Antipsychotics with inverse agonist activity at the dopamine D3 receptor

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of neural transmission

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF01271201PMID 9013403
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inverse Agonist Activity of 3-Adrenergic Antagonists

  2005cited by this paper
• Functional models for the dopamine D3 receptor.

  1996cited by this paper
• Inverse agonism: pharmacological curiosity or potential therapeutic strategy?

  1995cited by this paper
• The two-state model of receptor activation.

  1995cited by this paper
• Phenotypical characterization of neurons expressing the dopamine D3 receptor in the rat brain.

  1995cited by this paper
• Novel dopamine receptors half a decade later.

  1995cited by this paper
• The preferential dopamine D3 receptor ligand, (+)-UH232, is a partial agonist.

  1995cited by this paper
• Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor

  1995cited by this paper
• A functional test identifies dopamine agonists selective for D3 versus D2 receptors.

  1995cited by this paper
• Nafadotride, a potent preferential dopamine D3 receptor antagonist, activates locomotion in rodents.

  1995cited by this paper
• Mesolimbic dopamine D3 receptors: elevation in schizophrenics

  1994cited by this paper
• Pharmacological and functional characterization of D2, D3 and D4 dopamine receptors in fibroblast and dopaminergic cell lines.

  1994cited by this paper
• Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

  1994cited by this paper
• Behavioral and neurochemical data suggest functional differences between dopamine D2 and D3 receptors.

  1994cited by this paper
• Inverse agonist activity of beta-adrenergic antagonists.

  1994cited by this paper
• Characterization of the human dopamine D3 receptor expressed in transfected cell lines.

  1994cited by this paper
• Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors.

  1994cited by this paper
• Germline mutations in the thyrotropin receptor gene cause non–autoimmune autosomal dominant hyperthyroidism

  1994cited by this paper
• High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype.

  1994influential reference
• Functional coupling of the human dopamine D3 receptor in a transfected NG 108-15 neuroblastoma-glioma hybrid cell line.

  1994cited by this paper
• Expression and pharmacological characterization of the human D3 dopamine receptor.

  1994cited by this paper
• Regulation of basal adenylate cyclase activity in neuroblastoma x glioma hybrid, NG108-15, cells transfected to express the human beta 2 adrenoceptor: evidence for empty receptor stimulation of the adenylate cyclase cascade.

  1994cited by this paper
• Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor.

  1994cited by this paper
• Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands.

  1994cited by this paper
• A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

  1993cited by this paper
• Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function.

  1993cited by this paper
• Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

  1993cited by this paper
• Constitutively active mutants of the alpha 2-adrenergic receptor.

  1993cited by this paper
• A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model.

  1993cited by this paper
• Mutations that alter the third cytoplasmic loop of the a-factor receptor lead to a constitutive and hypersensitive phenotype.

  1993cited by this paper
• Pharmacology of human dopamine D3 receptor expressed in a mammalian cell line: comparison with D2 receptor.

  1992cited by this paper
• Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand.

  1992influential reference
• Constitutively active mutants of rhodopsin.

  1992cited by this paper
• Stable expression of human D3 dopamine receptors in GH4C1 pituitary cells

  1992cited by this paper
• Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.

  1992cited by this paper
• Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.

  1990cited by this paper
• Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics

  1990cited by this paper
• Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.

  1989cited by this paper
• A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

  1980cited by this paper

• Structure-Function Activity Relationships of Cariprazine Analogues with Distinct G Protein versus β-Arrestin Activities at the Dopamine D3 Receptor.

  2025cites this paper
• Discovery, Characterization, and Optimization of a Novel Positive Allosteric Modulator-Antagonist of the D3 Dopamine Receptor.

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• ESG-1–60 and ESG-1–61: Novel dopamine D3 receptor-preferring partial agonists/antagonists that inhibit cocaine taking and seeking in rodents

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• Synthesis, in silico, and in vitro studies of novel dopamine D2 and D3 receptor ligands

  2021cites this paper
• Role of dopamine D2-like receptors and their modulation by adenosine receptor stimulation in the reinstatement of methamphetamine seeking

  2018cites this paper
• Discovery of CNS-Like D3R-Selective Antagonists Using 3D Pharmacophore Guided Virtual Screening

  2018cites this paper
• Molecular dynamics simulation of d-Benzedrine transmitting through molecular channels within D3R

  2017cites this paper
• Structural Basis and Mechanism of Chiral Benzedrine Molecules Interacting With Third Dopamine Receptor.

  2016cites this paper
• The frontal cortex as a network hub controlling mood and cognition: Probing its neurochemical substrates for improved therapy of psychiatric and neurological disorders

  2016cites this paper
• Regulation of neutrophil phagocytosis of Escherichia coli by antipsychotic drugs.

  2014cites this paper
• Constitutive activities and inverse agonism in dopamine receptors.

  2014influential citation
• Effect of dopamine and serotonin receptor antagonists on fencamfamine-induced abolition of latent inhibition.

  2013cites this paper
• Inverse agonism and its therapeutic significance

  2011cites this paper
• Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

  2010cites this paper
• Chapter 3 – Receptors

  2009cites this paper
• Antipsychotic drug action: antagonism, inverse agonism or partial agonism.

  2008cites this paper
• A Review of the Discovery, Pharmacological Characterization, and Behavioral Effects of the Dopamine D2‐Like Receptor Antagonist Eticlopride

  2008cites this paper
• Dopamine Receptors

  2008cites this paper
• Review: Amino acid domains involved in constitutive activation of G-protein-coupled receptors

  2007cites this paper
• Dopamine D2 receptor-mediated G protein activation assessed by agonist-stimulated [35S]guanosine 5'-O-(gamma-thiotriphosphate) binding in rat striatal membranes.

  2006cites this paper
• Intrinsic Efficacy of Antipsychotics at Human D2, D3, and D4 Dopamine Receptors: Identification of the Clozapine Metabolite N-Desmethylclozapine as a D2/D3 Partial Agonist

  2005cites this paper
• Inverse agonist properties of atypical antipsychotic drugs.

  2004cites this paper
• Efficacy as a vector: the relative prevalence and paucity of inverse agonism.

  2004cites this paper
• Modulation of the discriminative stimulus effects of mu opioid agonists in rats: I. Effects of dopamine D2/3 antagonists

  2004cites this paper
• Therapeutic implications of constitutive activity of receptors: the example of the histamine H3 receptor.

  2003cites this paper
• Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors

  2002cites this paper
• Methods to determine the constitutive activity of histamine H2 receptors.

  2002cites this paper
• Differential effects of high-dose amisulpride versus flupentixol on latent dimensions of depressive and negative symptomatology in acute schizophrenia: an evaluation using confirmatory factor analysis

  2002cites this paper
• Histamine H3‐receptor‐mediated [35S]GTPγ[S] binding: evidence for constitutive activity of the recombinant and native rat and human H3 receptors

  2002cites this paper
• Constitutive activity at serotonin 5-HT(1D) receptors: detection by homologous GTPgammaS versus [(35)S]-GTPgammaS binding isotherms.

  2001cites this paper
• Biphasic modulation of NMDA‐induced responses in pyramidal cells of the medial prefrontal cortex by Y‐931, a potential atypical antipsychotic drug

  2001cites this paper
• Antipsychotic drugs: importance of dopamine receptors for mechanisms of therapeutic actions and side effects.

  2001cites this paper
• Basal signaling activity of human dopamine D2L receptor demonstrated with an ecdysone-inducible mammalian expression system.

  2000cites this paper
• Reciprocal autoreceptor and heteroreceptor control of serotonergic, dopaminergic and noradrenergic transmission in the frontal cortex: relevance to the actions of antidepressant agents

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• Estrogen priming modulates autoreceptor-mediated potentiation of dopamine uptake.

  2000cites this paper
• G-protein sensitivity of ligand binding to human dopamine D(2) and D(3) receptors expressed in Escherichia coli: clues for a constrained D(3) receptor structure.

  2000cites this paper
• Possible implications of the dopamine D(3) receptor in schizophrenia and in antipsychotic drug actions.

  2000cites this paper
• Inverse agonism at G protein‐coupled receptors: (patho)physiological relevance and implications for drug discovery

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  2000cites this paper
• Agonism and inverse agonism at dopamine D2-like receptors.

  1999cites this paper
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• Effects of reciprocal chimeras between the C‐terminal portion of third intracellular loops of the human dopamine D2 and D3 receptors

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• Constitutive Activity and Structural Instability of the Wild‐Type Human H2 Receptor

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• Direct dopamine D2‐receptor‐mediated modulation of arachidonic acid release in transfected CHO cells without the concomitant administration of a Ca2+‐mobilizing agent

  1998cites this paper
• Agonist and inverse agonist activity at the dopamine D3 receptor measured by guanosine 5'--gamma-thio-triphosphate--35S- binding.

  1998cites this paper
• Modulation of forskolin‐mediated adenylyl cyclase activation by constitutively active Gs‐coupled receptors

  1997cites this paper
• Selective Expression of Dopamine D3 Receptor mRNA in Proliferative Zones during Embryonic Development of the Rat Brain

  1997cites this paper
• Reciprocal Autoreceptor and Heteroreceptor Control of Serotonergic, Dopaminergic and Noradrenergic on Behalf Of: British Association for Psychopharmacology

  year unknowncites this paper