Fruitful Decades for Canthin-6-ones from 1952 to 2015: Biosynthesis, Chemistry, and Biological Activities

In this review, more than 60 natural canthin-6-one alkaloids and their structures are considered. The biosynthesis, efficient and classic synthetic approaches, and biological activities of canthin-6-one alkaloids, from 1952 to 2015, are discussed. From an analysis of their structural properties and an investigation of the literature, possible future trends for canthin-6-one alkaloids are proposed. The information reported will be helpful in future research on canthin-6-one alkaloids.

• Publication year

  2016

• Venue

  Molecules

• Publication date

  2016-04-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.3390/molecules21040493PMID 27092482PMCID 6274392
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Synthesis, in vitro antibacterial activities of a series of 3-N-substituted canthin-6-ones.

  2016cited by this paper
• Total synthesis of cordatanine, structural reassignment of drymaritin, and anti-inflammatory activity of synthetic precursors.

  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
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  2015cited by this paper
• Experimental and theoretical study of possible correlation between the electrochemistry of canthin-6-one and the anti-proliferative activity against human cancer stem cells

  2015cited by this paper
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  2015cited by this paper
• Isolation, structural elucidation and cytotoxicity evaluation of a new pentahydroxy-pimarane diterpenoid along with other chemical constituents from Aerva lanata

  2015cited by this paper
• dsDNA, ssDNA, G-quadruplex DNA, and nucleosomal DNA electrochemical screening using canthin-6-one alkaloid-modified electrodes

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2012cited by this paper
• Amarastelline A: A Fluorescent Alkaloid from Quassia amara and Its Properties in Living Cells

  2012cited by this paper
• Modulation of humoral immune responses and inhibition of proinflammatory cytokines and nitric oxide production by 10-methoxycanthin-6-one

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  2011cited by this paper
• Intramolecular [4+2]-Cycloadditionof 5-Amino-Substituted Oxazoles as an Approach toward the Left-HandSegment of Haplophytine

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  2011cited by this paper
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  2010cited by this paper
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  2009cited by this paper
• A convenient approach to the canthin‐4‐one ring system: Total synthesis of the alkaloids tuboflavine and norisotuboflavine

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• Antifungal canthin-6-one series accumulate in lipid droplets and affect fatty acid metabolism in Saccharomyces cerevisiae.

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• Isolation of limonoids and alkaloids fromPhellodendron amurense and their multidrug resistance (MDR) reversal activity

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• Discovery of Novel DNA Gyrase Inhibitors by High-Throughput Virtual Screening

  2007cited by this paper
• Antibacterial activity of two canthin‐6‐one alkaloids from Allium neapolitanum

  2007cited by this paper
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  2007cited by this paper
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  2005cited by this paper
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  2005cited by this paper
• Synthesis and evaluation of beta-carbolinium cations as new antimalarial agents based on pi-delocalized lipophilic cation (DLC) hypothesis.

  2005cited by this paper
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  2005influential reference
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  2004cited by this paper
• A new anti-HIV alkaloid, drymaritin, and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra.

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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
• Leishmanicidal activity of two canthin-6-one alkaloids, two major constituents of Zanthoxylum chiloperone var. angustifolium.

  2002cited by this paper
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  2002cited by this paper
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• Single electron transfer induced total synthesis of canthin-6-one

  1999cited by this paper
• A concise route to isocanthin-6-one

  1998cited by this paper
• New Alkaloids, Picrasidines W, X and Y, from Picrasma quassioides and X-Ray Crystallographic Analysis of Picrasidine Q.

  1994cited by this paper
• Selective Oxidation of Canthines to Canthin-6-ones with Triethylbenzylammonium Permanganate.

  1994cited by this paper
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  1993cited by this paper
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  1991cited by this paper
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  1990cited by this paper
• DDQ Oxidations in the Indole Area. Synthesis of 4-Alkoxy-β-carbolines Including the Natural Products Crenatine and 1-Methoxycanthin-6-one.

  1989cited by this paper
• DDQ oxidations in the indole area. Synthesis of 4-alkoxy-.beta.-carbolines including the natural products crenatine and 1-methoxycanthin-6-one

  1989cited by this paper
• Evidence for involvement of ketoglutarate in the biosynthesis of Canthin-6-one from cell cultures of Ailanthus altissima

  1988cited by this paper
• Synthesis of 1-methoxy canthine-6-one

  1988cited by this paper
• Synthesis of 1-Methoxycanthine-6-one (VIII).

  1988cited by this paper
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  1975cited by this paper
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  1966cited by this paper
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  1952cited by this paper

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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
• Synthesis of Canthin-4-ones and Isocanthin-4-ones via B Ring Construction

  2024cites this paper
• DNA Damage-Inducing 10-Methoxy-canthin-6-one (Mtx-C) Promotes Cell Cycle Arrest in G2/M and Myeloid Differentiation of Acute Myeloid Leukemias and Leukemic Stem Cells

  2024cites this paper
• Canthin-6-one analogs block Newcastle disease virus proliferation via suppressing the Akt and ERK pathways

  2024cites this paper
• Canthin-6-One Inhibits Developmental and Tumour-Associated Angiogenesis in Zebrafish

  2024cites this paper
• Methyl Canthin-6-one-2-carboxylate Restrains the Migration/Invasion Properties of Fibroblast-like Synoviocytes by Suppressing the Hippo/YAP Signaling Pathway

  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Huberine, a New Canthin-6-One Alkaloid from the Bark of Picrolemma huberi

  2018cites this paper
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  2017cites this paper
• Synthesis of Benzoannelated Canthin-6-One Analogs

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Bioelectrochemical monitoring of soluble guanylate cyclase inhibition by the natural β-carboline canthin-6-one

  2017cites this paper
• A one-pot, two-step synthesis of 3-deazacanthin-4-ones via sequential Pd-catalyzed Suzuki-Miyaura and Cu-catalyzed Buchwald-Hartwig reactions

  2017cites this paper