Transduction of cell and matrix geometric cues by the actin cytoskeleton.

Engineered culture substrates have proven invaluable for investigating the role of cell and extracellular matrix geometry in governing cell behavior. While the mechanisms relating geometry to phenotype are complex, it is clear that the actin cytoskeleton plays a key role in integrating geometric inputs and transducing these cues into intracellular signals that drive downstream biology. Here, we review recent progress in elucidating the role of the cell and matrix geometry in regulating actin cytoskeletal architecture and mechanics. We address new developments in traditional two-dimensional culture paradigms and discuss efforts to extend these advances to three-dimensional systems, ranging from nanotextured surfaces to microtopographical systems (e.g. channels) to fully three-dimensional matrices.

• Publication year

  2020

• Venue

  Current Opinion in Cell Biology

• Publication date

  2020-10-16

• Fields of study

  Biology, Medicine, Materials Science, Engineering

• Identifiers
  DOI 10.1016/j.ceb.2020.08.016PMID 33075689PMCID PMC7925337
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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