Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of antibiotics (Tokyo. 1968)

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/ja.2010.135PMID 21081950PMCID PMC3030646
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1992cited by this paper
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  1990cited by this paper
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  1987cited by this paper
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  1984cited by this paper
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  1983cited by this paper
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  1978cited by this paper
• [Metabolic products of microorganisms. 105. Arenacemycin E, D and C].

  1972cited by this paper
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  1970cited by this paper
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  1964cited by this paper
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  1957cited by this paper
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  1956cited by this paper
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  1956cited by this paper
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