Endothelial protein C receptor and protease-activated receptor-1 mediate induction of a wound-healing phenotype in human keratinocytes by activated protein C.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Investigative Dermatology

• Publication date

  2005-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/J.0022-202X.2005.23952.XPMID 16354200
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PAR1 Cleavage and Signaling in Response to Activated Protein C and Thrombin*

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• A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse.

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• Protease-activated Receptor-1 Signaling by Activated Protein C in Cytokine-perturbed Endothelial Cells Is Distinct from Thrombin Signaling*

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• Activated protein C prevents inflammation yet stimulates angiogenesis to promote cutaneous wound healing

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• Prediction and validation of the distinct dynamics of transient and sustained ERK activation

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• Structure and functions of the endothelial cell protein C receptor.

  2004influential reference
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• Activated Protein C Induces Endothelial Cell Proliferation by Mitogen-Activated Protein Kinase Activation In Vitro and Angiogenesis In Vivo

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• Activated protein C prevents neuronal apoptosis via protease activated receptors 1 and 3.

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• Activated protein C stimulates proliferation, migration and wound closure, inhibits apoptosis and upregulates MMP-2 activity in cultured human keratinocytes.

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• Leukocyte and endothelial cell interactions in sepsis: Relevance of the protein C pathway

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• Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C.

  2003cited by this paper
• Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.

  2003cited by this paper
• Activated protein C signals through the thrombin receptor PAR1 in endothelial cells

  2003cited by this paper
• PARticipation in inflammation.

  2003cited by this paper
• Expression and function of the endothelial protein C receptor in human neutrophils.

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• Such stuff as dreams are made on: mediator-directed therapy in sepsis

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• Activated Protein C Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production by Inhibiting Activation of both Nuclear Factor-κB and Activator Protein-1 in Human Monocytes

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• Activated protein C: potential therapy for severe sepsis, thrombosis, and stroke.

  2002cited by this paper
• Molecular interpretation of ERK signal duration by immediate early gene products

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• Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway

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• The Crystal Structure of the Endothelial Protein C Receptor and a Bound Phospholipid*

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• Calcium- and vitamin D-regulated keratinocyte differentiation.

  2001cited by this paper
• Protease-activated receptors in inflammation, neuronal signaling and pain.

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• Characterization of protein C receptor expression in monocytes

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• Protease-activated receptor-1 stimulates Ca2+-dependent Cl− secretion in human intestinal epithelial cells

  2001cited by this paper
• Protease-activated receptor-1 stimulates Ca(2+)-dependent Cl(-) secretion in human intestinal epithelial cells.

  2001cited by this paper
• Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.

  2000cited by this paper
• Distribution and potential biologic function of the thrombin receptor PAR-1 on human keratinocytes

  2000cited by this paper
• Activated Protein C Directly Activates Human Endothelial Gelatinase A*

  2000cited by this paper
• The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis.

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• Protease-Activated Receptors and Platelet Function

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• Lipid antigen presentation in the immune system; lessons learned from CD 1 d knockout mice

  1999cited by this paper
• Structural prediction and analysis of endothelial cell protein C/activated protein C receptor.

  1999cited by this paper
• Matrix metalloproteinase 2 (gelatinase A) is related to migration of keratinocytes.

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• The molecular basis of CD 1 ‐mediated presentation of Iipid antigens

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• Reconstitution of the Human Endothelial Cell Protein C Receptor with Thrombomodulin in Phosphatidylcholine Vesicles Enhances Protein C Activation*

  1999cited by this paper
• Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3.

  1998cited by this paper
• Activation Mechanism of Anticoagulant Protein C in Large Blood Vessels Involving the Endothelial Cell Protein C Receptor

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• Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway.

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  1997cited by this paper
• Matrix metalloproteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyzes the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4- and 1/4-length fragments.

  1995cited by this paper
• Matrix Metalloproteinase-2 Is an Interstitial Collagenase

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• Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor.

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• Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts. Purification and activation of the precursor and enzymic properties.

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• Substructure of keratohyalin granules of the epidermis as revealed by high resolution electron microscopy.

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• Endothelial Protein C Receptor and Its Impact on Rheumatic Disease

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• The APC-EPCR-PAR1 axis in sickle cell disease

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• Activated Protein C Protects against Murine Contact Dermatitis by Suppressing Protease-Activated Receptor 2

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• Identification of a broad lipid repertoire associated to the endothelial cell protein C receptor (EPCR)

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• Protease-Activated Receptors in Health and Disease.

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• "Activated Protein C (APC) Promotes A Healing Phenotype in Cultured Murine Tenocytes Via Protease- Activated Receptor (PAR)-2, but not PAR-1"

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• Novel positive allosteric modulator of protease‐activated receptor 1 promotes skin wound healing in hairless mice

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• Therapeutic values of chick early amniotic fluid (ceAF) that facilitates wound healing via potentiating a SASP-mediated transient senescence

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• Sex-dependent effects of genetic upregulation of activated protein C on delayed effects of acute radiation exposure in the mouse heart, small intestine, and skin

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• Innate Lymphocyte Mechanisms in Skin Diseases.

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• Transient Senescence Induces Wound Healing Through SASP Factors: Therapeutic Potentials of Chick Early Amniotic Fluid (ceAF)

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• Contribution of platelets, the coagulation and fibrinolytic systems to cutaneous wound healing.

  2019cites this paper
• Endothelial Protein C Receptor (EPCR), Protease Activated Receptor-1 (PAR-1) and Their Interplay in Cancer Growth and Metastatic Dissemination

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• Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside

  2019cites this paper
• Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation.

  2018cites this paper
• Gut microbiota - architects of small intestinal capillaries.

  2018cites this paper
• The Immunoregulatory Activities of Activated Protein C in Inflammatory Disease

  2017cites this paper
• Activated protein C binds directly to Tie2: possible beneficial effects on endothelial barrier function

  2017cites this paper
• The differential expression of protease activated receptors contributes to functional differences between dark and fair keratinocytes.

  2017cites this paper
• Endothelial protein C receptor is overexpressed in colorectal cancer as a result of amplification and hypomethylation of chromosome 20q

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• The Endothelial Protein C Receptor Is a Potential Stem Cell Marker for Epidermal Keratinocytes

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• Glycosaminoglycans in Wound Healing

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  2015cites this paper
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• Treatment of chronic diabetic lower leg ulcers with activated protein C: a randomised placebo‐controlled, double‐blind pilot clinical trial

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• [Peptide-agonist of protease-activated receptor (PAR 1), similar to activated protein C, promotes proliferation in keratinocytes and wound healing of epithelial layer].

  2014cites this paper
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• Activated Protein C Enhances Human Keratinocyte Barrier Integrity via Sequential Activation of Epidermal Growth Factor Receptor and Tie2*

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• Structure and Function of the Endothelial Cell Protein C Receptor

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• Activated protein C mediates a healing phenotype in cultured tenocytes

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