Selective, potent PPARgamma agonists with cyclopentenone core structure.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Bioorganic & Medicinal Chemistry Letters

• Publication date

  2009-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bmcl.2009.02.072PMID 19275963
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005cited by this paper
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  2005cited by this paper
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  2005cited by this paper
• Theoretical study of the electrocyclic ring closure of hydroxypentadienyl cations.

  2004cited by this paper
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  2004cited by this paper
• Halogen bonds in biological molecules.

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1990cited by this paper
• Preadipocyte differentiation in vitro: Identification of a highly active adipogenic agent

  1988cited by this paper
• Stereospecific palladium-catalyzed coupling reactions of vinyl iodides with acetylenic tin reagents

  1987cited by this paper
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  1986cited by this paper
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  1985cited by this paper
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  1981cited by this paper
• A rapid, simple, and mild procedure for alkylation of phenols, alcohols, amides and acids

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  1976cited by this paper
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  1972cited by this paper
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  1954cited by this paper

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