Niclosamide Prevents Systemic Sclerosis in a Reactive Oxygen Species–Induced Mouse Model

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Journal of Immunology

• Publication date

  2016-10-15

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.4049/jimmunol.1502482PMID 27613696
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A proteomics approach to identifying key protein targets involved in VEGF inhibitor mediated attenuation of bleomycin‐induced pulmonary fibrosis

  2016cited by this paper
• Animal models of systemic sclerosis.

  2015cited by this paper
• The role of the acquired immune response in systemic sclerosis

  2015cited by this paper
• Pathogenesis of Systemic Sclerosis

  2015cited by this paper
• Inhibition of EGFR Tyrosine Kinase by Erlotinib Prevents Sclerodermatous Graft-Versus-Host Disease in a Mouse Model.

  2015cited by this paper
• Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3.

  2015cited by this paper
• Role of endothelin-1 in the skin fibrosis of systemic sclerosis

  2015cited by this paper
• Sustained β‐catenin activity in dermal fibroblasts promotes fibrosis by up‐regulating expression of extracellular matrix protein‐coding genes

  2015cited by this paper
• Blockage of Wnt/β-catenin signaling by quercetin reduces survival and proliferation of B-1 cells in vitro.

  2015cited by this paper
• Vertical inhibition of PI3K/Akt/mTOR signaling demonstrates in vitro and in vivo anti-fibrotic activity.

  2014cited by this paper
• Inhibition of casein kinase II reduces TGFβ induced fibroblast activation and ameliorates experimental fibrosis

  2014cited by this paper
• IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells

  2014influential reference
• Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension

  2014cited by this paper
• Kinetic study and mechanism of Niclosamide degradation.

  2014cited by this paper
• β-Catenin-regulated myeloid cell adhesion and migration determine wound healing.

  2014cited by this paper
• Reviews and prospectives of signaling pathway analysis in idiopathic pulmonary fibrosis.

  2014cited by this paper
• Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis

  2014cited by this paper
• What causes relapses of autoimmune diseases? The etiological role of autoreactive T cells.

  2013cited by this paper
• STAT3 Regulates Proliferation and Survival of CD8+ T Cells: Enhances Effector Responses to HSV-1 Infection, and Inhibits IL-10+ Regulatory CD8+ T Cells in Autoimmune Uveitis

  2013cited by this paper
• B lymphocytes and B-cell activating factor promote collagen and profibrotic markers expression by dermal fibroblasts in systemic sclerosis

  2013cited by this paper
• Stem cell signaling as a target for novel drug discovery: recent progress in the WNT and Hedgehog pathways

  2013cited by this paper
• Oncostatin M modulates fibroblast function via signal transducers and activators of transcription proteins-3.

  2013cited by this paper
• Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling

  2013cited by this paper
• STAT3 Signaling Induces the Differentiation of Human ICOS+ CD4 T Cells Helping B lymphocytes

  2013cited by this paper
• Evidence for a Functional Thymic Stromal Lymphopoietin Signaling Axis in Fibrotic Lung Disease

  2013cited by this paper
• The differential diagnosis of systemic sclerosis

  2013cited by this paper
• The Wnt antagonists DKK1 and SFRP1 are downregulated by promoter hypermethylation in systemic sclerosis

  2013cited by this paper
• Inhibition of STAT3 by Niclosamide Synergizes with Erlotinib against Head and Neck Cancer

  2013cited by this paper
• Canonical Wnt signalling as a key regulator of fibrogenesis – implications for targeted therapies?

  2013cited by this paper
• Multifaceted roles of GSK-3 and Wnt/β-catenin in hematopoiesis and leukemogenesis: opportunities for therapeutic intervention

  2013cited by this paper
• The capacity of Th2 lymphocytes to deliver B‐cell help requires expression of the transcription factor STAT3

  2013cited by this paper
• Reactive oxygen species-mediated killing of activated fibroblasts by arsenic trioxide ameliorates fibrosis in a murine model of systemic sclerosis.

  2012cited by this paper
• Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling

  2012cited by this paper
• Growth Inhibition of Ovarian Tumor–Initiating Cells by Niclosamide

  2012cited by this paper
• STAT3-mediated signaling dysregulates lung fibroblast-myofibroblast activation and differentiation in UIP/IPF.

  2012cited by this paper
• β-catenin is a central mediator of pro-fibrotic Wnt signaling in systemic sclerosis

  2012cited by this paper
• IL-6 Trans-signaling-STAT3 Pathway Mediates ECM and Cellular Proliferation in Fibroblasts from Hypertrophic Scar

  2012cited by this paper
• Potential immunologic targets for treating fibrosis in systemic sclerosis: a review focused on leukocytes and cytokines.

  2012cited by this paper
• Arsenic Trioxide Prevents Murine Sclerodermatous Graft-versus-Host Disease

  2012cited by this paper
• Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

  2012cited by this paper
• Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells

  2012cited by this paper
• Regulation of mature T cell responses by the Wnt signaling pathway

  2012cited by this paper
• The three R's of lung health and disease: repair, remodeling, and regeneration.

  2011cited by this paper
• MicroRNA-21 expression in CD4+ T cells is regulated by STAT3 and is pathologically involved in Sézary syndrome.

  2011cited by this paper
• Regulation of Ubiquitination-Mediated Protein Degradation by Survival Kinases in Cancer

  2011cited by this paper
• Novel effect of antihelminthic Niclosamide on S100A4-mediated metastatic progression in colon cancer.

  2011cited by this paper
• Interaction of Wingless Protein (Wnt), Transforming Growth Factor-&bgr;1, and Hyaluronan Production in Fetal and Postnatal Fibroblasts

  2010cited by this paper
• Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.

  2010cited by this paper
• Epigenetically altered wound healing in keloid fibroblasts.

  2010cited by this paper
• Epithelial repair mechanisms in the lung.

  2010cited by this paper
• Global Regulator SATB1 Recruits β-Catenin and Regulates TH2 Differentiation in Wnt-Dependent Manner

  2010cited by this paper
• Scleroderma.

  2009cited by this paper
• Selective Oxidation of DNA Topoisomerase 1 Induces Systemic Sclerosis in the Mouse1

  2009cited by this paper
• Gene profiling of keloid fibroblasts shows altered expression in multiple fibrosis-associated pathways.

  2008cited by this paper
• Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud's phenomenon to systemic sclerosis: a twenty-year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis.

  2008cited by this paper
• Green tea polyphenol epigallocatechin-3-gallate suppresses collagen production and proliferation in keloid fibroblasts via inhibition of the STAT3-signaling pathway.

  2008cited by this paper
• Akt blockade downregulates collagen and upregulates MMP1 in human dermal fibroblasts.

  2008cited by this paper
• Loss of STAT3 in CD4+ T Cells Prevents Development of Experimental Autoimmune Diseases

  2008cited by this paper
• Blockade of CD40/CD40 ligand interactions attenuates skin fibrosis and autoimmunity in the tight-skin mouse

  2007cited by this paper
• STAT3 and suppressor of cytokine signaling 3: potential targets in lung inflammatory responses

  2007cited by this paper
• Changes in causes of death in systemic sclerosis, 1972–2002

  2007cited by this paper
• [Pathogenesis of systemic sclerosis].

  2007cited by this paper
• Stat3 contributes to keloid pathogenesis via promoting collagen production, cell proliferation and migration

  2006cited by this paper
• Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids.

  2006cited by this paper
• Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis

  2005cited by this paper
• Fibrotic disease and the TH1/TH2 paradigm

  2004cited by this paper
• Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis.

  2004cited by this paper
• Fibrotic disease and the T(H)1/T(H)2 paradigm.

  2004cited by this paper
• Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis.

  2003cited by this paper
• Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling

  2003cited by this paper
• Differential activation of signal transducer and activator of transcription (STAT)3 and STAT5 and induction of suppressors of cytokine signalling in T(h)1 and T(h)2 cells.

  2003cited by this paper
• Aberrant Wnt/ (cid:1) -Catenin Pathway Activation in Idiopathic Pulmonary Fibrosis

  2003cited by this paper
• Signalling: STATs: transcriptional control and biological impact

  2002cited by this paper
• Oligoclonal T Cell Expansion in the Skin of Patients with Systemic Sclerosis1

  2002cited by this paper
• Criteria for the classification of early systemic sclerosis.

  2001cited by this paper
• B1 cells: similarities and differences with other B cell subsets.

  2001cited by this paper
• A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice.

  1999cited by this paper
• Signal Transducer and Activator of Transcription-3 (STAT3) Is Constitutively Activated in Normal, Self-renewing B-1 Cells but Only Inducibly Expressed in Conventional B Lymphocytes

  1997cited by this paper
• Animal models of systemic sclerosis.

  1994cited by this paper
• Lymphocytes in the skin of patients with progressive systemic sclerosis. Quantification, subtyping, and clinical correlations.

  1984cited by this paper

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  2025cites this paper
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  2025cites this paper
• Machine learning–driven decoding of maternal immune signatures in repeated pregnancy loss

  2025cites this paper
• Phosphodiesterase 4 is overexpressed in human keloids and its inhibition reduces fibroblast activation and skin fibrosis.

  2024cites this paper
• Ketotifen directly modifies the fibrotic response of human skin fibroblasts

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  2024cites this paper
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  2024cites this paper
• Niclosamide attenuates erectile dysfunction and corporal fibrosis via reversal of Smad signaling in diabetic rat model.

  2024cites this paper
• Phosphodiesterase 4 is overexpressed in keloid epidermal scars and its inhibition reduces keratinocyte fibrotic alterations

  2024cites this paper
• Combination of Niclosamide and Pirfenidone Alleviates Pulmonary Fibrosis by Inhibiting Oxidative Stress and MAPK/Nf-κB and STATs Regulated Genes

  2023cites this paper
• Niclosamide inhibits TGF-β1-induced fibrosis of human Tenon's fibroblasts by regulating the MAPK-ERK1/2 pathway.

  2023cites this paper
• Superiority of systemic bleomycin to intradermal HOCl for the study of interstitial lung disease

  2023cites this paper
• Niclosamide as a Promising Therapeutic Player in Human Cancer and Other Diseases

  2022cites this paper
• Pharmacological Inhibition of S100A4 Attenuates Fibroblast Activation and Renal Fibrosis

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  2022cites this paper
• Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double‐blind, placebo‐controlled Phase 2 trial

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• Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection.

  2021cites this paper
• Cytokines as a marker of central nervous system autoantibody associated epilepsy.

  2021cites this paper
• Niclosamide—A promising treatment for COVID‐19

  2021cites this paper
• Pharmacological insights into autophagy modulation in autoimmune diseases

  2021cites this paper
• HYPOCHLOROUS MODEL OF SYSTEMIC SCLEROSIS INDUCTION

  2020cites this paper
• Combined anti-fibrotic and anti-inflammatory properties of JAK-inhibitors on macrophages in vitro and in vivo: perspectives for scleroderma-associated interstitial lung disease.

  2020cites this paper
• The Fibrosis and Immunological Features of Hypochlorous Acid Induced Mouse Model of Systemic Sclerosis

  2019cites this paper
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• Interleukin-13: A promising therapeutic target for autoimmune disease.

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• Niclosamide alleviates pulmonary fibrosis in vitro and in vivo by attenuation of epithelial‐to‐mesenchymal transition, matrix proteins & Wnt/&bgr;‐catenin signaling: A drug repurposing study

  2019cites this paper
• Niclosamide ethanolamine improves diabetes and diabetic kidney disease in mice.

  2018cites this paper
• Withaferin A attenuates bleomycin‐induced scleroderma by targeting FoxO3a and NF‐&kgr;&bgr; signaling: Connecting fibrosis and inflammation

  2018cites this paper
• The Nrf2-Antioxidant Response Element Signaling Pathway Controls Fibrosis and Autoimmunity in Scleroderma

  2018cites this paper
• S100a4 Is Secreted by Alternatively Activated Alveolar Macrophages and Promotes Activation of Lung Fibroblasts in Pulmonary Fibrosis

  2018cites this paper
• Drug repurposing in idiopathic pulmonary fibrosis filtered by a bioinformatics-derived composite score

  2017cites this paper
• Niclosamide: Beyond an antihelminthic drug

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  2017cites this paper