Paraoxonase‐2: A potential biomarker for skin cancer aggressiveness

Cutaneous neoplasms include melanoma and non‐melanoma skin cancers (NMSCs). Among NMSCs, basal cell carcinoma (BCC) represents the most common lesion. On the contrary, although accounting for less than 5% of all skin cancers, melanoma is responsible for most of cutaneous malignancy‐related deaths. Paraoxonase‐2 (PON2) is an intracellular enzyme exerting a protective role against production of reactive oxygen species within mitochondrial respiratory chain. Recently, a growing attention has been focused on exploring the role of PON2 in cancer. The aim of this study was to investigate the diagnostic and prognostic role of PON2 in skin neoplasms.

• Publication year

  2020

• Venue

  European Journal of Clinical Investigation

• Publication date

  2020-11-19

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/eci.13452PMID 33210737
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Bladder Cancer Chemosensitivity Is Affected by Paraoxonase-2 Expression

  2020cited by this paper
• Current and Future Trends in Molecular Biomarkers for Diagnostic, Prognostic, and Predictive Purposes in Non-Melanoma Skin Cancer

  2020cited by this paper
• The clinical and prognostic significance of paraoxonase-2 in gastric cancer patients: immunohistochemical analysis

  2019cited by this paper
• Nicotinamide N‐methyltransferase in nonmelanoma skin cancers

  2019cited by this paper
• Non Melanoma Skin Cancer Pathogenesis Overview

  2018cited by this paper
• Melanoma treatment: from conventional to nanotechnology

  2018cited by this paper
• Paraoxonase 2 overexpression inhibits tumor development in a mouse model of ovarian cancer

  2018cited by this paper
• Histology of Non-Melanoma Skin Cancers: An Update

  2017cited by this paper
• Exploring the role of Paraoxonase-2 in bladder cancer: analyses performed on tissue samples, urines and cell culturess

  2017cited by this paper
• Dermatologist-level classification of skin cancer with deep neural networks

  2017cited by this paper
• Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport.

  2017cited by this paper
• Paraoxonase-2 (PON2) protects oral squamous cell cancer cells against irradiation-induced apoptosis

  2015cited by this paper
• Diagnostic and prognostic biomarkers in melanoma.

  2014cited by this paper
• Breaking the chain at the membrane: paraoxonase 2 counteracts lipid peroxidation at the plasma membrane

  2014cited by this paper
• Basal cell carcinoma – diagnosis

  2013cited by this paper
• The Human Paraoxonase Gene Cluster As a Target in the Treatment of Atherosclerosis

  2012cited by this paper
• Paraoxonase 2 Deficiency Alters Mitochondrial Function and Exacerbates the Development of Atherosclerosis

  2011cited by this paper
• Beyond reduction of atherosclerosis: PON2 provides apoptosis resistance and stabilizes tumor cells

  2011cited by this paper
• A catalogue of reporting guidelines for health research

  2010cited by this paper
• One Enzyme, Two Functions

  2010cited by this paper
• Skin cancer of the head and neck.

  2010cited by this paper
• Skin Cancer: New Markers for Better Prevention

  2009cited by this paper
• Abstract 1608: Paraoxonase 2 Deficiency Alters Mitochondrial Function and Exacerbates the Development of Atherosclerosis

  2009cited by this paper
• Paraoxonase-2 Reduces Oxidative Stress in Vascular Cells and Decreases Endoplasmic Reticulum Stress–Induced Caspase Activation

  2007cited by this paper
• Immunophenotypic analysis of inflammatory breast cancers: identification of an ‘inflammatory signature’

  2004cited by this paper
• Paraoxonase-2 Is a Ubiquitously Expressed Protein with Antioxidant Properties and Is Capable of Preventing Cell-mediated Oxidative Modification of Low Density Lipoprotein*

  2001cited by this paper
• Infiltrative basal cell carcinoma: a nonsclerosing subtype.

  1986cited by this paper

• Role of paraoxonase 2 (PON2) as a potential biomarker and therapeutic target in cancer treatment

  2025cites this paper
• The Paraoxonase (PON) Gene Family in Health, Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) and Other Diseases

  2025cites this paper
• Diagnostic utility of p53, SMAD4, and the novel biomarker PON2 in FNA of pancreatic ductal adenocarcinoma

  2025cites this paper
• Melanoma Skin Cancer: A Comprehensive Review of Current Knowledge

  2025cites this paper
• Contribution of the Paraoxonase-2 Enzyme to Cancer Cell Metabolism and Phenotypes

  2024cites this paper
• Proteomic Analysis Highlights the Impact of the Sphingolipid Metabolizing Enzyme β-Galactosylceramidase on Mitochondrial Plasticity in Human Melanoma

  2024cites this paper
• Pathophysiology, Histopathology, and Differential Diagnostics of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma—An Update from the Pathologist’s Point of View

  2024cites this paper
• An integrated machine learning-based model for joint diagnosis of ovarian cancer with multiple test indicators

  2024cites this paper
• Comparative quantitative proteomic analysis of melanoma subtypes, nevus-associated melanoma, and corresponding nevi.

  2024cites this paper
• Oxidative Stress in Melanoma: Beneficial Antioxidant and Pro-Oxidant Therapeutic Strategies

  2023cites this paper
• Paraoxonase 2 (PON2) plays a limited role in murine lung tumorigenesis

  2023cites this paper
• Potential drug–drug interactions with mitogen-activated protein kinase (MEK) inhibitors used to treat melanoma

  2023cites this paper
• Modulation of paraoxonase-2 in human dermal fibroblasts by UVA-induced oxidative stress: A new potential marker of skin photodamage.

  2023cites this paper
• Reactive Oxygen Species and NRF2 Signaling, Friends or Foes in Cancer?

  2023cites this paper
• Paraoxonase-2 is upregulated in triple negative breast cancer and contributes to tumor progression and chemoresistance

  2023cites this paper
• RHOA G17V induces T follicular helper cell specification and involves angioimmunoblastic T-cell lymphoma via upregulating the expression of PON2 through an NF-κB-dependent mechanism

  2022cites this paper
• Insights into the role of paraoxonase 2 in human pathophysiology

  2022cites this paper
• Insights into the role of paraoxonase 2 in human pathophysiology

  2022cites this paper
• Application of Approved Cisplatin Derivatives in Combination Therapy against Different Cancer Diseases

  2022cites this paper
• The Double-Edged Sword of Oxidative Stress in Skin Damage and Melanoma: From Physiopathology to Therapeutical Approaches

  2022cites this paper
• The Lysosome in Malignant Melanoma: Biology, Function and Therapeutic Applications

  2022cites this paper
• Non-Melanoma Skin Cancer: A Genetic Update and Future Perspectives

  2022cites this paper
• CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR‐30a‐3p and promoting PON2

  2022cites this paper
• Natural and synthetic compounds in Ovarian Cancer: a focus on NRF2/KEAP1 pathway.

  2022cites this paper
• Advances in Management and Therapeutics of Cutaneous Basal Cell Carcinoma

  2022influential citation
• Pathology of Urologic Cancers

  2022cites this paper
• Molecular Mechanisms and Targeted Therapies of Advanced Basal Cell Carcinoma

  2022cites this paper
• Effects of Antioxidant Gene Overexpression on Stress Resistance and Malignization In Vitro and In Vivo: A Review

  2022cites this paper
• Role Played by Paraoxonase-2 Enzyme in Cell Viability, Proliferation and Sensitivity to Chemotherapy of Oral Squamous Cell Carcinoma Cell Lines

  2022cites this paper
• Redox Regulation of Autophagy in Cancer: Mechanism, Prevention and Therapy

  2022cites this paper
• Association between human paraoxonase 2 protein and efficacy of acetylcholinesterase inhibiting drugs used against Alzheimer’s disease

  2021cites this paper
• PON2 blockade overcomes dexamethasone resistance in acute lymphoblastic leukemia

  2021cites this paper
• Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment

  2021cites this paper
• Human Paraoxonase-2 (PON2): Protein Functions and Modulation

  2021cites this paper
• Beyond Nicotinamide Metabolism: Potential Role of Nicotinamide N-Methyltransferase as a Biomarker in Skin Cancers

  2021cites this paper
• Differential immunohistochemical expression of paraoxonase-2 in actinic keratosis and squamous cell carcinoma

  2021cites this paper
• Paraoxonase-2 Silencing Enhances Sensitivity of A375 Melanoma Cells to Treatment with Cisplatin

  2020cites this paper