Effective utilization of food wastes: Bioactivity of grape seed extraction and its application in food industry

Abstract Grape seeds are rich in nutrients possessing high nutritional and medicinal value. Grape seed extract (GSE) mainly contains 15 phenolic compounds, such as (+)-catechin, (−)-epicatechin, proanthocyanidin, gallate, flavonols and others. Several studies on GSE and its components indicated that it has pharmacological attributes, such as antioxidation, anti-inflammation, anticancer, neuroprotection, lowering lipid, bacteriostatic, and reduced blood pressure. This article reviewed the research progress on the bioactivity of GSE and its application in foods in order to provide a reference for future studies on the development and utilization of grape seeds.

• Publication year

  2020

• Venue

  Journal of Functional Foods

• Publication date

  2020-10-01

• Fields of study

  Agricultural and Food Sciences, Chemistry

• Identifiers
  DOI 10.1016/j.jff.2020.104113
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Protective effects of grape seed proanthocyanidins against iron overload-induced renal oxidative damage in rats.

  2020cited by this paper
• Proanthocyanidins in grape seeds: An updated review of their health benefits and potential uses in the food industry

  2020cited by this paper
• Characterization of the microbial community composition in Italian Cinta Senese sausages dry-fermented with natural extracts as alternatives to sodium nitrite.

  2020cited by this paper
• Grape seed proanthocyanidin extract ameliorates hepatic lipid accumulation and inflammation in grass carp (Ctenopharyngodon idella)

  2020cited by this paper
• L-Aspartate, L-Ornithine and L-Ornithine-L-Aspartate (LOLA) and Their Impact on Brain Energy Metabolism

  2020cited by this paper
• Effects of rosemary extract, grape seed extract and green tea polyphenol on the formation of N ‐nitrosamines and quality of western‐style smoked sausage

  2020cited by this paper
• Incorporating nisin and grape seed extract in chitosan-gelatine edible coating and its effect on cold storage of fresh pork

  2020cited by this paper
• Effect of Black Grape Seed Extract (Vitis vinifera) on Biofilm Formation of Methicillin-Resistant Staphylococcus aureus and Staphylococcus haemolyticus

  2019cited by this paper
• Effects of Grape Seed Proanthocyanidin Extract on Vascular Endothelial Function in Participants with Prehypertension: A Randomized, Double-Blind, Placebo-Controlled Study

  2019cited by this paper
• Grape Seed Polyphenols Ameliorated Dextran Sulfate Sodium-Induced Colitis via Suppression of Inflammation and Apoptosis

  2019cited by this paper
• Grape Seed Proanthocyanidin Extract Mitigates Titanium Dioxide Nanoparticle (TiO2-NPs)–Induced Hepatotoxicity Through TLR-4/NF-κB Signaling Pathway

  2019cited by this paper
• Grape Seed Extract Eliminates Visceral Allodynia and Colonic Hyperpermeability Induced by Repeated Water Avoidance Stress in Rats

  2019cited by this paper
• Grape Seeds Proanthocyanidins: An Overview of In Vivo Bioactivity in Animal Models

  2019cited by this paper
• Grape seed flour intake decreases adiposity gain in high-fat-diet induced obese mice by activating thermogenesis

  2019cited by this paper
• Phenolic-rich Petit Suisse cheese manufactured with organic Bordeaux grape juice, skin, and seed extract: Technological, sensory, and functional properties

  2019cited by this paper
• Antiproliferative and cytotoxic effects of grape pomace and grape seed extracts on colorectal cancer cell lines

  2019cited by this paper
• Natural extracts from grape seed and stem by-products in combination with colloidal silver as alternative preservatives to SO2 for white wines: Effects on chemical composition and sensorial properties.

  2019cited by this paper
• The possible neuroprotective role of grape seed extract on the histopathological changes of the cerebellar cortex of rats prenatally exposed to Valproic Acid: animal model of autism.

  2019cited by this paper
• Anti-inflammatory effect of grape (Vitis vinifera L.) seed extract through the downregulation of NF-κB and MAPK pathways in LPS-induced RAW264.7 macrophages

  2019cited by this paper
• Pro-Apoptotic Effect of Grape Seed Extract on MCF-7 Involves Transient Increase of Gap Junction Intercellular Communication and Cx43 Up-Regulation: A Mechanism of Chemoprevention

  2019cited by this paper
• Antidiabetic activity of root tubers of Asparagus gonoclados Baker in streptozotocin induced diabetic rats.

  2019cited by this paper
• Pretreatment of Grape Seed Proanthocyanidin Extract Exerts Neuroprotective Effect in Murine Model of Neonatal Hypoxic-ischemic Brain Injury by Its Antiapoptotic Property

  2019cited by this paper
• Neuroprotective benefits of grape seed and skin extract in a mouse model of Parkinson’s disease

  2019cited by this paper
• Vacuum impregnation of fish gelatin combined with grape seed extract inhibits protein oxidation and degradation of chilled tilapia fillets.

  2019cited by this paper
• Grape seeds proanthocyanidin extract ameliorates Ehrlich solid tumor induced renal tissue and DNA damage in mice.

  2019cited by this paper
• Effect of grape seed extract on heat resistance of Clostridium perfringens vegetative cells in sous vide processed ground beef.

  2019cited by this paper
• Characterization in vitro potency of biological active fractions of seeds, skins and flesh from selected Vitis vinifera L. cultivars and interspecific hybrids

  2019cited by this paper
• Grape seed proanthocyanidin inhibits monocrotaline-induced pulmonary arterial hypertension via attenuating inflammation: in vivo and in vitro studies.

  2019cited by this paper
• Oenological potential of extracts from winery and cooperage by-products in combination with colloidal silver as natural substitutes to sulphur dioxide.

  2019cited by this paper
• Elucidating antimicrobial mechanism of nisin and grape seed extract against Listeria monocytogenes in broth and on shrimp through NMR-based metabolomics approach.

  2019cited by this paper
• Grape Seed Procyanidin B2 Protects Porcine Ovarian Granulosa Cells against Oxidative Stress-Induced Apoptosis by Upregulating let-7a Expression

  2019cited by this paper
• Antimicrobial effectiveness of grape seed extract against Enterococcus faecalis biofilm: A Confocal Laser Scanning Microscopy analysis.

  2019cited by this paper
• Grape Seed Proanthocyanidins Induce Autophagy and Modulate Survivin in HepG2 Cells and Inhibit Xenograft Tumor Growth in Vivo

  2019cited by this paper
• Grape Seed Proanthocyanidin Extract Inhibits Human Esophageal Squamous Cancerous Cell Line ECA109 via the NF-κB Signaling Pathway

  2018cited by this paper
• Molecular characterization of the grape seeds extract’s effect against chemically induced liver cancer: In vivo and in vitro analyses

  2018cited by this paper
• Grape seed proanthocyanidin reverses pulmonary vascular remodeling in monocrotaline-induced pulmonary arterial hypertension by down-regulating HSP70.

  2018cited by this paper
• Neuro- and nephroprotective effect of grape seed proanthocyanidin extract against carboplatin and thalidomide through modulation of inflammation, tumor suppressor protein p53, neurotransmitters, oxidative stress and histology

  2018cited by this paper
• Tanshinone IIA improves hypoxic ischemic encephalopathy through TLR-4-mediated NF-κB signal pathway

  2018cited by this paper
• Effect of natural antioxidants from grape seed and chestnut in combination with hydroxytyrosol, as sodium nitrite substitutes in Cinta Senese dry-fermented sausages.

  2018cited by this paper
• A novel and compact review on the role of oxidative stress in female reproduction

  2018cited by this paper
• Connexin 43 is an independent predictor of patient outcome in breast cancer patients

  2018cited by this paper
• Oligomeric proanthocyanidins (OPCs) from grape seed extract suppress the activity of ABC transporters in overcoming chemoresistance in colorectal cancer cells.

  2018cited by this paper
• Recent advances on polysaccharides, lipids and protein based edible films and coatings: A review.

  2017cited by this paper
• Grape seed proanthocyanidins inhibit the proliferation, migration and invasion of tongue squamous cell carcinoma cells through suppressing the protein kinase B/nuclear factor-κB signaling pathway

  2017cited by this paper
• Masquelier’s grape seed extract: from basic flavonoid research to a well-characterized food supplement with health benefits

  2017cited by this paper
• Evaluation of peanut skin and grape seed extracts to inhibit growth of foodborne pathogens

  2017cited by this paper
• Mathematical modeling of gallic acid release from chitosan films with grape seed extract and carvacrol.

  2017cited by this paper
• Grape seed extract: the first protein‐based fining agent endogenous to grapes

  2017cited by this paper
• Grape-seed proanthocyanidins inhibit the lipopolysaccharide-induced inflammatory mediator expression in RAW264.7 macrophages by suppressing MAPK and NF-κb signal pathways.

  2016cited by this paper
• Antioxidant and Hepatoprotective Effects of Procyanidins from Wild Grape (Vitis amurensis) Seeds in Ethanol-Induced Cells and Rats

  2016cited by this paper
• Neuroprotection of Grape Seed Extract and Pyridoxine against Triton-Induced Neurotoxicity

  2016cited by this paper
• MicroRNA-19a/b mediates grape seed procyanidin extract-induced anti-neoplastic effects against lung cancer.

  2016cited by this paper
• Neuroprotective effect of grape seed extract against cadmium toxicity in male albino rats

  2016cited by this paper
• Hepatoprotective effect of grape seed oil against carbon tetrachloride induced oxidative stress in liver of γ-irradiated rat.

  2016cited by this paper
• Natural Antimicrobials and Oral Microorganisms: A Systematic Review on Herbal Interventions for the Eradication of Multispecies Oral Biofilms

  2016cited by this paper
• Grape Seed Procyanidins and Cholestyramine Differentially Alter Bile Acid and Cholesterol Homeostatic Gene Expression in Mouse Intestine and Liver

  2016cited by this paper
• Grape seed flavanols decrease blood pressure via Sirt-1 and confer a vasoprotective pattern in rats

  2016cited by this paper
• Review of the Pharmacological Effects of Vitis vinifera (Grape) and its Bioactive Constituents: An Update

  2016cited by this paper
• Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance

  2015cited by this paper
• Preparation and characterization of edible myofibrillar protein-based film incorporated with grape seed procyanidins and green tea polyphenol

  2015cited by this paper
• Antimicrobial efficacy of grape seed extract against Escherichia coli O157:H7 growth, motility and Shiga toxin production

  2015cited by this paper
• Evaluation of antimicrobial effectiveness and dentine mechanical properties after use of chemical and natural auxiliary irrigants.

  2015cited by this paper
• STAT3 and sphingosine-1-phosphate in inflammation-associated colorectal cancer.

  2014cited by this paper
• Inflammation in pulmonary hypertension: what we know and what we could logically and safely target first.

  2014cited by this paper
• Hypolipidemic action of chrysin on Triton WR-1339-induced hyperlipidemia in female C57BL/6 mice

  2014cited by this paper
• Titanium dioxide nanoparticles: a review of current toxicological data

  2013cited by this paper
• CRF Induces Intestinal Epithelial Barrier Injury via the Release of Mast Cell Proteases and TNF-α

  2012cited by this paper
• Grape seed proanthocyanidin extracts enhance endothelial nitric oxide synthase expression through 5'-AMP activated protein kinase/Surtuin 1-Krüpple like factor 2 pathway and modulate blood pressure in ouabain induced hypertensive rats.

  2012cited by this paper
• Green tea and grape seed extracts — Potential applications in food safety and quality

  2011cited by this paper
• Inflammation 2010: new adventures of an old flame.

  2010cited by this paper
• Endothelial dysfunction and vascular disease

  2009cited by this paper
• Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid

  2007cited by this paper
• Chemiluminescent screening of quenching effects of natural colorants against reactive oxygen species: Evaluation of grape seed, monascus, gardenia and red radish extracts as multi-functional food additives

  2007cited by this paper
• Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.

  2005cited by this paper
• Endothelial KLF2 links local arterial shear stress levels to the expression of vascular tone-regulating genes.

  2005cited by this paper
• Endothelial nitric oxide synthase: insight into cell-specific gene regulation in the vascular endothelium

  2005cited by this paper
• Mechanisms for the Inhibition of DNA Methyltransferases by Tea Catechins and Bioflavonoids

  2005cited by this paper
• The antioxidative function, preventive action on disease and utilization of proanthocyanidins

  2004cited by this paper
• Expression and activity of Apaf1 and caspase-9 in granulosa cells during follicular atresia in pig ovaries.

  2003cited by this paper
• Inhibition of lipopolysaccharide‐inducible nitric oxide synthase, TNF‐α and COX‐2 expression by sauchinone effects on I‐κBα phosphorylation, C/EBP and AP‐1 activation

  2003cited by this paper
• 2-Bromopropane induces DNA damage, impairs functional antioxidant cellular defenses, and enhances the lipid peroxidation process in primary cultures of rat Leydig cells.

  2002cited by this paper
• Role of intracellular thiol depletion, mitochondrial dysfunction and reactive oxygen species in Salvia miltiorrhiza-induced apoptosis in human hepatoma HepG2 cells.

  2001cited by this paper
• Proanthocyanidins and human health: systemic effects and local effects in the gut.

  2000cited by this paper
• Hepatic chemiluminescence and lipid peroxidation in mild iron overload.

  1992cited by this paper

• Chemical Composition, Antioxidant and Immunomodulatory Properties of Syrah Grape Seed Extract.

  2026cites this paper
• FATTY ACID COMPOSITION AND BIOLOGICAL ACTIVITIES OF VITIS VINIFERA L. (ANTEP KARASI) SEED OIL

  2025cites this paper
• Sustainable valorisation of postharvest waste for disease control and quality preservation in fruits and vegetables.

  2025cites this paper
• Occurrence and management of Campylobacter sp. isolated from milk and milk products by natural extracts and its application in Karish cheese

  2025cites this paper
• Exploration of Hypolipidemic Effects of Sterols from Pleurotus tuber-regium(Fr.) Sing Sclerotium

  2025cites this paper
• Valorization of Grape By-Products: Insights into Sustainable Industrial and Nutraceutical Applications

  2025cites this paper
• A Review of the Chemical Composition and Biological Activities of Sugarcane: Potential Medicinal Value and Sustainable Development

  2025cites this paper
• Enhancing bioactive stability and applications: microencapsulation in fruit and vegetable waste valorization

  2025cites this paper
• Interaction of gibberellic acid, potassium nitrate and role of pollen sources on physicobiochemical traits of grape

  2025cites this paper
• Whole Wheat Bread with Grape Seed Powder

  2025cites this paper
• Effects of grape seed proanthocyanidin on the conformation and functional properties of mutton myofibrillar protein under hydroxyl radical-induced oxidative stress

  2025cites this paper
• Grape seeds: nutritional value, health advantages, and industrial applications

  2025cites this paper
• Effect of Acute Consumption of Crackers Enriched with Grape Seed Flour or Barley Flour with Added β-Glucan on Biomarkers of Postprandial Glycemia, Lipidemia, and Oxidative Stress: A Crossover Study

  2024cites this paper
• Synergistic enhancement of osteogenesis: silica nanoparticles and proanthocyanidin on bioinspired nanofibrous scaffolds for craniofacial bone regeneration

  2024cites this paper
• Effects of Red Grape (Vitis Vinifera L.) Pomace Powder on Physicochemical and Textural Properties of Sucuk

  2024cites this paper
• Mitigating Acetaminophen-Induced Kidney Injury: The Protective Role of Grape Seed and Peanut Skin Extracts through the iNOS/CYP2E1 Pathway

  2024cites this paper
• Grape Pomace—Advances in Its Bioactivity, Health Benefits, and Food Applications

  2024influential citation
• Effects of different temperatures on electric oven drying of myrtle (Eugenia gracillima Kiaersk.) seeds modified by High Hydrostatic Pressure (HHP)

  2023cites this paper
• Phytochemicals Derived from Agricultural Residues and Their Valuable Properties and Applications

  2023cites this paper
• Sustainable Extraction Methods Affect Metabolomics and Oxidative Stability of Myrtle Seed Oils Obtained from Myrtle Liqueur By-Products: An Electron Paramagnetic Resonance and Mass Spectrometry Approach

  2023cites this paper
• Extraction and purification of grape seed polysaccharides using pH-switchable deep eutectic solvents-based three-phase partitioning.

  2023cites this paper
• A Review on Berry Seeds—A Special Emphasis on Their Chemical Content and Health-Promoting Properties

  2023cites this paper
• Effects of free and encapsulated Siah‐e‐Samarghandi grape seed extract on the physicochemical, textural, microbial, and sensorial properties of UF‐Feta cheese

  2023cites this paper
• Winemaking: “With One Stone, Two Birds”? A Holistic Review of the Bio-Functional Compounds, Applications and Health Benefits of Wine and Wineries’ By-Products

  2023cites this paper
• Exploratory analysis of bioactive compounds and antioxidant potential of grape (Vitis vinifera) pomace

  2022cites this paper
• Sources of plant extracts

  2022cites this paper
• Grape seed proanthocyanidin extract inhibits DNA and protein damage and labile iron, enzyme, and cancer cell activities

  2022cites this paper
• Triple-action packaging: Food protection and monitoring enabled by agri-food side streams

  2022cites this paper
• Effects of grape seed extract on meat color and premature browning of meat patties in high-oxygen packaging

  2022cites this paper
• Computation Screening of Multi-Target Antidiabetic Properties of Phytochemicals in Common Edible Mediterranean Plants

  2022cites this paper
• Recent advances on preparative LC approaches for polyphenol separation and purification: Their sources and main activities

  2022cites this paper
• Bioactive Compounds, Health Benefits and Food Applications of Grape

  2022cites this paper
• An Updated Review on Prebiotics: Insights on Potentials of Food Seeds Waste as Source of Potential Prebiotics

  2022cites this paper
• Chemical composition and mineral content of Black Borgoña (Vitis labrusca L.) grapes, pomace and seeds, and effects of conventional and non-conventional extraction methods on their antioxidant properties

  2022cites this paper
• Encapsulation of phenolic compounds by spray drying of Ancellotta and Aspirant Bouchet wines to produce powders with potential use as natural food colorants

  2022cites this paper
• High-Throughput Quantification of 32 Bioactive Antioxidant Phenolic Compounds in Grapes, Wines and Vinification Byproducts by LC–MS/MS

  2021cites this paper
• Valorized Food Processing By-Products in the EU: Finding the Balance between Safety, Nutrition, and Sustainability

  2021cites this paper
• Influence of grape seed extract on suppression of biogenic amine accumulation, chemical and color traits of wet tarhana during fermentation

  2021cites this paper
• Immunostimulatory Potential of Fruits and Their Extracts in Poultry

  2021cites this paper
• Prospects for Proanthocyanidins from Grape Seed: Extraction Technologies and Diverse Bioactivity

  2021cites this paper
• Microencapsulation of polyphenolic compounds recovered from red wine lees: process optimization and nutraceutical study

  2021cites this paper
• Sustainable Recovery of Preservative and Bioactive Compounds from Food Industry Bioresidues

  2021cites this paper
• Effect of fortification of set‐type yoghurt with different plant extracts on its physicochemical, rheological, textural and sensory properties during storage

  2021cites this paper
• The Effects of Grape, pomegranate, Sesame Seed Powder and Their Oils on Probiotic Ice Cream: Total phenolic contents, antioxidant activity and probiotic viability

  2021cites this paper
• Flash extraction: An ultra-rapid technique for acquiring bioactive compounds from plant materials

  2021cites this paper
• Bioactive Compounds from Agricultural Residues, Their Obtaining Techniques, and the Antimicrobial Effect as Postharvest Additives

  2021cites this paper
• Different irrigation strategies affect proximate composition and Different irrigation strategies affect proximate composition and fatty acid profiles of grape seeds under semi-arid conditions fatty acid profiles of grape seeds under semi-arid conditions

  year unknowncites this paper