Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans

No abstract is available for this paper.

• Publication year

  2003

• Venue

  The FASEB Journal

• Publication date

  2003-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1096/fj.02-1022fjePMID 12709403
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity

  2003cited by this paper
• Coenzyme Q10 as a possible treatment for neurodegenerative diseases.

  2002cited by this paper
• Endogenous oxidative stress: relationship to aging, longevity and caloric restriction.

  2002cited by this paper
• Quinones in long‐lived clk‐1 mutants of Caenorhabditis elegans

  2002cited by this paper
• Ubiquinone Is Necessary for Caenorhabditis elegansDevelopment at Mitochondrial and Non-mitochondrial Sites*

  2002cited by this paper
• Mechanisms of aging: an appraisal of the oxidative stress hypothesis.

  2002cited by this paper
• Regulatory Aspects of Coenzyme Q Metabolism

  2002cited by this paper
• Uptake of Exogenous Coenzyme Q and Transport to Mitochondria Is Required for bc 1 Complex Stability in Yeastcoq Mutants*

  2002cited by this paper
• Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q

  2002influential reference
• Altered Quinone Biosynthesis in the Long-lived clk-1Mutants of Caenorhabditis elegans *

  2001cited by this paper
• A New Member of the Family of Di-iron Carboxylate Proteins

  2001cited by this paper
• A cue to queue for CoQ?

  2001cited by this paper
• A Defect in the Cytochrome b Large Subunit in Complex II Causes Both Superoxide Anion Overproduction and Abnormal Energy Metabolism in Caenorhabditis elegans *

  2001cited by this paper
• Ubiquinone Is Necessary for Mouse Embryonic Development but Is Not Essential for Mitochondrial Respiration*

  2001cited by this paper
• A dietary source of coenzyme Q is essential for growth of long-lived Caenorhabditis elegans clk-1 mutants.

  2001cited by this paper
• A Defect in Coenzyme Q Biosynthesis Is Responsible for the Respiratory Deficiency in Saccharomyces cerevisiae abc1Mutants*

  2001cited by this paper
• The OLD-1 positive regulator of longevity and stress resistance is under DAF-16 regulation in Caenorhabditis elegans.

  2001cited by this paper
• Coenzyme Q: Molecular Mechanisms in Health and Disease

  2001cited by this paper
• Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans.

  2001cited by this paper
• Genetic pathways that regulate ageing in model organisms

  2000cited by this paper
• Genetic evidence for a multi-subunit complex in the O-methyltransferase steps of coenzyme Q biosynthesis.

  2000cited by this paper
• Coenzyme Q is an obligatory cofactor for uncoupling protein function

  2000cited by this paper
• Yeast and Rat Coq3 and Escherichia coli UbiG Polypeptides Catalyze Both O-Methyltransferase Steps in Coenzyme Q Biosynthesis*

  1999cited by this paper
• A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants

  1999cited by this paper
• Localization and mobility of coenzyme Q in lipid bilayers and membranes

  1999cited by this paper
• Vitamin E and selenium deficiency induces expression of the ubiquinone‐dependent antioxidant system at the plasma membrane

  1998cited by this paper
• Yeast Clk-1 Homologue (Coq7/Cat5) Is a Mitochondrial Protein in Coenzyme Q Synthesis*

  1998cited by this paper
• A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes

  1998cited by this paper
• Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

  1998cited by this paper
• RNAi in C. elegans: Soaking in the Genome Sequence

  1998cited by this paper
• Specific interference by ingested dsRNA

  1998cited by this paper
• RNAi in C. elegans: soaking in the genome sequence.

  1998cited by this paper
• The ispB gene encoding octaprenyl diphosphate synthase is essential for growth of Escherichia coli

  1997cited by this paper
• Structural and Functional Conservation of the Caenorhabditis elegans Timing Gene clk-1

  1997cited by this paper
• Determination of manganese superoxide dismutase activity by direct spectrophotometry.

  1996cited by this paper
• The COQ7 Gene Encodes a Protein in Saccharomyces cerevisiae Necessary for Ubiquinone Biosynthesis (*)

  1996cited by this paper
• Assessment of mitochondrial oxidative phosphorylation in patient muscle biopsies, lymphoblasts, and transmitochondrial cell lines.

  1996cited by this paper
• Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing.

  1995cited by this paper
• Aging and resistance to oxidative damage in Caenorhabditis elegans.

  1993cited by this paper
• COQ2 is a candidate for the structural gene encoding para-hydroxybenzoate:polyprenyltransferase.

  1992cited by this paper
• PET genes of Saccharomyces cerevisiae.

  1990cited by this paper

• Modelling the human Coenzyme Q deficiency in Drosophila melanogaster.

  2025cites this paper
• Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans

  2024cites this paper
• Evolutionarily related host and microbial pathways regulate fat desaturation

  2023cites this paper
• A miniaturized nigrostriatal-like circuit regulating locomotor performance in a protochordate.

  2023cites this paper
• Genetic and Chemical Controls of Sperm Fate and Spermatocyte Dedifferentiation via PUF-8 and MPK-1 in Caenorhabditis elegans

  2023cites this paper
• A gut commensal bacterium promotes black soldier fly larval growth and development partly via modulation of intestinal protein metabolism

  2023cites this paper
• Coenzyme Q homeostasis in aging: response to non-genetic interventions.

  2021cites this paper
• Coenzyme Q Biosynthesis Disorders

  2021cites this paper
• The Aging Process and Coenzyme Q: Clk-1 Mouse Models

  2020cites this paper
• Caloric Restriction, Longevity and Coenzyme Q

  2020cites this paper
• Coenzyme Q and Aging in C. elegans

  2020cites this paper
• Coenzyme Q10 supplementation in aging

  2020cites this paper
• Coenzyme Q in Aging

  2020cites this paper
• The Paradox of Coenzyme Q10 in Aging

  2019cites this paper
• Gap junction-dependent coordination of intercellular calcium signalling in the developing appendicularian tunicate Oikopleura dioica.

  2019cites this paper
• Development of the house secreting epithelium, a major innovation of tunicate larvaceans, involves multiple homeodomain transcription factors.

  2018cites this paper
• Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis

  2018cites this paper
• Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases.

  2018cites this paper
• Coenzyme Q and Its Role in the Dietary Therapy against Aging

  2016cites this paper
• Mitochondrial form, function and signalling in aging.

  2016cites this paper
• RNA-binding proteins regulate cell respiration and coenzyme Q biosynthesis by post-transcriptional regulation of COQ7

  2016cites this paper
• Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

  2016cites this paper
• Mitochondrial responsibility in ageing process: innocent, suspect or guilty

  2015cites this paper
• Dietary restriction decreases coenzyme Q and ubiquinol potentially via changes in gene expression in the model organism C. elegans.

  2015cites this paper
• Modification of the larval swimming behavior in Oikopleura dioica, a chordate with a miniaturized central nervous system by dsRNA injection into fertilized eggs.

  2015cites this paper
• Remodeling and Pulmonary Hypertension Reticulum Stress on Mitochondria and Triggers Pseudohypoxic Pulmonary Vascular Uncoupling Protein 2 Deficiency Mimics the Effects of Hypoxia and Endoplasmic

  2015cites this paper
• Coenzyme Q10 as a therapy for mitochondrial disease.

  2014cites this paper
• Invertebrate Models for Coenzyme Q10 Deficiency

  2014cites this paper
• Extended lifespan, reduced body size and leg skeletal muscle mass, and decreased mitochondrial function in clk-1 transgenic mice.

  2014cites this paper
• Mitochondrial function in cells, tissues and animals without ubiquinone biosynthesis

  2014cites this paper
• Synergistic Effects of GhSOD1 and GhCAT1 Overexpression in Cotton Chloroplasts on Enhancing Tolerance to Methyl Viologen and Salt Stresses

  2013cites this paper
• Homologous expression of γ-glutamylcysteine synthetase increases grain yield and tolerance of transgenic rice plants to environmental stresses.

  2013cites this paper
• Molecular genetics of ubiquinone biosynthesis in animals

  2013influential citation
• Salt and genotype impact on antioxidative enzymes and lipid peroxidation in two rice cultivars during de-etiolation

  2013cites this paper
• Transgenic rice overexpressing the Brassica juncea gamma-glutamylcysteine synthetase gene enhances tolerance to abiotic stress and improves grain yield under paddy field conditions

  2013cites this paper
• Age and Oxidative Stress in the Germ Line

  2012cites this paper
• Regulation of Polarized Protein Transport to Axons, Dendrites, and Sensory Cilia in Caeborhabditis Elegans Neurons

  2011influential citation
• The mevalonate pathway in C. Elegans

  2011cites this paper
• Amount and activity changes of 20S proteasome modified by oxidation in salt-treated wheat root tips

  2011cites this paper
• The Alterations of Energy Metabolism-related Protein Patterns in Brown Adipose Tissue of Rats During Cold-induced Thermogenesis

  2010cites this paper
• The lipophilic antioxidants alpha-tocopherol and coenzyme Q10 reduce the replicative lifespan of Saccharomyces cerevisiae.

  2010cites this paper
• The Effects of Exogenous Ubiquinone on Mitochondrial Function, Oxidative Damage, and Lifespan in Caenorhabditis elegans

  2010influential citation
• Is coenzyme Q a key factor in aging?

  2010cites this paper
• Coenzyme Q protects Caenorhabditis elegans GABA neurons from calcium-dependent degeneration

  2010cites this paper
• Coenzyme Q10 deficiencies in neuromuscular diseases.

  2009cites this paper
• Biotechnological approach of improving plant salt tolerance using antioxidants as markers.

  2009cites this paper
• Hydroxylation of demethoxy-Q 6 constitutes a control point in yeast coenzyme Q 6

  2009cites this paper
• Coenzyme Q supports distinct developmental processes in Caenorhabditis elegans.

  2009cites this paper
• Biosynthesis and bioproduction of coenzyme Q10 by yeasts and other organisms

  2009cites this paper
• Coenzyme Q9 provides cardioprotection after converting into coenzyme Q10.

  2008cites this paper
• Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells.

  2008cites this paper
• Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis

  2008cites this paper
• The coenzyme Q10 status of the brain regions of Parkinson's disease patients.

  2008cites this paper
• Genetics of Life Span: Lessons from Model Organisms

  2008cites this paper
• Rôle des protéines 14-3-3 dans la régulation de la longévité par la voie DAF-2/Insuline/IGF-1 chez Caenorhabditis elegans

  2008cites this paper
• Coenzyme Q, oxidative stress and aging.

  2007cites this paper
• The antioxidant role of coenzyme Q.

  2007cites this paper
• Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction.

  2007cites this paper
• Differential expression pattern of coq-8 gene during development in Caenorhabditis elegans.

  2006cites this paper
• Coenzyme Q is irreplaceable by demethoxy‐coenzyme Q in plasma membrane of Caenorhabditis elegans

  2006cites this paper
• TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone.

  2006cites this paper
• Chemotherapy induces an increase in coenzyme Q10 levels in cancer cell lines.

  2006cites this paper
• Short communication Cerebellar ataxia with coenzyme Q 10 deficiency: Diagnosis and follow-up after coenzyme Q 10 supplementation

  2006cites this paper
• Stimulation of polyprenyl 4-hydroxybenzoate transferase activity by sodium cholate and 3-[(cholamidopropyl)dimethylammonio]-1-propanesulfonate.

  2006cites this paper
• Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidative defenses, and life span of mice.

  2006cites this paper
• Cerebellar ataxia with coenzyme Q10 deficiency: diagnosis and follow-up after coenzyme Q10 supplementation.

  2006cites this paper
• C. elegans knockouts in ubiquinone biosynthesis genes result in different phenotypes during larval development

  2005cites this paper
• Coenzyme Q distribution in HL-60 human cells depends on the endomembrane system.

  2005cites this paper
• The role of ubiquinone in Caenorhabditis elegans longevity.

  2005cites this paper
• Coenzyme Q and the regulation of intracellular steady‐state levels of superoxide in HL‐60 cells

  2005influential citation
• Determination of coenzyme Q biosynthesis in cultured cells without the necessity for lipid extraction.

  2005cites this paper
• Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing.

  2005influential citation
• Demethoxy-Q, An Intermediate of Coenzyme Q Biosynthesis, Fails to Support Respiration in Saccharomyces cerevisiae and Lacks Antioxidant Activity*

  2004cites this paper
• Metabolism and function of coenzyme Q.

  2004cites this paper
• coq7/clk‐1 regulates mitochondrial respiration and the generation of reactive oxygen species via coenzyme Q

  2004influential citation
• Emerging technologies: trendy RNA tools for aging research.

  2004cites this paper
• Understanding aging: revealing order out of chaos.

  2004cites this paper
• Caenorhabditis elegans ubiquinone biosynthesis genes

  2003cites this paper
• Alternative respiration in seven Quercus Spp. of SW Spain

  2003cites this paper
• Anti-Aging Medicine LiteratureWatch

  2003cites this paper