Association between breast milk adipokines with growth in breast feeding infants, a systematic review and meta-analysis

Abstract Objectives Breast milk adipokines are associated with growth, body mass index (BMI) and weight gain in infants. In this study, the effect of breastmilk adipokines (leptin and adiponectin) on the BMI and weight gain of breast-fed infants was evaluated using systematic review and meta-analysis. Materials and methods We used PRISMA checklist for carrying out this study. 752 articles were collected from the database searching and other sources from 1994 to April 2019. According to the criteria in the study, 25 articles remained for evaluation. Eight papers were related to the effect of breast milk leptin on weight gain and BMI of infants that were evaluated by meta-analyzing. The adiponectin articles were surveyed by systematic review. Results There was no significant publication bias in the meta-analysis study. The results of random-effect model indicated a reverse and significant correlation between breastmilk leptin with weight gain and BMI (r=−0.331). The adiponectin level in breast milk was associated with the BMI and weight gain of infants. Conclusions Meta-analysis indicated a significant inverse correlation between breastmilk leptin with weight gain and BMI in infants; furthermore, the systematic review study expressed significant correlation between breast milk adiponectin with growth (BMI and weight gain) in infants. Öz Amaç Anne sütü adipokinleri bebeklerde büyüme, vücut kitle indeksi (VKİ) ve kilo alımı ile ilişkilidir. Bu çalışmada anne sütü adipokinlerinin (leptin ve adiponektin) anne sütüyle beslenen bebeklerin vücut kitle indeksi ve kilo alımı üzerindeki etkisi sistematik derleme ve meta-analiz kullanılarak değerlendirildi. Gereç ve Yöntemler Bu çalışmayı gerçekleştirmek için PRISMA kontrol listesini kullandık. Veri tabanı taramasından ve diğer kaynaklardan 1994’ten Nisan 2019’a kadar 752 makale toplanmıştır. Çalışmadaki kriterlere göre değerlendirilmek üzere yirmi beş makale kalmıştır. Meta-analiz ile değerlendirilen sekiz makale, anne sütü leptininin bebeklerin kilo alımı ve BMI üzerindeki etkisi ile ilgilidir. Adiponektin makaleleri sistematik bir inceleme ile incelenmiştir. Bulgular Meta-analiz çalışmasında önemli bir yayın yanlılığı yoktu. Rastgele etki modelinin sonuçları, anne sütü leptini ile kilo alımı ve VKİ arasında ters ve anlamlı bir korelasyon olduğunu gösterdi (r=−0.331). Anne sütündeki adiponektin düzeyi, bebeklerin vücut kitle indeksi ve kilo alımı ile ilişkiliydi. Sonuç Meta-analiz bebeklerde anne sütü leptini ile kilo alımı ve VKİ arasında anlamlı bir ters ilişki olduğunu gösterdi; ayrıca, sistematik gözden geçirme çalışması bebeklerde anne sütü adiponektini ile büyüme (VKİ ve kilo artışı) arasında önemli bir korelasyon olduğunu ortaya koymuştur.

• Publication year

  2020

• Venue

  Turkish Journal of Biochemistry

• Publication date

  2020-10-09

• Fields of study

  Medicine

• Identifiers
  DOI 10.1515/tjb-2020-0178
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• MK2 Is Required for Neutrophil-Derived ROS Production and Inflammatory Bowel Disease

  2020cited by this paper
• Adiponectin, leptin and insulin in breast milk: associations with maternal characteristics and infant body composition in the first year of life

  2018influential reference
• Duration of Breastfeeding, but Not Timing of Solid Food, Reduces the Risk of Overweight and Obesity in Children Aged 24 to 36 Months: Findings from an Australian Cohort Study

  2018cited by this paper
• Excessive Weight Gain Followed by Catch-Down in Exclusively Breastfed Infants: An Exploratory Study

  2018cited by this paper
• Do the adiponectin and leptin levels in preterm and term breast milk samples relate to infants’ short-term growth?

  2018cited by this paper
• Human Milk Adiponectin and Leptin and Infant Body Composition over the First 12 Months of Lactation

  2018cited by this paper
• The Influence of Maternal Obesity and Breastfeeding on Infant Appetite- and Growth-Related Hormone Concentrations: The SKOT Cohort Studies

  2018cited by this paper
• The adiponectin promoter activator NP-1 induces high levels of circulating TNFα and weight loss in obese (fa/fa) Zucker rats

  2018cited by this paper
• Maternal Serum and Breast Milk Adiponectin: The Association with Infant Adiposity Development

  2018cited by this paper
• Human Milk: An Ideal Food for Nutrition of Preterm Newborn

  2018cited by this paper
• Associations of breast milk adiponectin, leptin, insulin and ghrelin with maternal characteristics and early infant growth: a longitudinal study

  2018cited by this paper
• Associations between Maternal Body Composition and Appetite Hormones and Macronutrients in Human Milk

  2017cited by this paper
• Associations between human breast milk hormones and adipocytokines and infant growth and body composition in the first 6 months of life

  2017cited by this paper
• Relation of Breast Milk Adiponectin Level to Infant Growth

  2017influential reference
• Mother and Infant Body Mass Index, Breast Milk Leptin and Their Serum Leptin Values

  2016cited by this paper
• Lower levels of human milk adiponectin predict offspring weight for age: a study in a lean population of Filipinos.

  2016cited by this paper
• Breast milk leptin and adiponectin in relation to infant body composition up to 2 years

  2015cited by this paper
• Maternal Characteristics Associated with Milk Leptin Content in a Sample of Filipino Women and Associations with Infant Weight for Age

  2015cited by this paper
• Adiponectin and energy homeostasis

  2014cited by this paper
• New Insight into Adiponectin Role in Obesity and Obesity-Related Diseases

  2014cited by this paper
• The Study of Breast Milk IGF-1, Leptin, Ghrelin and Adiponectin Levels as Possible Reasons of High Weight Gain in Breast-Fed Infants

  2014cited by this paper
• Comparative measurement of ghrelin, leptin, adiponectin, EGF and IGF-1 in breast milk of mothers with overweight/obese and normal-weight infants

  2014cited by this paper
• Leptin signaling and leptin resistance

  2013cited by this paper
• Leptin and Adiponectin: Emerging Therapeutic Targets in Breast Cancer

  2013cited by this paper
• The relationship between ghrelin and adiponectin levels in breast milk and infant serum and growth of infants during early postnatal life

  2012cited by this paper
• Human Milk Adiponectin Affects Infant Weight Trajectory During the Second Year of Life

  2012influential reference
• Adiponectin in breast milk: relation to serum adiponectin concentration in lactating mothers and their infants

  2012cited by this paper
• FOSL2 promotes leptin gene expression in human and mouse adipocytes.

  2012cited by this paper
• Relationship of insulin, glucose, leptin, IL‐6 and TNF‐α in human breast milk with infant growth and body composition

  2012cited by this paper
• Resistin and leptin in breast milk and infants in early life.

  2012cited by this paper
• Adiponectin Action: A Combination of Endocrine and Autocrine/Paracrine Effects

  2011cited by this paper
• Leptin in Maternal Serum and Breast Milk: Association With Infants' Body Weight Gain in a Longitudinal Study Over 6 Months of Lactation

  2011cited by this paper
• Breastmilk ghrelin, leptin, and fat levels changing foremilk to hindmilk: is that important for self-control of feeding?

  2011cited by this paper
• Adiponectin, AFABP, and Leptin in Human Breast Milk During 12 Months of Lactation

  2011cited by this paper
• Role of adiponectin and leptin on body development in infants during the first year of life

  2010cited by this paper
• Characteristics and potential functions of human milk adiponectin.

  2010cited by this paper
• Evaluation of leptin in breast milk, lactating mothers and their infants

  2010cited by this paper
• The relation of serum ghrelin, leptin and insulin levels to the growth patterns and feeding characteristics in breast-fed versus formula-fed infants.

  2010cited by this paper
• Can hormones contained in mothers’ milk account for the beneficial effect of breast‐feeding on obesity in children?

  2009cited by this paper
• The relationship between breast milk leptin and neonatal weight gain

  2009cited by this paper
• Human Milk Adiponectin Is Associated with Infant Growth in Two Independent Cohorts

  2009influential reference
• Plasma adiponectin complexes have distinct biochemical characteristics.

  2008cited by this paper
• Mechanisms of leptin action and leptin resistance.

  2008cited by this paper
• Leptin Stimulates Both JAK2-dependent and JAK2-independent Signaling Pathways*

  2008cited by this paper
• Adipokines in Human Milk and Risk of Overweight in Early Childhood: A Prospective Cohort Study

  2007influential reference
• The Long Form of the Leptin Receptor Regulates STAT5 and Ribosomal Protein S6 via Alternate Mechanisms*

  2007cited by this paper
• Phosphorylation of Jak2 on Ser523 InhibitsJak2-Dependent Leptin ReceptorSignaling

  2006cited by this paper
• Mechanisms regulating energy metabolism by adiponectin in obesity and diabetes.

  2006cited by this paper
• A Physiological Role of Breast Milk Leptin in Body Weight Control in Developing Infants

  2006cited by this paper
• Longitudinal Investigation of the Relationship between Breast Milk Leptin Levels and Growth in Breast-fed Infants

  2005cited by this paper
• Adiponectin and adiponectin receptors.

  2005cited by this paper
• Plasma adiponectin levels in newborns are higher than those in adults and positively correlated with birth weight

  2004cited by this paper
• Adiponectin levels in the first two years of life in a prospective cohort: relations with weight gain, leptin levels and insulin sensitivity.

  2004cited by this paper
• Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells

  2004cited by this paper
• Adiponectin and the development of type 2 diabetes: the atherosclerosis risk in communities study.

  2004cited by this paper
• Thiol‐mediated protein retention in the endoplasmic reticulum: the role of ERp44

  2003cited by this paper
• Obesity, adiponectin and vascular inflammatory disease

  2003cited by this paper
• Leptin levels in breast‐fed and formula‐fed infants

  2002cited by this paper
• Breast milk leptin: its relationship to maternal and infant adiposity.

  2002cited by this paper
• The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

  2001cited by this paper
• Activation of Downstream Signals by the Long Form of the Leptin Receptor*

  2000cited by this paper
• Breast Milk Leptin Concentrations in Initial and Terminal Milk Samples: Relationships to Maternal and Infant Plasma Leptin Concentrations, Adiposity, Serum Glucose, Insulin, Lipid and Lipoprotein Levels

  2000cited by this paper
• Presence of leptin in colostrum and/or breast milk from lactating mothers: a potential role in the regulation of neonatal food intake.

  1997cited by this paper
• Leptin is present in human milk and is related to maternal plasma leptin concentration and adiposity.

  1997cited by this paper
• Iranian Journal of Basic Medical Sciences Adiponectin: an Adipokine with Protective Features against Metabolic Syndrome

  year unknowncited by this paper

• Influence of Lactation Stage on Content of Neurotrophic Factors, Leptin, and Insulin in Human Milk

  2024cites this paper
• Breast Milk MicroRNAs Related to Leptin and Adiponectin Function Can Be Modulated by Maternal Diet and Influence Offspring Phenotype in Rats

  2022cites this paper
• Of mammals and milk: how maternal stress affects nursing offspring

  2021cites this paper
• Perbedaan Gizi pada Bayi: Membandingkan Profil Karbohidrat dan Lipid antara Bayi dengan Status Gizi Normal dan Obesitas Nutritional Difference in Infants: Contrasting Carbohydrate and Lipid Profiles between Normal and Obese States

  year unknowncites this paper