Is stagnant cerebrospinal fluid involved in the pathophysiology of normal tension glaucoma.

Current concepts of the pathophysiology of normal tension glaucoma (NTG) include intraocular pressure, vascular dysregulation and the concept of a translaminar pressure gradient. Studies on NTG performed with cisternography demonstrated an impaired cerebrospinal fluid (CSF) dynamics in the subarachnoid space of the optic nerve sheath, most pronounced behind the lamina cribrosa. Stagnant CSF might be another risk factor for NTG.

• Publication year

  2020

• Venue

  Progress in Brain Research

• Publication date

  2020-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/bs.pbr.2020.06.004PMID 32958213
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cerebrospinal fluid and optic nerve sheath compartment syndrome: A common pathophysiological mechanism in five different cases?

  2020cited by this paper
• Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

  2020cited by this paper
• Disruption of brain network organization in primary open angle glaucoma

  2019cited by this paper
• A perfusion bioreactor-based 3D model of the subarachnoid space based on a meningeal tissue construct

  2019cited by this paper
• Current concepts of cerebrospinal fluid dynamics and the translaminar cribrosa pressure gradient: a paradigm of optic disc disease.

  2019cited by this paper
• Flow dynamics of cerebrospinal fluid between the intracranial cavity and the subarachnoid space of the optic nerve measured with a diffusion magnetic resonance imaging sequence in patients with normal tension glaucoma

  2018cited by this paper
• Diffuse brain damage in normal tension glaucoma

  2018cited by this paper
• Glaucoma may be a non-memory manifestation of Alzheimer's disease in older people

  2017cited by this paper
• Cell–Cell Interaction Proteins (Gap Junctions, Tight Junctions, and Desmosomes) and Water Transporter Aquaporin 4 in Meningothelial Cells of the Human Optic Nerve

  2017cited by this paper
• The Optic Canal: A Bottleneck for Cerebrospinal Fluid Dynamics in Normal-Tension Glaucoma?

  2017cited by this paper
• Translamina Cribrosa Pressure Difference as Potential Element in the Pathogenesis of Glaucomatous Optic Neuropathy

  2016cited by this paper
• Unilateral loss of spontaneous venous pulsations in an astronaut.

  2015cited by this paper
• Glaucoma considered as an imbalance between production and clearance of neurotoxins.

  2014cited by this paper
• A new look at cerebrospinal fluid circulation

  2014cited by this paper
• Population-based glaucoma prevalence studies in Asians.

  2014cited by this paper
• Compartmentalized Cerebrospinal Fluid

  2014cited by this paper
• Quantitative proteomics comparison of arachnoid cyst fluid and cerebrospinal fluid collected perioperatively from arachnoid cyst patients

  2013cited by this paper
• Deciphering the Contribution of Human Meningothelial Cells to the Inflammatory and Antimicrobial Response at the Meninges

  2013cited by this paper
• Prostaglandin D2 synthase: Apoptotic factor in alzheimer plasma, inducer of reactive oxygen species, inflammatory cytokines and dialysis dementia.

  2013cited by this paper
• Meningothelial cells as part of the central nervous system host defence

  2013cited by this paper
• Meningothelial cells participate in immunological processes in the cerebrospinal fluid.

  2012cited by this paper
• Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight.

  2011cited by this paper
• Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma

  2011cited by this paper
• Optic nerve sheath diameter in normal-tension glaucoma patients

  2011cited by this paper
• Anatomy and physiology of cerebrospinal fluid.

  2011cited by this paper
• Meningothelial Cells React to Elevated Pressure and Oxidative Stress

  2011cited by this paper
• Cerebrospinal fluid segregation optic neuropathy: an experimental model and a hypothesis

  2010cited by this paper
• L-PGDS (Betatrace Protein) Inhibits Astrocyte Proliferation and Mitochondrial ATP Production in Vitro

  2009cited by this paper
• Optic Nerve Compartment Syndrome in a Patient with Optic Nerve Sheath Meningioma

  2007cited by this paper
• Lipocalin-type prostaglandin D synthase/β-trace is a major amyloid β-chaperone in human cerebrospinal fluid

  2007cited by this paper
• Glaucoma as a neurodegenerative disease

  2007cited by this paper
• Morphological Changes of the Retrobulbar Optic Nerve and Its Meningeal Sheaths in Glaucoma

  2006cited by this paper
• The optic nerve: a new window into cerebrospinal fluid composition?

  2006cited by this paper
• A sick eye in a sick body? Systemic findings in patients with primary open-angle glaucoma.

  2006cited by this paper
• Cerebrospinal Fluid Research BioMed Central Review Integration of the subarachnoid space and lymphatics: Is it time to

  2005cited by this paper
• Evidence of connections between cerebrospinal fluid and nasal lymphatic vessels in humans, non-human primates and other mammalian species

  2004cited by this paper
• Architecture of arachnoid trabeculae, pillars, and septa in the subarachnoid space of the human optic nerve: anatomy and clinical considerations

  2003cited by this paper
• Alzheimer's disease, normal-pressure hydrocephalus, and senescent changes in CSF circulatory physiology: a hypothesis.

  2003cited by this paper
• Lymphatic cerebrospinal fluid absorption pathways in neonatal sheep revealed by subarachnoid injection of Microfil

  2003cited by this paper
• Elevated L-PGDS activity contributes to PMA-induced apoptosis concomitant with downregulation of PI3-K.

  2003cited by this paper
• The Importance of Lymphatics in Cerebrospinal Fluid Transport

  2003cited by this paper
• The impact of ocular blood flow in glaucoma.

  2002cited by this paper
• The distribution of mitochondrial activity in relation to optic nerve structure.

  2002cited by this paper
• Pressure gradients within the central nervous system.

  1999cited by this paper
• Histochemical localisation of mitochondrial enzyme activity in human optic nerve and retina

  1999cited by this paper
• Lymphatic capillaries in the meninges of the human optic nerve.

  1999cited by this paper
• Collaborative normal-tension glaucoma study.

  1999cited by this paper
• Interhemispheric pressure gradients in severe head trauma in humans.

  1998cited by this paper
• Raised intracranial pressure increases CSF drainage through arachnoid villi and extracranial lymphatics.

  1998cited by this paper
• The global impact of glaucoma.

  1994cited by this paper
• Prevalence of glaucoma. The Beaver Dam Eye Study.

  1992cited by this paper
• Modified optic nerve decompression in patients with functioning lumboperitoneal shunts and progressive visual loss.

  1991cited by this paper
• Notes on the driving forces of the CSF circulation with special emphasis on the piston action of the brain

  1991cited by this paper
• Optic nerve sheath meningoceles. Clinical and radiographic features in 13 cases with a review of the literature.

  1990cited by this paper
• Bilateral optic disc colobomas with orbital cysts and hypoplastic optic nerves and chiasm.

  1989cited by this paper
• Physiology and Pathophysiology of the Cerebrospinal Fluid

  1987cited by this paper
• Optic disc edema in raised intracranial pressure. II. Early detection with fluorescein fundus angiography and stereoscopic color photography.

  1977cited by this paper
• Optic disc edema in raised intracranial pressure. I. Evolution and resolution.

  1977cited by this paper
• Hydrocephalus and the Cerebrospinal Fluid

  1972cited by this paper
• BETA‐TRACE PROTEIN CONCENTRATION IN CSF IN NEUROLOGICAL DISORDERS

  1972cited by this paper
• Cyst of Dural Sheath of Optic Nerve

  year unknowncited by this paper

• Eye Movements and the Intraorbital Subarachnoid Space: Potential Contribution of Altered Cerebrospinal Fluid Pumping in Optic Neuropathies

  2025cites this paper
• A Live Cell Imaging‐Compatible Bioreactor for the Interrogation of Cellular Responses to Modulated Flow Conditions

  2025cites this paper
• Normal-Tension Glaucoma and Potential Clinical Links to Alzheimer’s Disease

  2024cites this paper
• Intraocular pressure and optical coherence tomography concerning visual field outcomes in “green” patients: An observational study

  2024cites this paper
• Large-scale morphometry of the subarachnoid space of the optic nerve

  2023cites this paper
• Empty-Sella-Syndrom und/oder Normaldruckglaukom?

  2022cites this paper