Bioaccumulation of resveratrol metabolites in myocardial tissue is dose-time dependent and related to cardiac hemodynamics in diabetic rats.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  NMCD. Nutrition Metabolism and Cardiovascular Diseases

• Publication date

  2014-04-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.numecd.2013.09.008PMID 24462050
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• In vivo and in vitro metabolism of trans-resveratrol by human gut microbiota.

  2013cited by this paper
• Prevention of diabetes-induced cardiovascular complications upon treatment with antioxidants

  2013cited by this paper
• Pharmacokinetics, tissue distribution and excretion study of resveratrol and its prodrug 3,5,4'-tri-O-acetylresveratrol in rats.

  2013cited by this paper
• Cardiovascular effects and molecular targets of resveratrol.

  2012cited by this paper
• Flavonoids and Related Compounds : Bioavailability and Function

  2012cited by this paper
• Distribution of resveratrol metabolites in liver, adipose tissue, and skeletal muscle in rats fed different doses of this polyphenol.

  2012cited by this paper
• The protective effect of resveratrol on islet insulin secretion and morphology in mice on a high-fat diet.

  2012cited by this paper
• Bioactive compounds in wine: Resveratrol, hydroxytyrosol and melatonin: A review

  2012cited by this paper
• Resveratrol Treatment Reduces Cardiac Progenitor Cell Dysfunction and Prevents Morpho-Functional Ventricular Remodeling in Type-1 Diabetic Rats

  2012influential reference
• What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol

  2011cited by this paper
• Resveratrol in cardiovascular health and disease

  2011cited by this paper
• Clinical trials of resveratrol

  2011cited by this paper
• Metabolites and tissue distribution of resveratrol in the pig.

  2011cited by this paper
• Population Pharmacokinetic Modeling of trans-Resveratrol and Its Glucuronide and Sulfate Conjugates After Oral and Intravenous Administration in Rats

  2011cited by this paper
• Bioavailability of resveratrol

  2011cited by this paper
• The effects of resveratrol on cyclooxygenase-1 and cyclooxygenase-2 mRNA and protein levels in diabetic rat kidneys

  2010cited by this paper
• Quantification of trans-resveratrol and its metabolites in rat plasma and tissues by HPLC.

  2010cited by this paper
• Resveratrol improves left ventricular diastolic relaxation in type 2 diabetes by inhibiting oxidative/nitrative stress: in vivo demonstration with magnetic resonance imaging.

  2010cited by this paper
• Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathy.

  2010cited by this paper
• Hormetic response of resveratrol against cardioprotection.

  2010cited by this paper
• Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

  2010cited by this paper
• Pharmacokinetic study of trans-resveratrol in adult pigs.

  2010cited by this paper
• Resveratrol Potentiates Glucose-stimulated Insulin Secretion in INS-1E β-Cells and Human Islets through a SIRT1-dependent Mechanism*

  2010cited by this paper
• Akt downregulation by flavin oxidase-induced ROS generation mediates dose-dependent endothelial cell damage elicited by natural antioxidants.

  2010cited by this paper
• Plant phenolics and human health: biochemistry, nutrition and pharmacology.

  2009influential reference
• Resveratrol inhibits foam cell formation via NADPH oxidase 1-mediated reactive oxygen species and monocyte chemotactic protein-1

  2009cited by this paper
• Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose.

  2009cited by this paper
• Bioavailability and Metabolism of Resveratrol

  2009cited by this paper
• Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase.

  2007cited by this paper
• Preservation of ventricular performance at early stages of diabetic cardiomyopathy involves changes in myocyte size, number and intercellular coupling

  2007cited by this paper
• Transport, deglycosylation, and metabolism of trans-piceid by small intestinal epithelial cells

  2006cited by this paper
• Therapeutic potential of resveratrol: the in vivo evidence

  2006cited by this paper
• Diabetic cardiomyopathy: the search for a unifying hypothesis.

  2006influential reference
• Distribution of [3H]trans-resveratrol in rat tissues following oral administration

  2006cited by this paper
• Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats.

  2005cited by this paper
• Metabolism and bioavailability of trans-resveratrol.

  2005cited by this paper
• Inhibition of cancer growth by resveratrol is related to its low bioavailability.

  2002cited by this paper
• Assessment of left ventricular relaxation by Doppler echocardiography. Comparison of isovolumic relaxation time and transmitral flow velocities with time constant of isovolumic relaxation.

  1990cited by this paper

• Polyphenols, epigenetics, and methionine metabolism: unlocking therapeutic potential

  2026cites this paper
• Mass spectrometry imaging to evaluate (poly)phenol distribution in animal tissues.

  2025cites this paper
• Resveratrol and Its Nitric Oxide–Donor Hybrid as an Emerging Therapy for Oxidative-Stress-Driven Priapism in Sickle Cell Disease

  2025cites this paper
• Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota

  2024cites this paper
• A comprehensive review on the study of wines and their clinical effect on human health

  2024cites this paper
• Potential role of resveratrol in prevention and therapy of diabetic complications: a critical review

  2024cites this paper
• Red Wine Consumption and the Impact on Cardiovascular Health: The Methodological Barriers of Observational Study Design

  2024cites this paper
• Resveratrol, a Multitasking Molecule That Improves Skeletal Muscle Health

  2023cites this paper
• Nutrikinetics and urinary excretion of phenolic compounds after a 16-week supplementation with a flavanone-rich ingredient.

  2023cites this paper
• A short-term treatment with resveratrol improves the inflammatory conditions of Middle-aged mice skeletal muscles

  2022cites this paper
• The Employment of Genera Vaccinium, Citrus, Olea, and Cynara Polyphenols for the Reduction of Selected Anti-Cancer Drug Side Effects

  2022cites this paper
• Resveratrol in Intestinal Health and Disease: Focusing on Intestinal Barrier

  2022cites this paper
• Resveratrol-Encapsulated Mitochondria-Targeting Liposome Enhances Mitochondrial Respiratory Capacity in Myocardial Cells

  2021cites this paper
• Resveratrol

  2021cites this paper
• Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to COVID-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

  2021cites this paper
• Functional reconstitution of HBV-specific CD8 T cells by in vitro polyphenol treatment in chronic hepatitis B.

  2020cites this paper
• Potential cardio-protective agents: A Resveratrol review (2000-2019).

  2020cites this paper
• The effect of co-administration of berberine, resveratrol, and glibenclamide on xenobiotic metabolizing enzyme activities in diabetic rat liver

  2020cites this paper
• The estrogenic activity of resveratrol: a comprehensive review of in vitro and in vivo evidence and the potential for endocrine disruption

  2020cites this paper
• Long-term resveratrol treatment improves the capillarization in the skeletal muscles of ageing C57BL/6J mice

  2020cites this paper
• Resveratrol and Diabetic Cardiomyopathy: Focusing on the Protective Signaling Mechanisms

  2020cites this paper
• Pharmacological basis and new insights of resveratrol action in the cardiovascular system

  2020influential citation
• Zein nanoparticles improve the oral bioavailability of resveratrol in humans

  2020cites this paper
• The Plant-Derived Compound Resveratrol in Brain Cancer: A Review

  2020cites this paper
• The mechanism(s) of action of antioxidants: From scavenging reactive oxygen/nitrogen species to redox signaling and the generation of bioactive secondary metabolites

  2019cites this paper
• The protection of resveratrol and its combination with glibenclamide, but not berberine on the diabetic hearts against reperfusion-induced arrhythmias: the role of myocardial KATP channel

  2019cites this paper
• The Effects of Resveratrol in Patients with Cardiovascular Disease and Heart Failure: A Narrative Review

  2019cites this paper
• Leveraging the Cardio-Protective and Anticancer Properties of Resveratrol in Cardio-Oncology

  2019cites this paper
• Resveratrol Action on Lipid Metabolism in Cancer

  2019cites this paper
• Bioactive compounds in wines produced in a new area for vitiviniculture in Brazil

  2019influential citation
• Resveratrol Treatment Enhances the Cellular Response to Leptin by Increasing OBRb Content in Palmitate-Induced Steatotic HepG2 Cells

  2019cites this paper
• Amalgamation of polyphenols and probiotics induce health promotion

  2018cites this paper
• Metabolic Screening of Wine (Grapevine) Resveratrol

  2018cites this paper
• n-3 Fatty acids combined with flavan-3-ols prevent steatosis and liver injury in a murine model of NAFLD.

  2018cites this paper
• Metabolism and pharmacokinetics of resveratrol and pterostilbene

  2018cites this paper
• Wine Polyphenols and Health

  2018cites this paper
• Potential Involvement of Peripheral Leptin/STAT3 Signaling in the Effects of Resveratrol and Its Metabolites on Reducing Body Fat Accumulation

  2018cites this paper
• Resveratrol Promotes Nerve Regeneration via Activation of p300 Acetyltransferase-Mediated VEGF Signaling in a Rat Model of Sciatic Nerve Crush Injury

  2018cites this paper
• Resveratrol, Metabolic Syndrome, and Gut Microbiota

  2018cites this paper
• Contribution of Red Wine Consumption to Human Health Protection

  2018cites this paper
• In vivo administration of urolithin A and B prevents the occurrence of cardiac dysfunction in streptozotocin-induced diabetic rats

  2017cites this paper
• Resveratrol alleviates diabetic cardiomyopathy in rats by improving mitochondrial function through PGC-1α deacetylation

  2017cites this paper
• Distribution of trans-resveratrol and its metabolites after acute or sustained administration in mouse heart, brain, and liver.

  2017cites this paper
• Antioxidant effects of resveratrol in the cardiovascular system

  2017cites this paper
• Resveratrol, Potential Therapeutic Interest in Joint Disorders: A Critical Narrative Review

  2017cites this paper
• Determination of trans-resveratrol and its metabolites in rat serum using liquid chromatography with high-resolution time of flight mass spectrometry.

  2016cites this paper
• Resveratrol and Cardiovascular Diseases

  2016cites this paper
• Clinical evidence of resveratrol bioactivity in cardiovascular disease

  2016cites this paper
• Low dose resveratrol improves cerebrovascular function in type 2 diabetes mellitus.

  2016cites this paper
• Parenchymal and Stromal Cells Contribute to Pro-Inflammatory Myocardial Environment at Early Stages of Diabetes: Protective Role of Resveratrol

  2016influential citation
• Urolithins at physiological concentrations affect the levels of pro-inflammatory cytokines and growth factor in cultured cardiac cells in hyperglucidic conditions

  2015cites this paper
• Amino Acid Carbamates As Prodrugs Of Resveratrol

  2015cites this paper
• Myocardial Metabolism in Diabetic Cardiomyopathy: Potential Therapeutic Targets

  2015cites this paper
• Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases.

  2015influential citation
• Therapeutic potential of resveratrol in heart failure

  2015cites this paper
• Pharmacology of natural polyphenols: prodrugs and biochemistry of Resveratrol and Pterostilbene

  2015cites this paper
• Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update

  2014cites this paper
• Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status

  2014cites this paper
• Pharmacokinetics and tissue distribution of pterostilbene in the rat.

  2014cites this paper
• New Water-Soluble Carbamate Ester Derivatives of Resveratrol

  2014cites this paper