Transforming Growth Factor Beta Receptor 3 Haplotypes in Sickle Cell Disease Are Associated with Lipid Profile and Clinical Manifestations

Individuals with sickle cell disease (SCD) present both chronic and acute inflammatory events. The TGF-β pathway is known to play a role in immune response, angiogenesis, inflammation, hematopoiesis, vascular inflammation, and cell proliferation. Polymorphisms in the transforming growth factor-beta receptor 3 (TGFBR3) gene have been linked to several inflammatory diseases. This study investigated associations between two TGFBR3 haplotypes and classical laboratory parameters, as well as clinical manifestations, in SCD. We found that individuals with the GG haplotype presented higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, non-HDL cholesterol, total proteins, and globulin than individuals with non-GG haplotypes. In addition, the GG haplotype was associated with a previous history of pneumonia. Individuals with the CGG haplotype presented increased plateletcrit, TC, LDL-C levels, and non-HDL cholesterol. The CCG haplotype was also associated with a previous history of pneumonia. Our findings suggest that individuals with the GG and CGG haplotypes of TGFBR3 present important alterations in lipid profile.

• Publication year

  2020

• Venue

  Mediators of Inflammation

• Publication date

  2020-10-13

• Fields of study

  Medicine

• Identifiers
  DOI 10.1155/2020/3185015PMID 33149723PMCID 7603616
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sickle cell disease: A distinction of two most frequent genotypes (HbSS and HbSC)

  2020cited by this paper
• Higher values of triglycerides:HDL-cholesterol ratio hallmark disease severity in children and adolescents with sickle cell anemia

  2019cited by this paper
• Elevated circulating TGF-β is not the cause of increased atherosclerosis development in biglycan deficient mice.

  2018cited by this paper
• Betaglycan (TGFBR3) up-regulation correlates with increased TGF-β signaling in Marfan patient fibroblasts in vitro.

  2018cited by this paper
• Inflammatory mediators in sickle cell anaemia highlight the difference between steady state and crisis in paediatric patients

  2018cited by this paper
• Sickle Cell Anemia and Its Phenotypes.

  2018cited by this paper
• Sickle cell disease

  2018cited by this paper
• Acute chest syndrome in sickle cell anaemia: higher serum levels of interleukin-8 and highly sensitive C-reactive proteins are associated with impaired lung function

  2018cited by this paper
• Comparative study of sickle cell anemia and hemoglobin SC disease: clinical characterization, laboratory biomarkers and genetic profiles

  2017cited by this paper
• TRIGLYCERIDES, ATHEROSCLEROSIS, AND CARDIOVASCULAR OUTCOME STUDIES: FOCUS ON OMEGA-3 FATTY ACIDS.

  2017cited by this paper
• Heme-mediated cell activation: the inflammatory puzzle of sickle cell anemia

  2017cited by this paper
• Simvastatin reduces vaso‐occlusive pain in sickle cell anaemia: a pilot efficacy trial

  2017cited by this paper
• Alteration in transforming growth factor-β receptor expression in gallbladder disease: implications of chronic cholelithiasis and chronic Salmonella typhi infection

  2016cited by this paper
• Non-HDL-C is a Better Predictor for the Severity of Coronary Atherosclerosis Compared with LDL-C.

  2016cited by this paper
• TGF-β inhibitors stimulate red blood cell production by enhancing self-renewal of BFU-E erythroid progenitors.

  2016cited by this paper
• Cholelithiasis and its complications in sickle cell disease in a university hospital

  2016cited by this paper
• The Diagnostic Value of Serum C-Reactive Protein for Identifying Pneumonia in Hospitalized Patients with Acute Respiratory Symptoms

  2016cited by this paper
• Sickle red cells as danger signals on proinflammatory gene expression, leukotriene B4 and interleukin-1 beta production in peripheral blood mononuclear cell.

  2016cited by this paper
• Normal Non-HDL Cholesterol, Low Total Cholesterol, and HDL Cholesterol Levels in Sickle Cell Disease Patients in the Steady State: A Case-Control Study of Tema Metropolis

  2016cited by this paper
• The role of mitogen-activated protein kinases and sterol receptor coactivator-1 in TGF-β-regulated expression of genes implicated in macrophage cholesterol uptake

  2016cited by this paper
• A role for the accessory type III transforming growth factor β receptor (Tgfbr3) in lung alveolarisation

  2016influential reference
• Cholesterol, inflammation and innate immunity

  2015cited by this paper
• Association of homocysteine and inflammatory-related molecules in sickle cell anemia

  2015cited by this paper
• Structural Modification of Plasma Albumin in Sickle Cell Anemia

  2014cited by this paper
• Association analysis of TGFBR3 gene with Behçet's disease and idiopathic intermediate uveitis in a Caucasian population

  2014cited by this paper
• Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice

  2014cited by this paper
• Dual role of TGFBR3 in bladder cancer.

  2013cited by this paper
• Polymorphisms in the potential functional regions of the TGF‐β 1 and TGF‐β receptor genes and disease susceptibility in HBV‐related hepatocellular carcinoma patients

  2012cited by this paper
• Genetic modifiers of sickle cell disease

  2012cited by this paper
• Effects of the Sickle Cell (S) Gene on Serum Protein Profile

  2012cited by this paper
• Anthropometric measures as predictors of cardiovascular disease risk factors in the urban population of Iran.

  2012cited by this paper
• Elevated creatinine is a sensitive severity marker in community acquired pneumonia

  2012cited by this paper
• Pulmonary complications of sickle cell disease.

  2012cited by this paper
• Association Analysis of TGFBR3 Gene with Vogt-Koyanagi-Harada Disease and Behcet’s Disease in the Chinese Han Population

  2012cited by this paper
• Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis.

  2012cited by this paper
• Genetic predictors for stroke in children with sickle cell anemia.

  2011cited by this paper
• Progress and challenges in translating the biology of atherosclerosis

  2011cited by this paper
• Biochemical Indicator of Sickle Cell Disease: Preliminary Report from India

  2011cited by this paper
• Acute care utilization and rehospitalizations for sickle cell disease.

  2010cited by this paper
• Lipid levels in sickle‐cell disease associated with haemolytic severity, vascular dysfunction and pulmonary hypertension

  2010cited by this paper
• Association between genetic variations of the transforming growth factor β receptor type III and asthma in a Korean population

  2010influential reference
• Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease

  2010cited by this paper
• Gastrointestinal and hepatic complications of sickle cell disease.

  2010cited by this paper
• Genomic polymorphisms in sickle cell disease: implications for clinical diversity and treatment

  2010cited by this paper
• Sequencing of TGF-beta pathway genes in familial cases of intracranial aneurysm.

  2009cited by this paper
• Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema.

  2009cited by this paper
• Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease.

  2008cited by this paper
• Medidas gerais no tratamento das doenças falciformes

  2007cited by this paper
• Genetic polymorphisms associated with priapism in sickle cell disease

  2007cited by this paper
• Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical subphenotypes.

  2007influential reference
• Association of Genetic Polymorphisms in the TGF-β Pathway with the Acute Chest Syndrome of Sickle Cell Anemia.

  2007cited by this paper
• Association of polymorphisms of IGF1R and genes in the transforming growth factor- beta /bone morphogenetic protein pathway with bacteremia in sickle cell anemia.

  2006cited by this paper
• Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGF‐β/BMP pathway

  2006cited by this paper
• Outcome of Sickle Cell Anemia: A 4-Decade Observational Study of 1056 Patients

  2005cited by this paper
• Haploview: analysis and visualization of LD and haplotype maps

  2005cited by this paper
• Association of klotho, bone morphogenic protein 6, and annexin A2 polymorphisms with sickle cell osteonecrosis.

  2005cited by this paper
• Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease.

  2005cited by this paper
• Joint distribution of non-HDL and LDL cholesterol and coronary heart disease risk prediction among individuals with and without diabetes.

  2005cited by this paper
• Metabolic syndrome.

  2005cited by this paper
• Transforming growth factor-β pathway is activated in cholecystolithiasis

  2005cited by this paper
• Genetic dissection and prognostic modeling of overt stroke in sickle cell anemia

  2005cited by this paper
• Transforming growth factor-beta pathway is activated in cholecystolithiasis.

  2005cited by this paper
• Metabolic Syndrome: Pathophysiology and Implications for Management of Cardiovascular Disease

  2002cited by this paper
• Functional Roles for the Cytoplasmic Domain of the Type III Transforming Growth Factor β Receptor in Regulating Transforming Growth Factor β Signaling*

  2001influential reference
• Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterol ratio as indices of ischemic heart disease risk in men: the Quebec Cardiovascular Study.

  2001cited by this paper
• Functional roles for the cytoplasmic domain of the type III transforming growth factor beta receptor in regulating transforming growth factor beta signaling.

  2001cited by this paper
• Causes and outcomes of the acute chest syndrome in sickle cell disease. National Acute Chest Syndrome Study Group.

  2000cited by this paper
• Causes and Outcomes of the Acute Chest Syndrome in Sickle Cell Disease

  2000cited by this paper
• Type 2 cytokine serum levels in healthy sickle cell disease patients.

  1997cited by this paper
• Acute chest syndrome in sickle cell disease: clinical presentation and course. Cooperative Study of Sickle Cell Disease.

  1997cited by this paper
• Serum total cholesterol and risk of hospitalization, and death from respiratory disease.

  1997cited by this paper
• Laboratory profile of sickle cell disease: a cross-sectional analysis. The Cooperative Study of Sickle Cell Disease.

  1992cited by this paper
• Gall stones in sickle cell disease in the United Kingdom.

  1987cited by this paper
• Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.

  1972cited by this paper

• The Association of Serum Level of TGF‐β1 and Clinical Manifestations in Sickle Cell Anemia: A Case‐Control Study

  2025cites this paper
• Nonlinear Relationship Between Triglyceride‐to‐High‐Density Lipoprotein Cholesterol Ratio and Non‐Alcoholic Fatty Liver Disease: A Secondary Retrospective Analysis Based on a Japanese Longitudinal Study

  2025cites this paper
• A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia

  2024cites this paper
• Genetic Variation and Sickle Cell Disease Severity

  2023cites this paper
• Does TGFBR3 Polymorphism Increase the Risk of Silent Cerebral Infarction in Egyptian Children with Sickle Cell Disease?

  2022cites this paper