PAR2 induces ovarian cancer cell motility by merging three signalling pathways to transactivate EGFR

Yuhong Jiang,Junxian Lim,Kai-Chen Wu,Weijun Xu,J. Suen,D. Fairlie

Published 2020 in British Journal of Pharmacology

ABSTRACT

Specific cellular functions mediated by GPCRs are often associated with signalling through a particular G protein or β‐arrestin. Here, we examine signalling through a GPCR, protease‐activated receptor 2 (PAR2), in a high‐grade serous ovarian cancer cell line (OV90).

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