Macrolactam Synthesis via Ring-Closing Alkene-Alkene Cross-Coupling Reactions.

Reported herein is a practical method for macrolactam synthesis via a Rh(III)-catalyzed ring closing alkene-alkene cross-coupling reaction. The reaction proceeded via a Rh-catalyzed alkenyl sp2 C-H activation process, which allows access to macrocyclic molecules of different ring sizes. Macrolactams containing a conjugated diene framework could be easily prepared in high chemoselectivities and Z,E stereoselectivities.

• Publication year

  2020

• Venue

  Organic Letters

• Publication date

  2020-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.orglett.0c03801PMID 33258611
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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