The ubiquitin-proteasome system in glioma cell cycle control

A major determinant of cell fate is regulation of cell cycle. Tight regulation of this process is lost during the course of development and progression of various tumors. The ubiquitin-proteasome system (UPS) constitutes a universal protein degradation pathway, essential for the consistent recycling of a plethora of proteins with distinct structural and functional roles within the cell, including cell cycle regulation. High grade tumors, such as glioblastomas have an inherent potential of escaping cell cycle control mechanisms and are often refractory to conventional treatment. Here, we review the association of UPS with several UPS-targeted proteins and pathways involved in regulation of the cell cycle in malignant gliomas, and discuss the potential role of UPS inhibitors in reinstitution of cell cycle control.

• Publication year

  2012

• Venue

  Cell Division

• Publication date

  2012-07-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1186/1747-1028-7-18PMID 22817864PMCID 3462126
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The ubiquitin-proteasome system in glioma cell cycle control

  2012cited by this paper
• Parkin pathway activation mitigates glioma cell proliferation and predicts patient survival.

  2012cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• The GAS41-PP2Cβ Complex Dephosphorylates p53 at Serine 366 and Regulates Its Stability*

  2011cited by this paper
• Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo

  2011cited by this paper
• Somatic mutations of the Parkinson's disease–associated gene PARK2 in glioblastoma and other human malignancies

  2010cited by this paper
• Celastrol causes apoptosis and cell cycle arrest in rat glioma cells

  2010cited by this paper
• The familial Parkinson Disease gene PARK2 is a multisite tumor suppressor on chromosome 6q25.2-27 that regulates cyclin E

  2010cited by this paper
• Inhibition of gliomagenesis and attenuation of mitotic transition by MIIP

  2010cited by this paper
• ROC1/RBX1 E3 ubiquitin ligase silencing suppresses tumor cell growth via sequential induction of G2-M arrest, apoptosis, and senescence.

  2009influential reference
• z-Leucinyl-Leucinyl-Norleucinal Induces Apoptosis of Human Glioblastoma Tumor–Initiating Cells by Proteasome Inhibition and Mitotic Arrest Response

  2009cited by this paper
• SC68896, a Novel Small Molecule Proteasome Inhibitor, Exerts Antiglioma Activity In vitro and In vivo

  2009cited by this paper
• Myc down‐regulation affects cyclin D1/cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line

  2009cited by this paper
• Δ9-Tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells

  2008cited by this paper
• DNA-dependent protein kinase catalytic subunit modulates the stability of c-Myc oncoprotein

  2008cited by this paper
• An acidic environment changes cyclin D1 localization and alters colony forming ability in gliomas

  2008cited by this paper
• Malignant gliomas in adults.

  2008cited by this paper
• APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase.

  2007cited by this paper
• p21Waf1/Cip1/Sdi1 mediates retinoblastoma protein degradation

  2007cited by this paper
• Geldanamycin induces G2 arrest in U87MG glioblastoma cells through downregulation of Cdc2 and cyclin B1.

  2007cited by this paper
• Genetic pathways to primary and secondary glioblastoma.

  2007cited by this paper
• p27 degradation by an ellipticinium series of compound via ubiquitin-proteasome pathway

  2007cited by this paper
• Tumorigenesis and Neoplastic Progression Oncogenic Regulators and Substrates of the Anaphase Promoting Complex / Cyclosome Are Frequently Overexpressed in Malignant Tumors

  2007cited by this paper
• p21 (CDKN1A) is a Negative Regulator of p53 Stability

  2007cited by this paper
• Targeting Retinoblastoma Protein for Degradation by Proteasomes

  2006cited by this paper
• Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

  2006cited by this paper
• Malignant glioma: Neuropathology and Neurobiology

  2006cited by this paper
• Geldanamycin-induced degradation of Chk1 is mediated by proteasome.

  2005cited by this paper
• Ubiquitination‐resistant p53 protein transduction therapy facilitates anti‐cancer effect on the growth of human malignant glioma cells

  2005cited by this paper
• Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM)

  2005cited by this paper
• IkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylation.

  2005cited by this paper
• The ubiquitin-proteasome pathway and its role in cancer.

  2005cited by this paper
• IκB Kinase α Regulates Subcellular Distribution and Turnover of Cyclin D1 by Phosphorylation*

  2005cited by this paper
• Merlin Neutralizes the Inhibitory Effect of Mdm2 on p53*

  2004cited by this paper
• Proteasome-Mediated Destruction of the Cyclin A/Cyclin-Dependent Kinase 2 Complex Suppresses Tumor Cell Growth in Vitro and in Vivo

  2004cited by this paper
• Regulating the p53 system through ubiquitination

  2004cited by this paper
• Apoptosis in gliomas: molecular mechanisms and therapeutic implications.

  2004cited by this paper
• Effects of the proteasome inhibitor ritonavir on glioma growth in vitro and in vivo.

  2004cited by this paper
• The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications.

  2004cited by this paper
• The proteasome: structure, function, and role in the cell.

  2003cited by this paper
• The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network.

  2002cited by this paper
• Inverse relationship between p27/Kip.1 and the F-box protein Skp2 in human astrocytic gliomas by immunohistochemistry and Western blot.

  2002cited by this paper
• Pescadillo, a Novel Cell Cycle Regulatory Protein Abnormally Expressed in Malignant Cells*

  2001cited by this paper
• Ubiquitin‐mediated proteolysis: biological regulation via destruction

  2000cited by this paper
• Proteasome-dependent degradation of p27/kip1 in gliomas.

  1999cited by this paper
• Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.

  1999cited by this paper
• Expression of alternatively spliced mdm2 transcripts correlates with stabilized wild‐type p53 protein in human glioblastoma cells

  1999cited by this paper
• Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein.

  1997cited by this paper

• Unveiling Prognostic Hub Genes for the Management of Gliomagenesis through Transcriptome Profiling

  2026cites this paper
• Proteasome Inhibitors against Glioblastoma—Overview of Molecular Mechanisms of Cytotoxicity, Progress in Clinical Trials, and Perspective for Use in Personalized Medicine

  2023cites this paper
• Therapeutic Options in Neuro-Oncology

  2022cites this paper
• Ubiquitin-Specific Protease 6 n-Terminal-like Protein (USP6NL) and the Epidermal Growth Factor Receptor (EGFR) Signaling Axis Regulates Ubiquitin-Mediated DNA Repair and Temozolomide-Resistance in Glioblastoma

  2022cites this paper
• Genes of the Ubiquitin Proteasome System Qualify as Differential Markers in Malignant Glioma of Astrocytic and Oligodendroglial Origin

  2022cites this paper
• MMP-1, UCH-L1, and 20S Proteasome as Potential Biomarkers Supporting the Diagnosis of Brain Glioma

  2022cites this paper
• Styryl-cinnamate hybrid inhibits glioma by alleviating translation, bioenergetics and other key cellular responses leading to apoptosis.

  2019cites this paper
• Predicting E3 Ubiquitin Ligases as Possible Promising Biomarkers for Brain Tumors

  2019cites this paper
• Proteasome mediated degradation of CDC25C and Cyclin B1 in Demethoxycurcumin treated human glioma U87 MG cells to trigger G2/M cell cycle arrest

  2018cites this paper
• Cdh1 degradation is mediated by APC/C-Cdh1 and SCF-Cdc4 in budding yeast.

  2018cites this paper
• The 4‐Celled Tetrabaena socialis Nuclear Genome Reveals the Essential Components for Genetic Control of Cell Number at the Origin of Multicellularity in the Volvocine Lineage

  2018cites this paper
• The ubiquitin-proteasome pathway in adult and pediatric brain tumors: biological insights and therapeutic opportunities

  2017cites this paper
• Chapter 5 – Multimodality Targeting of Glioma Cells

  2016cites this paper
• The Challenges and the Promise of Molecular Targeted Therapy in Malignant Gliomas1

  2015cites this paper
• Downregulation of ubiquitin-associated protein 2-like with a short hairpin RNA inhibits human glioma cell growth in vitro

  2015influential citation
• Knockdown of Pim-3 suppresses the tumorigenicity of glioblastoma by regulating cell cycle and apoptosis.

  2015cites this paper
• Immunohistochemical determination of wound age in mice

  2014cites this paper
• EBNA3C Augments Pim-1 Mediated Phosphorylation and Degradation of p21 to Promote B-Cell Proliferation

  2014cites this paper
• FRK suppresses the proliferation of human glioma cells by inhibiting cyclin D1 nuclear accumulation

  2014cites this paper
• Oncoprotein stabilization in brain tumors

  2014cites this paper
• Glioma-Associated Proteases

  2014cites this paper
• Farelerde immunohistokimyasal metodlarla yara yaşi tespiti

  2014cites this paper
• Novel Regulation of the Cell Cycle During Cell Fate Decisions in the Central Nervous System

  2013cites this paper
• Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury

  2013cites this paper