Comparison of QT peak and QT end interval responses to autonomic adaptation in asymptomatic LQT1 mutation carriers

Background:  LQT1 subtype of long QT syndrome is characterized by defective IKs, which is intrinsically stronger in the epicardium than in the midmyocardial region. Electrocardiographic QT peak and QT end intervals may reflect complete repolarization of epicardium and midmyocardial region of the ventricular wall, respectively. Repolarization abnormalities in LQT1 carriers may therefore be more easily detected in the QT peak intervals.

• Publication year

  2011

• Venue

  Clinical Physiology and Functional Imaging

• Publication date

  2011-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1111/j.1475-097X.2010.01002.xPMID 21138517PMCID 3121965
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1998influential reference
• Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

  1996cited by this paper
• Characteristics of the delayed rectifier current (IKr and IKs) in canine ventricular epicardial, midmyocardial, and endocardial myocytes. A weaker IKs contributes to the longer action potential of the M cell.

  1995cited by this paper
• Cardiac repolarization properties during standardized exercise test as studied by QT, QT peak and terminated T-wave intervals.

  1989cited by this paper
• The QT interval during reflex cardiovascular adaptation.

  1984cited by this paper
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  year unknowncited by this paper

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