Towards an Insulin Resistant Adipose Model on a Chip

No abstract is available for this paper.

• Publication year

  2020

• Venue

  Cellular and Molecular Bioengineering

• Publication date

  2020-07-14

• Fields of study

  Medicine, Chemistry, Engineering

• Identifiers
  DOI 10.1007/s12195-020-00636-xPMID 33643468PMCID PMC7878591
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Current treatments for obesity.

  2019cited by this paper
• Multi-Organs-on-Chips: Towards Long-Term Biomedical Investigations

  2019cited by this paper
• Microfluidic Chip with Integrated Electrophoretic Immunoassay for Investigating Cell-Cell Interactions.

  2018cited by this paper
• Recent advances in microfluidic technologies for cell-to-cell interaction studies.

  2018cited by this paper
• Establishment and characterization of a primary murine adipose tissue‐chip

  2018cited by this paper
• Trends in Obesity and Risk of Cardiovascular Disease

  2018cited by this paper
• Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies

  2018cited by this paper
• Osteocalcin improves insulin resistance and inflammation in obese mice: Participation of white adipose tissue and bone.

  2017cited by this paper
• PGBR extract ameliorates TNF‐α induced insulin resistance in hepatocytes

  2017cited by this paper
• Economic Burden of Obesity: A Systematic Literature Review

  2017cited by this paper
• WAT-on-a-chip: a physiologically relevant microfluidic system incorporating white adipose tissue.

  2017cited by this paper
• Adipocyte-Macrophage Cross-Talk in Obesity.

  2017cited by this paper
• Human adipocyte differentiation and characterization in a perfusion-based cell culture device

  2017cited by this paper
• Microfluidic systems for studying dynamic function of adipocytes and adipose tissue

  2017cited by this paper
• Organ/body-on-a-chip based on microfluidic technology for drug discovery.

  2017cited by this paper
• A novel IRS-1-associated protein, DGKζ regulates GLUT4 translocation in 3T3-L1 adipocytes

  2016cited by this paper
• Experimental Diabetes Mellitus in Different Animal Models

  2016cited by this paper
• Adipocyte lipolysis and insulin resistance.

  2016cited by this paper
• Long-term maintenance of a microfluidic 3D human liver sinusoid.

  2016cited by this paper
• Adipose tissue macrophages: going off track during obesity

  2016cited by this paper
• A microfluidic interface for the culture and sampling of adiponectin from primary adipocytes.

  2015cited by this paper
• Selective Insulin Resistance in Adipocytes*

  2015cited by this paper
• Characterization of Dedifferentiating Human Mature Adipocytes from the Visceral and Subcutaneous Fat Compartments: Fibroblast-Activation Protein Alpha and Dipeptidyl Peptidase 4 as Major Components of Matrix Remodeling

  2015cited by this paper
• Long term perfusion system supporting adipogenesis.

  2015cited by this paper
• High Temporal Resolution Detection of Patient-Specific Glucose Uptake from Human ex Vivo Adipose Tissue On-Chip.

  2015cited by this paper
• On-chip three-dimensional cell culture in phaseguides improves hepatocyte functions in vitro.

  2015cited by this paper
• Isolation and differentiation of stromal vascular cells to beige/brite cells.

  2013cited by this paper
• Cell culture purity issues and DFAT cells.

  2013cited by this paper
• On being the right size: scaling effects in designing a human-on-a-chip.

  2013cited by this paper
• Obesity and severe obesity forecasts through 2030.

  2012cited by this paper
• The use of animal models in diabetes research

  2012cited by this paper
• Hyperinsulinemia leads to uncoupled insulin regulation of the GLUT4 glucose transporter and the FoxO1 transcription factor

  2011cited by this paper
• Dedifferentiated fat cells: an alternative source of adult multipotent cells from the adipose tissues

  2011cited by this paper
• From 3D cell culture to organs-on-chips.

  2011cited by this paper
• Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents

  2011cited by this paper
• Ceiling culture-derived proliferative adipocytes retain high adipogenic potential suitable for use as a vehicle for gene transduction therapy.

  2011cited by this paper
• Insulin Regulates Adipocyte Lipolysis via an Akt-Independent Signaling Pathway

  2010cited by this paper
• Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence

  2010cited by this paper
• Rosiglitazone increases cell surface GLUT4 levels in 3T3-L1 adipocytes through an enhancement of endosomal recycling.

  2010cited by this paper
• TYPE 2 DIABETES MELLITUS: Etiology, Pathogenesis, and Natural History

  2010cited by this paper
• Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

  2010cited by this paper
• Dissecting the Mechanism of Insulin Resistance Using a Novel Heterodimerization Strategy to Activate Akt*

  2009cited by this paper
• TNF-alpha and adipocyte biology.

  2008cited by this paper
• A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

  2008cited by this paper
• IRS1-independent defects define major nodes of insulin resistance.

  2008cited by this paper
• Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

  2008cited by this paper
• TNF‐α and adipocyte biology

  2008cited by this paper
• Mechanisms of obesity-associated insulin resistance: many choices on the menu.

  2007cited by this paper
• Tumour necrosis factor‐α in human adipose tissue – from signalling mechanisms to clinical implications

  2007cited by this paper
• Mechanisms linking obesity to insulin resistance and type 2 diabetes

  2006cited by this paper
• Insulin signaling in human visceral and subcutaneous adipose tissue in vivo.

  2006cited by this paper
• Effects of metformin and rosiglitazone treatment on insulin signaling and glucose uptake in patients with newly diagnosed type 2 diabetes: a randomized controlled study.

  2005cited by this paper
• JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes*

  2005cited by this paper
• Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice.

  2005cited by this paper
• Stimulation of lipolysis by tumor necrosis factor-alpha in 3T3-L1 adipocytes is glucose dependent: implications for long-term regulation of lipolysis.

  2004cited by this paper
• Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARgamma), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo.

  2004cited by this paper
• Rosiglitazone ameliorates insulin resistance in brown adipocytes of Wistar rats by impairing TNF-α induction of p38 and p42/p44 mitogen-activated protein kinases

  2004cited by this paper
• Obesity-induced inflammatory changes in adipose tissue.

  2003cited by this paper
• Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

  2003cited by this paper
• Tissue-specific Ablation of the GLUT4 Glucose Transporter or the Insulin Receptor Challenges Assumptions about Insulin Action and Glucose Homeostasis*

  2003cited by this paper
• Interleukin-6 (IL-6) Induces Insulin Resistance in 3T3-L1 Adipocytes and Is, Like IL-8 and Tumor Necrosis Factor-α, Overexpressed in Human Fat Cells from Insulin-resistant Subjects*

  2003cited by this paper
• A PPAR agonist improves TNF-alpha-induced insulin resistance of adipose tissue in mice.

  2003cited by this paper
• A PPAR agonist improves TNF-α-induced insulin resistance of adipose tissue in mice

  2003cited by this paper
• Prototyping of microfluidic devices in poly(dimethylsiloxane) using solid-object printing.

  2002cited by this paper
• Role of Akt/protein kinase B in metabolism.

  2002cited by this paper
• Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory.

  2002cited by this paper
• Tumor necrosis factor-α suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: Nuclear factor-κB activation by TNF-α is obligatory

  2002cited by this paper
• Relationship between serum tumor necrosis factor-alpha and insulin resistance in obese men with Type 2 diabetes mellitus.

  2001cited by this paper
• Relationship between serum tumor necrosis factor-α and insulin resistance in obese men with Type 2 diabetes mellitus

  2001cited by this paper
• Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review.

  2000cited by this paper
• Dexamethasone-induced insulin resistance in 3T3-L1 adipocytes is due to inhibition of glucose transport rather than insulin signal transduction.

  2000cited by this paper
• Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.

  2000cited by this paper
• The Role of TNF-α in Human Adipose Tissue: Prevention of Weight Gain at the Expense of Insulin Resistance?

  1999cited by this paper
• Development of Insulin Resistance in 3T3-L1 Adipocytes*

  1997cited by this paper
• Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells.

  1997cited by this paper
• IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance

  1996cited by this paper
• Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation*

  1996cited by this paper
• Tumor necrosis factor alpha inhibits signaling from the insulin receptor.

  1994cited by this paper
• Kinetics of insulin action on protein synthesis in isolated adipocytes. Ability of glucose to selectively desensitize the glucose transport system without altering insulin stimulation of protein synthesis.

  1989cited by this paper
• Mechanism for enhanced glucose transport response to insulin in adipose cells from chronically hyperinsulinemic rats. Increased translocation of glucose transporters from an enlarged intracellular pool.

  1987cited by this paper
• Proliferation of unilocular fat cells in the primary culture.

  1987cited by this paper
• Primary cultures of unilocular fat cells: characteristics of growth in vitro and changes in differentiation properties.

  1986cited by this paper
• Studies on Human Adipose Cells in Culture: Relation of Cell Size and Cell Multiplication to Donor Age

  1975cited by this paper
• Antilipolytic effect of insulin in isolated fat cells of the rat.

  1966cited by this paper
• On Diabetes: Insulin Resistance Cellular Mechanisms of Insulin Resistance

  year unknowncited by this paper
• Interleukin-1 (cid:1) -Induced Insulin Resistance in Adipocytes through Down-Regulation of Insulin Receptor Substrate-1 Expression

  year unknowncited by this paper

• In Vitro Modeling of Interorgan Crosstalk: Multi-Organ-on-a-Chip for Studying Cardiovascular-Kidney-Metabolic Syndrome

  2025cites this paper
• Optimization and validation of a fat-on-a-chip model for non-invasive therapeutic drug discovery

  2024cites this paper
• Engineered adipose tissue platforms: recent breakthroughs and future perspectives

  2023cites this paper
• Animal Models in Diabetic Research—History, Presence, and Future Perspectives

  2023cites this paper
• A physiological adipose-on-chip disease model to mimic adipocyte hypertrophy and inflammation in obesity

  2022cites this paper
• Patient-derived pancreatic cancer-on-a-chip recapitulates the tumor microenvironment

  2022cites this paper
• Microfluidic cell-chip for an in vitro hepatic disease model

  2021cites this paper
• Autologous Human Immunocompetent White Adipose Tissue‐on‐Chip

  2021cites this paper
• Investigation of insulin resistance through a multiorgan microfluidic organ-on-chip

  2021cites this paper
• Effects of Bergamot Polyphenols on Mitochondrial Dysfunction and Sarcoplasmic Reticulum Stress in Diabetic Cardiomyopathy

  2021cites this paper