+17 C/G polymorphism in matrix metalloproteinase (MMP)-8 gene and its association with periodontitis

Introduction: Matrix metalloproteinase-8 (MMP-8), encoded by MMP-8 gene (chromosomal location, 11q22.3), is a proteolytic enzyme that is involved in the pathogenesis of periodontitis. Polymorphism of the encoding MMP-8 gene can affect the risk of the disease. Objectives: This study aimed to evaluate the relationship between +17 C/G polymorphism in MMP-8 and periodontitis in an Indonesian sample population. Material and methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of the +17 C/G polymorphism in MMP-8 was conducted in stored genomic DNA samples from 100 subjects with periodontitis and 100 healthy controls. Patients were examined in a previous study by a periodontics and diagnosed as periodontitis based on anamnesis and clinical examination (periodontal pocket depth ≥ 4 mm and the presence of clinical attachment loss. Results: The frequencies of the genotypes or alleles in the periodontitis and control groups were not significant-ly different (genotype, p = 0.283; alleles, p = 0.11). Any remaining trend toward higher frequencies of the polymorphic genotypes or alleles in the periodontitis group was explained by the adjustment for age. Conclusions: The results showed no significant association between the +17 C/G polymorphism in MMP-8 and the risk of periodontitis in the Indonesian population. No change in the significance is expected even with a considerably larger sample.

• Publication year

  2020

• Venue

  Journal of Stomatology

• Publication date

  2020-08-30

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.5114/jos.2020.98310
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

  2018cited by this paper
• Association of interleukin 8 -251 A/T gene polymorphism with periodontitis in Indonesia

  2018influential reference
• POLYMORPHISM OF METHYLENETETRAHYDROFOLATE REDUCTASE (A1298C) AS A RISK FACTOR FOR OSTEOPOROSIS IN POST-MENOPAUSAL INDONESIAN WOMEN

  2017influential reference
• Personalized medicine: an update of salivary biomarkers for periodontal diseases.

  2016cited by this paper
• Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases.

  2016cited by this paper
• The association between subgingival periodontal pathogens and systemic inflammation.

  2015cited by this paper
• A Genome-wide Association Study of Periodontitis in a Japanese Population

  2015cited by this paper
• Genomewide association study on chronic periodontitis in Korean population: results from the Yangpyeong health cohort.

  2015cited by this paper
• Matrix metalloproteinase (MMP)-8 and tissue inhibitor of MMP-1 (TIMP-1) gene polymorphisms in generalized aggressive periodontitis: gingival crevicular fluid MMP-8 and TIMP-1 levels and outcome of periodontal therapy.

  2014influential reference
• Java Project on Periodontal Diseases: Causes of tooth loss in a cohort of untreated individuals

  2014cited by this paper
• Genome-wide association study of chronic periodontitis in a general German population.

  2013cited by this paper
• Genetic susceptibility to periodontitis

  2012cited by this paper
• Human matrix metalloproteinases: an ubiquitarian class of enzymes involved in several pathological processes.

  2012cited by this paper
• Matrix metalloproteinase 8 (MMP8) gene polymorphisms in chronic periodontitis.

  2012cited by this paper
• Genome-wide Association Study of Periodontal Pathogen Colonization

  2012cited by this paper
• MMP-8 -799 C>T genetic polymorphism is associated with the susceptibility to chronic and aggressive periodontitis in Taiwanese.

  2011cited by this paper
• Association between genetic risk score and periodontitis onset and progression: a pilot study.

  2011cited by this paper
• IL-1β Genetic Polimorphism in Menopause Women as Periodontal Disease Risk Factor

  2011influential reference
• COX-2 Is Associated with Periodontitis in Europeans

  2010cited by this paper
• Prevalence and simultaneous occurrence of periodontitis and dental caries.

  2010cited by this paper
• Monitoring periodontal disease status in smokers and nonsmokers using a gingival crevicular fluid matrix metalloproteinase-8-specific chair-side test.

  2006influential reference
• The global burden of oral diseases and risks to oral health.

  2005cited by this paper
• Functionally significant SNP MMP8 promoter haplotypes and preterm premature rupture of membranes (PPROM).

  2004cited by this paper
• Genes and gene polymorphisms associated with periodontal disease.

  2003cited by this paper

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