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A Native 51 kDa Leishmania Membrane Protein Revealed as a Novel Antigenic Candidate for Immuno-Diagnosis of Human VL and PKDL diseases

Mohd Kamran,Sarfaraz Ahmad Ejazi,Anirban Bhattacharyya,Nicky Didwania,N. Ali

Published 2020 in Journal of cellular immunology

ABSTRACT

Visceral leishmaniasis, a life threatening protozoan parasitic disease, is mainly caused by Leishmania donovani complex and is prevalent in the Indian subcontinent, East Africa and Brazil. VL patients even after successful treatment might show other clinical revelations of skin called post kala-azar dermal leishmaniasis (PKDL) [1]. Although there is substantial decline in the incidence of VL in some areas, the disease is still prevalent in most of the endemic regions with newer areas of infection being continuously reported [1]. Classical VL diagnosis relies on microscopic observation of the parasite from splenic and bone marrow aspirates [2,3]. For PKDL, slit-skin smear or biopsy specimens derived from skin lesions are examined for presence of the parasite [4,5]. These procedures Abstract

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