouse islet transplantation.

  2010cites this paper
• Preservation of the donor pancreas for whole pancreas and islet transplantation

  2010cites this paper
• Inhibition of human insulin gene transcription by peroxisome proliferator‐activated receptor γ and thiazolidinedione oral antidiabetic drugs

  2009cites this paper
• A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic beta-cells.

  2009cites this paper
• Genetic and biochemical pathways of β‐cell failure in type 2 diabetes

  2009cites this paper
• Goals of Treatment for Type 2 Diabetes

  2009cites this paper
• Effects of beta‐cell rest on beta‐cell function: a review of clinical and preclinical data

  2008cites this paper
• Potential benefits of early addition of rosiglitazone in combination with glimepiride in the treatment of type 2 diabetes

  2008cites this paper
• Beta cell mass in diabetes: a realistic therapeutic target?

  2008cites this paper
• Possible role of an ischemic preconditioning-like response mechanism in K(ATP) channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function.

  2008cites this paper
• The role of FoxO in the regulation of metabolism

  2008cites this paper
• Islet Inflammation in Type 2 Diabetes

  2008cites this paper
• Predicting the success of pancreatic islet isolation : a study of pancreatic preservation and islet cell apoptosis

  2008cites this paper
• Hyperpolarization-activated cyclic nucleotide-gated channels in pancreatic beta-cells.

  2007cites this paper
• Metabolic Diapause in Pancreatic β-Cells Expressing a Gain-of-function Mutant of the Forkhead Protein Foxo1*

  2007cites this paper
• The Actions of a Novel Potent Islet β-Cell–Specific ATP-Sensitive K+ Channel Opener Can Be Modulated by Syntaxin-1A Acting on Sulfonylurea Receptor 1

  2007cites this paper
• Human Insulin Vesicle Dynamics During Pulsatile Secretion

  2007cites this paper
• Evaluation of beta-cell mass and function in the Göttingen minipig.

  2007cites this paper
• Oxidative Stress and Inflammatory Mechanisms in Obesity, Diabetes, and the Metabolic Syndrome

  2007cites this paper
• Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives.

  2006cites this paper
• Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomy.

  2006cites this paper
• Mechanisms of Impaired Fasting Glucose and Glucose Intolerance Induced by a ∼50% Pancreatectomy

  2006cites this paper
• New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.

  2006cites this paper
• Three-dimensional quantitative structure-activity relationships of ATP-sensitive potassium (KATP) channel openers belonging to the 3-alkylamino-4H-1,2,4-benzo- and 3-alkylamino-4H-1,2,4-pyridothiadiazine 1,1-dioxide families.

  2006cites this paper
• The mass, but not the frequency, of insulin secretory bursts in isolated human islets is entrained by oscillatory glucose exposure.

  2006cites this paper
• The Potential for Stem Cell Therapy in Diabetes

  2006cites this paper
• Relationship Between β-Cell Mass and Fasting Blood Glucose Concentration in Humans

  2006cites this paper
• Mechanisms of β-Cell Death in Type 2 Diabetes

  2005cites this paper
• Pharmacological interventions that directly stimulate or modulate insulin secretion from pancreatic β‐cell: implications for the treatment of type 2 diabetes

  2005cites this paper
• Rosiglitazone/metformin fixed-dose combination compared with uptitrated metformin alone in type 2 diabetes mellitus: a 24-week, multicenter, randomized, double-blind, parallel-group study.

  2005cites this paper
• The Effects of NN414, a SUR1/Kir6.2 Selective Potassium Channel Opener, in Healthy Male Subjects

  2005cites this paper
• Mechanisms of beta-cell death in type 2 diabetes.

  2005cites this paper
• Inhibition of insulin secretion as a new drug target in the treatment of metabolic disorders.

  2004cites this paper
• Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

  2004cites this paper
• 2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels.

  2004cites this paper
• Islet regeneration needed for overcoming autoimmune destruction – considerations on the pathogenesis of type 1 diabetes

  2004cites this paper
• ffects of Cyclooxygenase-2 Inhibitor and Adenosine riphosphate – Sensitive Potassium Channel Opener in Syngeneic ouse Islet Transplantation

  year unknowncites this paper