Environmental Influences and Polycystic Ovarian Syndrome

Polycystic ovarian syndrome (PCOS) is a complex endocrine-metabolic disorder whose pathogenesis is not well-understood. While genetic insults have been hypothesized as possible causes, there are a large number of environmental chemicals known to have detrimental effects on the endocrine system and may be irreversible, especially when exposure occurs early in development. Many of these chemicals have been investigated as causes of PCOS by measuring serum and urinary levels of common endocrine disruptors in women and adolescents with PCOS as well as using animal models for PCOS induction with chemical exposures.

• Publication year

  2020

• Venue

  Clinical obstetrics and gynecology

• Publication date

  2020-07-21

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.1097/GRF.0000000000000562PMID 32701518
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Experimental models of polycystic ovary syndrome: An update.

  2019cited by this paper
• Exposure to a Healthy Gut Microbiome Protects Against Reproductive and Metabolic Dysregulation in a PCOS Mouse Model

  2018cited by this paper
• Physiological Aspects of Female Fertility: Role of the Environment, Modern Lifestyle, and Genetics.

  2016cited by this paper
• Association of serum levels of typical organic pollutants with polycystic ovary syndrome (PCOS): a case-control study.

  2015cited by this paper
• The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls

  2015cited by this paper
• Transcriptional repression of the Ahr gene by LHCGR signaling in preovulatory granulosa cells is controlled by chromatin accessibility.

  2014cited by this paper
• Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol a in polycystic ovary syndrome: a case–control study

  2014cited by this paper
• Polychlorinated biphenyls.

  2011cited by this paper
• Neonatal Exposure to Bisphenol A and Reproductive and Endocrine Alterations Resembling the Polycystic Ovarian Syndrome in Adult Rats

  2010cited by this paper
• Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. a review. b_antizar@hotmail.com.

  2008cited by this paper
• Effect of bisphenol A on steroid hormone production in rat ovarian theca-interstitial and granulosa cells.

  2008cited by this paper
• In vitro molecular mechanisms of bisphenol A action.

  2007cited by this paper
• Positive relationship between androgen and the endocrine disruptor, bisphenol A, in normal women and women with ovarian dysfunction.

  2004cited by this paper
• Polychlorinated Biphenyls

  2002cited by this paper
• Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells.

  2002cited by this paper
• Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals

  2001cited by this paper

• Exploring GnRH pulsatility in PCOS and the role of GLP-1 as a targeted therapeutic approach

  2025cites this paper
• A review on critical appraisal and pathogenesis of polycystic ovarian syndrome

  2024cites this paper
• Endocrine Disruption of the Follicle-Stimulating Hormone Receptor Signaling During the Human Antral Follicle Growth

  2021cites this paper