Transmission of Clonal Hepatitis C Virus Genomes Reveals the Dominant but Transitory Role of CD8+ T Cells in Early Viral Evolution

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Journal of Virology

• Publication date

  2011-09-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.02654-10PMID 21900166PMCID PMC3209267
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Constrained Pattern of Viral Evolution in Acute and Early HCV Infection Limits Viral Plasticity

  2011influential reference
• Adaptive immunity to the hepatitis C virus.

  2010cited by this paper
• Selection‐driven immune escape is not a significant factor in the failure of CD4 T cell responses in persistent hepatitis C virus infection

  2010cited by this paper
• Virological footprint of CD4+ T-cell responses during chronic hepatitis C virus infection

  2010cited by this paper
• Acceleration of Hepatitis C Virus Envelope Evolution in Humans Is Consistent with Progressive Humoral Immune Selection during the Transition from Acute to Chronic Infection

  2010cited by this paper
• Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus.

  2009cited by this paper
• Impact of viral selected mutations on T cell mediated immunity in chronically evolving and self limiting acute HCV infection.

  2009cited by this paper
• Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response.

  2009cited by this paper
• Adaptive Immunity to Hepatitis C Virus

  2009cited by this paper
• Transmission and Long-Term Stability of Compensated CD8 Escape Mutations

  2008cited by this paper
• Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness

  2008cited by this paper
• Previously Infected Chimpanzees Are Not Consistently Protected against Reinfection or Persistent Infection after Reexposure to the Identical Hepatitis C Virus Strain

  2008cited by this paper
• Molecular Evolution and Phylogenetics

  2008cited by this paper
• Escape from HLA-B*08-Restricted CD8 T Cells by Hepatitis C Virus Is Associated with Fitness Costs

  2008cited by this paper
• Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo.

  2007cited by this paper
• Monitoring of Hepatitis C Virus Quasispecies in Chronic Infection by Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry Mutation Detection

  2007cited by this paper
• Viral Sequence Evolution in Acute Hepatitis C Virus Infection

  2007influential reference
• Human leukocyte antigen–associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution

  2007cited by this paper
• Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B*5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection

  2007cited by this paper
• Evidence of Viral Adaptation to HLA Class I-Restricted Immune Pressure in Chronic Hepatitis C Virus Infection

  2006cited by this paper
• euHCVdb: the European hepatitis C virus database

  2006cited by this paper
• Maintenance of viral suppression in HIV-1–infected HLA-B*57+ elite suppressors despite CTL escape mutations

  2006cited by this paper
• Unbiased estimation of the rates of synonymous and nonsynonymous substitution

  2006cited by this paper
• Positive selection of cytotoxic T lymphocyte escape variants during acute hepatitis C virus infection

  2005cited by this paper
• Relation between viral fitness and immune escape within the hepatitis C virus protease

  2005cited by this paper
• The European Hepatitis C Virus database

  2005cited by this paper
• Divergent and convergent evolution after a common-source outbreak of hepatitis C virus

  2005cited by this paper
• HIV-1 Viral Escape in Infancy Followed by Emergence of a Variant-Specific CTL Response1

  2005cited by this paper
• Mutational escape from CD8+ T cell immunity

  2005cited by this paper
• Selective Escape from CD8+ T-Cell Responses Represents a Major Driving Force of Human Immunodeficiency Virus Type 1 (HIV-1) Sequence Diversity and Reveals Constraints on HIV-1 Evolution

  2005cited by this paper
• Evidence for cross-genotype neutralization of hepatitis C virus pseudo-particles and enhancement of infectivity by apolipoprotein C1.

  2005cited by this paper
• Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C

  2005cited by this paper
• Immune evasion versus recovery after acute hepatitis C virus infection from a shared source

  2005cited by this paper
• Cellular immune selection with hepatitis C virus persistence in humans

  2005influential reference
• Genetic diversity and evolution of hepatitis C virus--15 years on.

  2004cited by this paper
• CD8 Epitope Escape and Reversion in Acute HCV Infection

  2004cited by this paper
• Long-Term Persistence of Infection in Chimpanzees Inoculated with an Infectious Hepatitis C Virus Clone Is Associated with a Decrease in the Viral Amino Acid Substitution Rate and Low Levels of Heterogeneity

  2004influential reference
• Extraepitopic Compensatory Substitutions Partially Restore Fitness to Simian Immunodeficiency Virus Variants That Escape from an Immunodominant Cytotoxic-T-Lymphocyte Response

  2004cited by this paper
• A Dominant Role for CD8+-T-Lymphocyte Selection in Simian Immunodeficiency Virus Sequence Variation

  2004cited by this paper
• Evolution of hepatitis C virus in blood donors and their respective recipients.

  2003cited by this paper
• Simian-Human Immunodeficiency Virus Escape from Cytotoxic T-Lymphocyte Recognition at a Structurally Constrained Epitope

  2003cited by this paper
• Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees

  2002cited by this paper
• Cellular immune responses against hepatitis C virus: the evidence base 2002

  2002cited by this paper
• The outcome of hepatitis C virus infection is predicted by escape mutations in epitopes targeted by cytotoxic T lymphocytes.

  2001influential reference
• Identification of Five Different Patr Class I Molecules That Bind HLA Supertype Peptides and Definition of Their Peptide Binding Motifs1

  2000cited by this paper
• Hypervariable Region 1 Sequence Stability during Hepatitis C Virus Replication in Chimpanzees

  2000cited by this paper
• Estimating synonymous and nonsynonymous substitution rates under realistic evolutionary models.

  2000cited by this paper
• Hepatitis C virus: an infectious molecular clone of a second major genotype (2a) and lack of viability of intertypic 1a and 2a chimeras.

  1999cited by this paper
• Viral Persistence, Antibody to E1 and E2, and Hypervariable Region 1 Sequence Stability in Hepatitis C Virus-Inoculated Chimpanzees

  1999cited by this paper
• Analysis of a successful immune response against hepatitis C virus.

  1999cited by this paper
• Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon-alpha therapy.

  1998cited by this paper
• Hepatitis C Viral Dynamics in Vivo and the Antiviral Efficacy of Interferon-α Therapy

  1998cited by this paper
• Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.

  1997influential reference
• Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee.

  1997cited by this paper
• Transmission of hepatitis C by intrahepatic inoculation with transcribed RNA.

  1997cited by this paper
• Escape of human immunodeficiency virus from immune control.

  1997cited by this paper
• Comparison of Class I MHC Alleles in Humans and Apes

  1990cited by this paper
• Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions.

  1986cited by this paper

• Update on Hepatitis C Vaccine: Results and Challenges

  2024cites this paper
• Mechanisms and Consequences of Genetic Variation in Hepatitis C Virus (HCV).

  2023cites this paper
• T-Cell Immunity against the Hepatitis C Virus: A Persistent Research Priority in an Era of Highly Effective Therapy.

  2020cites this paper
• Viral Escape Mechanisms in Hepatitis C and the Clinical Consequences of Persistent Infection

  2020cites this paper
• Hepatitis C Virus Genetic Variability, Human Immune Response, and Genome Polymorphisms: Which Is the Interplay?

  2019cites this paper
• Association of HLA‐DQB1*03:01 and DRB1*11:01 with spontaneous clearance of hepatitis C virus in Chinese Li ethnicity, an ethnic group genetically distinct from Chinese Han ethnicity and infected with unique HCV subtype

  2019cites this paper
• HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen

  2019cites this paper
• Increase in the genetic polymorphism of varicella-zoster virus after passaging in in vitro cell culture

  2019cites this paper
• Current status and future development of infectious cell‐culture models for the major genotypes of hepatitis C virus: Essential tools in testing of antivirals and emerging vaccine strategies

  2018cites this paper
• Broadening CD4+ and CD8+ T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes

  2017cites this paper
• Innate and Adaptive Immune Responses in Chronic HCV Infection.

  2017cites this paper
• Studying Within-Host Viral Evolution Using Pooled Next-Generation Sequencing Data

  2016cites this paper
• The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control.

  2016cites this paper
• Persistent hepatitis C viral replication despite priming of functional CD8+ T cells by combined therapy with a vaccine and a direct‐acting antiviral

  2015cites this paper
• T cell responses in hepatitis C virus infection: historical overview and goals for future research.

  2015cites this paper
• Molecular characterization of the transmission and early diversification of hepatitis C virus

  2015influential citation
• Transmitted/Founder Viruses Rapidly Escape from CD8+ T Cell Responses in Acute Hepatitis C Virus Infection

  2015cites this paper
• Within-host nucleotide diversity of virus populations: insights from next-generation sequencing.

  2015cites this paper
• Functionally conserved architecture of hepatitis C virus RNA genomes

  2015cites this paper
• Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design

  2015cites this paper
• Evolution of a Cell Culture-Derived Genotype 1a Hepatitis C Virus (H77S.2) during Persistent Infection with Chronic Hepatitis in a Chimpanzee

  2014influential citation
• Mutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infections

  2014cites this paper
• T‐cell immunity and hepatitis C virus reinfection after cure of chronic hepatitis C with an interferon‐free antiviral regimen in a chimpanzee

  2014influential citation
• CD8+ T-Cell Responses in Acute Hepatitis C Virus Infection

  2014cites this paper
• CD8 C T-cell responses in acute hepatitis C virus infection

  2014cites this paper
• Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses

  2013cites this paper
• Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells

  2013cites this paper
• Systems biology analyses to define host responses to HCV infection and therapy.

  2013cites this paper
• Between Scylla and Charybdis: the role of the human immune system in the pathogenesis of hepatitis C.

  2013cites this paper
• Animal Models of Hepatitis C Virus Infection

  2013cites this paper
• Analysis of diversity of hepatitis C virus glycoproteins E1 and E2

  2012cites this paper
• Generation of polyfunctional T cells against HCV by T cell redirection and vaccination

  2012cites this paper
• Animal models for the study of hepatitis C virus infection and related liver disease.

  2012cites this paper