Phase I study of TLK286 (glutathione S-transferase P1-1 activated glutathione analogue) in advanced refractory solid malignancies.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Clinical Cancer Research

• Publication date

  2003-05-01

• Fields of study

  Medicine

• Identifiers
  PMID 12738715
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A proposed mechanism of resistance to cyclophosphamide and phosphoramide mustard in a Yoshida cell line in vitro

  2004cited by this paper
• Comparative pharmacokinetics of antitumor Vinca alkaloids: intravenous bolus injections of navelbine and related alkaloids to cancer patients and rats

  2004cited by this paper
• Glutathione S-Transferase π Immunostaining of Cisplatin-Resistant Ovarian Cancer Cells in Ascites

  1998cited by this paper
• Tumor efficacy and bone marrow-sparing properties of TER286, a cytotoxin activated by glutathione S-transferase.

  1998cited by this paper
• Resistance factors in colon cancer tissue and the adjacent normal colon tissue: glutathione S-transferases alpha and pi, glutathione and aldehyde dehydrogenase.

  1998cited by this paper
• Correlation between the immunohistochemical and mRNA expression of glutathione S-transferase-π and cisplatin plus etoposide chemotherapy response in patients with untreated primary non-small cell lung cancer

  1998cited by this paper
• Correlation between the immunohistochemical and mRNA expression of glutathione S-transferase-pi and cisplatin plus etoposide chemotherapy response in patients with untreated primary non-small cell lung cancer.

  1997cited by this paper
• Activity of TER286 against human tumor colony-forming units.

  1997cited by this paper
• Prognostic significance of glutathione S-transferase pi expression and subcellular localization in human gliomas.

  1997cited by this paper
• Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S-Transferase Pi Gene Variants

  1997cited by this paper
• Prognostic significance of the expressions of metallothionein, glutathione-S-transferase-pi, and P-glycoprotein in curatively resected gastric cancer.

  1997cited by this paper
• Molecular Cloning, Characterization, and Expression in Escherichia coli of Full-length cDNAs of Three Human Glutathione S -Transferase Pi Gene Variants EVIDENCE FOR DIFFERENTIAL CATALYTIC ACTIVITY OF THE ENCODED PROTEINS*

  1997cited by this paper
• [Correlation between an enzyme (glutathione S-transferase-pi) and effects of chemotherapy (cisplatin + etoposide)].

  1996cited by this paper
• Drug resistance mechanisms in chronic lymphocytic leukemia.

  1996cited by this paper
• Design, synthesis, and evaluation of latent alkylating agents activated by glutathione S-transferase.

  1996influential reference
• Expression of resistance-related proteins in tumoral and peritumoral tissues of patients with lung cancer.

  1996cited by this paper
• Glutathione S-transferase pi in colorectal tumors is predictive for overall survival.

  1995cited by this paper
• Glutathione-S-transferase activates novel alkylating agents.

  1994influential reference
• Expression of glutathione s‐transferasepi and sensitivity of human gastric cancer cells to cisplatin

  1994cited by this paper
• Preclinical and Clinical Modulation of Anticancer Drugs

  1993cited by this paper
• Glutathione S-transferase expression in benign and malignant ovarian tumours.

  1993cited by this paper
• Expression of glutathione-S-transferase-pi in human tumours.

  1992cited by this paper
• Expression of glutathione transferase pi as a predictor for treatment results at different stages of acute nonlymphoblastic leukemia.

  1992cited by this paper
• Expression of glutathione-S-transferase-π in human tumours

  1992cited by this paper
• Drug-metabolizing enzyme expression in human normal, peritumoral and tumoral colorectal tissue samples.

  1991cited by this paper
• Enhanced expression of glutathione S-transferases in colorectal carcinoma compared to non-neoplastic mucosa.

  1991cited by this paper
• Characterization of glutathione S-transferase expression in lymphocytes from chronic lymphocytic leukemia patients.

  1990cited by this paper
• Glutathione S-transferases: role in alkylating agent resistance and possible target for modulation chemotherapy--a review.

  1990cited by this paper
• A formula to estimate the approximate surface area if height and weight be known

  1989influential reference
• Glutathione and glutathione-dependent enzymes in ovarian adenocarcinoma cell lines derived from a patient before and after the onset of drug resistance: intrinsic differences and cell cycle effects.

  1988cited by this paper
• Reduced levels of drug-induced DNA cross-linking in nitrogen mustard-resistant Chinese hamster ovary cells expressing elevated glutathione S-transferase activity.

  1987cited by this paper
• Characterization of a human squamous carcinoma cell line resistant to cis-diamminedichloroplatinum(II).

  1987cited by this paper
• Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

  1986cited by this paper

• The role of GSTπ isoform in the cells signalling and anticancer therapy.

  2020cites this paper
• Glutathione, an antioxidant tripeptide: Dual roles in Carcinogenesis and Chemoprevention.

  2019cites this paper
• Glutathione system in animal model of solid tumors: From regulation to therapeutic target.

  2018cites this paper
• 6 Anticancer Drug Metabolism : Chemotherapy Resistance and New Therapeutic Approaches

  2018cites this paper
• Glutathione S-transferase π: a potential role in antitumor therapy

  2018cites this paper
• Glutathione S Transferases: Biochemistry, Polymorphism and Role in Colorectal Carcinogenesis

  2017cites this paper
• Selective Inhibitors of Glutathione Transferase P1 with Trioxane Structure as Anticancer Agents

  2015cites this paper
• Cytoprotective and regulatory functions of glutathione S-transferases in cancer cell proliferation and cell death

  2014cites this paper
• Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA).

  2013cites this paper
• Role of genetic polymorphisms of drug metabolising enzymes in idiosyncratic drug reactions In vitro to in vivo translation

  2013cites this paper
• Conformational Heterogeneity and Catalytic Promiscuity in Glutathione Transferases

  2012cites this paper
• Anticancer Drug Metabolism: Chemotherapy Resistance and New Therapeutic Approaches

  2012cites this paper
• Topics on Drug Metabolism

  2012cites this paper
• Regulatory functions of glutathione S-transferase P1-1 unrelated to detoxification

  2011cites this paper
• SÄDE VIIRLAID Novel glutathione analogues and their antioxidant activity

  2011cites this paper
• Evolving therapies and FAK inhibitors for the treatment of cancer.

  2010cites this paper
• Phase 1-2a Multicenter Dose-Ranging Study of Canfosfamide in Combination with Carboplatin and Paclitaxel as First-Line Therapy for Patients with Advanced Non-small Cell Lung Cancer

  2009cites this paper
• Chapter 20 Small-Molecule Inhibitors of Glutathione S-Transferase P1-1 as Anticancer Therapeutic Agents

  2007cites this paper
• Enzymatic and nonenzymatic synthesis of glutathione conjugates: application to the understanding of a parasite's defense system and alternative to the discovery of potent glutathione S-transferase inhibitors.

  2007cites this paper
• Glutathione S-Transferase T1 and M1: Gene Sequence Variation and Functional Genomics

  2007cites this paper
• Design, synthesis and properties of novel powerful antioxidants, glutathione analogues

  2007cites this paper
• ARSTITEADUSKOND FÜSIOLOOGIA INSTITUUT

  2007cites this paper
• Advance in antitumor agents targeting glutathione-S-transferase.

  2006cites this paper
• observations on the Southern Cerrados and their Relationship with the Core Area

  2006cites this paper
• TARTU ÜLIKOOL Arstiteaduskond Biokeemia instituut

  2006cites this paper
• Novel Cytotoxic Agents for Non-small Cell Lung Cancer

  2006cites this paper
• Innovative Rational-Derived, Target-Based and Cytotoxic Therapies for Breast Cancer and Other Malignancies

  2006cites this paper
• [Glucuronyl paclitaxel (Taxol) derivatives as tumor activated prodrugs].

  2005cites this paper
• Targeting NF-κB to Increase the Activity of Cisplatin in Solid Tumors

  2005cites this paper
• Preclinical experience with docetaxel in gastrointestinal cancers.

  2005cites this paper
• Rational Design and Development of Targeted Brain Tumor Therapeutics

  2005cites this paper
• Prodrogues glucuronylées du paclitaxel (Taxol®) activables au niveau des tumeurs

  2005cites this paper
• New cytotoxic agents: a review of the literature.

  2005cites this paper
• TLK-286: a novel glutathione S-transferase-activated prodrug

  2005cites this paper
• Disruption of the glutathione transferase pi class genes.

  2005cites this paper
• Glutathione transferases.

  2005cites this paper
• Tumoral drug metabolism: overview and its implications for cancer therapy.

  2005cites this paper
• Multi‐institutional phase 2 study of TLK286 (TELCYTA™, a glutathione S‐transferase P1‐1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer

  2005cites this paper
• Multi-institutional phase 2 study of TLK286 (TELCYTA™, a glutathione S-transferase P1-1 activated glutathione analog prodrug) in patients with platinum and paclitaxel refractory or resistant ovarian cancer

  2005cites this paper
• The chemistry and biology of inhibitors and pro-drugs targeted to glutathione S-transferases

  2005cites this paper
• The modulation of multidrug resistance in ovarian cancer patients

  2004cites this paper
• Phase 1 Study of TLK286 (Telcyta) Administered Weekly in Advanced Malignancies

  2004cites this paper
• Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug.

  2004cites this paper
• Glutathione analogues in cancer treatment

  2004cites this paper
• Cancer Drugs, Genetic Variation and the Glutathione-S-Transferase Gene Family

  2003cites this paper
• The role of glutathione-S-transferase in anti-cancer drug resistance

  2003cites this paper