Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Blood

• Publication date

  1999-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V93.9.2780.409A47_2780_2790PMID 10216071
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Development of acute lymphoblastic leukemia and myeloproliferative disorder in transgenic mice expressing p210bcr/abl: a novel transgenic model for human Ph1-positive leukemias.

  1998cited by this paper
• The AD1 and AD2 Transactivation Domains of E2A Are Essential for the Antiapoptotic Activity of the Chimeric Oncoprotein E2A-HLF

  1998cited by this paper
• A PMLRARα transgene initiates murine acute promyelocytic leukemia

  1997cited by this paper
• Acute leukemia with promyelocytic features in PML/RARα transgenic mice

  1997cited by this paper
• The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors.

  1997cited by this paper
• Acute leukemia with promyelocytic features in PML/RARalpha transgenic mice.

  1997cited by this paper
• A PMLRARalpha transgene initiates murine acute promyelocytic leukemia.

  1997cited by this paper
• Cell transformation mediated by homodimeric E2A-HLF transcription factors

  1997cited by this paper
• E2A-HLF chimeric transcription factors in pro-B cell acute lymphoblastic leukemia.

  1997cited by this paper
• E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas

  1997cited by this paper
• Protein dimerization between Lmo2 (Rbtn2) and Tal1 alters thymocyte development and potentiates T cell tumorigenesis in transgenic mice.

  1996cited by this paper
• Reversal of apoptosis by the leukaemia-associated E2A–HLF chimaeric transcription factor

  1996cited by this paper
• DNA-binding by oncoprotein E2a-Pbx1 is important for blocking differentiation but dispensable for fibroblast transformation.

  1996cited by this paper
• E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF

  1995cited by this paper
• Expression of p210bcr/abl by metallothionein promoter induced T-cell leukemia in transgenic mice.

  1995cited by this paper
• Simultaneous determination of cell surface antigens and apoptosis.

  1994cited by this paper
• Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation

  1994cited by this paper
• Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable

  1994cited by this paper
• DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein

  1994cited by this paper
• The helix-loop-helix gene E2A is required for B cell formation.

  1994cited by this paper
• Simultaneous determination of cell surface antigens and apoptosis.

  1994cited by this paper
• E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements.

  1994cited by this paper
• Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells.

  1994cited by this paper
• Chromosomal translocations in human cancer

  1994cited by this paper
• bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death.

  1993cited by this paper
• Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice.

  1993cited by this paper
• Localization of E2A mRNA expression in developing and adult rat tissues.

  1993cited by this paper
• Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

  1992cited by this paper
• Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.

  1992cited by this paper
• Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia.

  1992cited by this paper
• The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis.

  1991cited by this paper
• Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins

  1991cited by this paper
• Oncogenic conversion of transcription factors by chromosomal translocations.

  1991cited by this paper
• Transgenic models of tumor development.

  1991cited by this paper
• Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow

  1991cited by this paper
• IgH enhancer deregulated expression of L‐myc: abnormal T lymphocyte development and T cell lymphomagenesis.

  1990cited by this paper
• Acute leukaemia in bcr/abl transgenic mice

  1990cited by this paper
• Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.

  1990cited by this paper
• A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL.

  1990cited by this paper
• Strain dependency of B and T lymphoma development in immunoglobulin heavy chain enhancer (E mu)-myc transgenic mice

  1989cited by this paper
• A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.

  1989cited by this paper
• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.

  1987cited by this paper
• The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

  1985cited by this paper
• Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation.

  1984cited by this paper

• Transcription factor VBP specifically regulates granulocyte apoptosis during the immune response in oysters.

  2025cites this paper
• Evaluation of current mouse in vivo models and advanced in vitro models for leukaemia research.

  2025cites this paper
• Resistance Mechanisms in Pediatric B-Cell Acute Lymphoblastic Leukemia

  2022cites this paper
• NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia.

  2018cites this paper
• The Role of Hepatic Leukemia Factor in Hematopoiesis

  2018influential citation
• Thyrotroph embryonic factor is downregulated in bladder cancer and suppresses proliferation and tumorigenesis via the AKT/FOXOs signalling pathway

  2018cites this paper
• Conditional Expression of E2A-HLF Induces B-Cell Precursor Death and Myeloproliferative-Like Disease in Knock-In Mice

  2015influential citation
• Time-dependent variation of pathways and networks in a 24-hour window after cerebral ischemia-reperfusion injury

  2015cites this paper
• Genomics and drug profiling of fatal TCF3-HLF-positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options

  2015cites this paper
• Genetically engineered mouse models of human B-cell precursor leukemias

  2014cites this paper
• Murine Models of Acute Leukemia: Important Tools in Current Pediatric Leukemia Research

  2014influential citation
• Hepatic leukemia factor promotes resistance to cell death: implications for therapeutics and chronotherapy.

  2013cites this paper
• Gene Expression Profiling Combined with Bioinformatics Analysis Identify Biomarkers for Parkinson Disease

  2012cites this paper
• LMO2 expression reflects the different stages of blast maturation and genetic features in B-cell acute lymphoblastic leukemia and predicts clinical outcome

  2011cites this paper
• Regulation of RNA polymerase III transcription by the ID1, ID2, ID3 and E47 proteins

  2010cites this paper
• Mécanisme de leucémogénèse par les oncogènes SCL et LMO1

  2010cites this paper
• Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia

  2010cites this paper
• Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19).

  2010cites this paper
• E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3; p13.3) in acute leukemia

  2008cites this paper
• Expression of Helix-Loop-Helix Proteins in Classical Hodgkin Lymphoma: A Possible Explanation for a Characteristic Immunophenotype

  2008cites this paper
• Genetic Modeling of Human Blood Cancers in Mice

  2008cites this paper
• FINAL APPROVAL OF DISSERTATION Doctor of Philosophy in Biomedical Sciences

  2008cites this paper
• Mouse Models of Human Blood Cancers

  2008cites this paper
• RANBP17, A Novel Non-bHLH Binding Partner of bHLH Transcription Factor E12

  2008cites this paper
• Constitutive activation of Flt3 and STAT5A enhances self-renewal and alters differentiation of hematopoietic stem cells.

  2007cites this paper
• Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19

  2007cites this paper
• The incidence of T-cell receptor gene rearrangements in childhood B-lineage acute lymphoblastic leukemia is related to immunophenotype and fusion oncogene expression.

  2006cites this paper
• Intrinsic inhibition of transcription factor E2A by HLH proteins ABF-1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma

  2006cites this paper
• Parallel Analysis of Gene Expression: Bone Cells as a Model System

  2005cites this paper
• TEF, an antiapoptotic bZIP transcription factor related to the oncogenic E2A-HLF chimera, inhibits cell growth by down-regulating expression of the common beta chain of cytokine receptors.

  2005cites this paper
• Hierarchical and ontogenic positions serve to define the molecular basis of human hematopoietic stem cell behavior.

  2005cites this paper
• The Identification of Cooperating Mutations in TAL1-Mediated Leukemia in the Mouse: A Dissertation

  2005cites this paper
• Cytogenetic and molecular abnormalities in lymphoid malignancies

  2004cites this paper
• Black tea protects immunocytes from tumor-induced apoptosis by changing Bcl-2/Bax ratio.

  2004cites this paper
• The 5'-upstream region of human programmed cell death 5 gene contains a highly active TATA-less promoter that is up-regulated by etoposide.

  2004cites this paper
• Mechanisms of TAL1 Induced Leukemia in Mice: A Dissertation

  2004cites this paper
• Gradient of E2A Activity in B-Cell Development

  2002influential citation
• A BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS IN HUMAN LEUKEMIA

  2002cites this paper
• Transformation of Bone Marrow B-Cell Progenitors by E2A-HLF Requires Coexpression of BCL-2

  2002cites this paper
• Identification of the E2A Gene Products as Regulatory Targets of the G1 Cyclin-dependent Kinases*

  2001cites this paper
• E2A-HLF usurps control of evolutionarily conserved survival pathways

  2001cites this paper
• The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukemia varies with age and genotype

  2000cites this paper
• The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukemia varies with age and genotype.

  2000cites this paper
• Fates of human B-cell precursors.

  2000cites this paper
• Role for Homodimerization in Growth Deregulation by E2a Fusion Proteins

  2000cites this paper
• Characterization of the mUBC9-binding Sites Required for E2A Protein Degradation*

  1999cites this paper