Enhanced 5-fluorouracil cytotoxicity in high COX-2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Biochemistry and cell biology = Biochimie et biologie cellulaire

• Publication date

  Unknown publication date

• Fields of study

  Medicine

• Identifiers
  DOI 10.1139/bcb-2012-0077PMID 23859016
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Association of cyclooxygenase 2 single-nucleotide polymorphisms and hepatocellular carcinoma in Taiwan.

  2012cited by this paper
• Anti-cancer natural products isolated from chinese medicinal herbs

  2011cited by this paper
• Treatment Options in Hepatocellular Carcinoma Today

  2011cited by this paper
• Retrospective comparison between a regular and a split-dose protocol of 5-fluorouracil, cisplatin, and mitoxantrone for the treatment of far advanced hepatocellular carcinoma

  2011cited by this paper
• Down-regulation of PKHD1 induces cell apoptosis through PI3K and NF-κB pathways.

  2011cited by this paper
• Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains

  2010cited by this paper
• Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells

  2010cited by this paper
• Synergistic effect of celecoxib on 5-fluorouracil-induced apoptosis in hepatocellular carcinoma patients.

  2010cited by this paper
• Reactive oxygen species up‐regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin

  2009cited by this paper
• Treatment of hepatocellular carcinoma using arterial chemoembolization with degradable starch microspheres and continuous arterial infusion of 5-fluorouracil.

  2008cited by this paper
• Rare sugar D-allose enhances anti-tumor effect of 5-fluorouracil on the human hepatocellular carcinoma cell line HuH-7.

  2008cited by this paper
• Choline kinase down-regulation increases the effect of 5-fluorouracil in breast cancer cells.

  2007cited by this paper
• Cyclooxygenase-2 (COX-2)--a therapeutic target in liver cancer?

  2007cited by this paper
• Wogonin prevents glucocorticoid-induced thymocyte apoptosis without diminishing its anti-inflammatory action.

  2007cited by this paper
• Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis.

  2006cited by this paper
• Theoretical Basis, Experimental Design, and Computerized Simulation of Synergism and Antagonism in Drug Combination Studies

  2006cited by this paper
• Cyclooxygenase-2 in hepatocellular carcinoma.

  2006cited by this paper
• Cyclooxygenase-2 inhibition induces apoptosis signaling via death receptors and mitochondria in hepatocellular carcinoma.

  2006cited by this paper
• Combination therapy of intraarterial 5‐fluorouracil and systemic interferon‐alpha for advanced hepatocellular carcinoma with portal venous invasion

  2006cited by this paper
• Anti-hepatocarcinoma effects of 5-fluorouracil encapsulated by galactosylceramide liposomes in vivo and in vitro.

  2005cited by this paper
• Overexpression of cyclooxygenase-2 in human HepG2, Bel-7402 and SMMC-7721 hepatoma cell lines and mechanism of cyclooxygenase-2 selective inhibitor celecoxib-induced cell growth inhibition and apoptosis.

  2005cited by this paper
• Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast.

  2005cited by this paper
• Successful treatment of advanced hepatocellular carcinoma by combined administration of 5-fluorouracil and pegylated interferon-alpha.

  2005cited by this paper
• Promoter hypermethylation silences cyclooxygenase-2 (Cox-2) and regulates growth of human hepatocellular carcinoma cells

  2004cited by this paper
• YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-kappaB in human pulmonary epithelial cells.

  2004cited by this paper
• Signaling to NF-kappaB.

  2004cited by this paper
• Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.

  2004cited by this paper
• Cyclooxygenase‐2 modulates cellular growth and promotes tumorigenesis

  2003cited by this paper
• Potential role of selective COX-2 inhibitors in cancer management.

  2002cited by this paper
• Expression of cyclooxygenase-2 (COX-2) in hepatocellular carcinoma and growth inhibition of hepatoma cell lines by a COX-2 inhibitor, NS-398.

  2001cited by this paper
• Cyclooxygenase-2 Expression Inhibits Trophic Withdrawal Apoptosis in Nerve Growth Factor-differentiated PC12 Cells*

  2000cited by this paper
• Cyclooxygenase-2 expression in hepatocellular carcinoma.

  1999cited by this paper
• Expression of cyclooxygenase‐2 in human hepatocellular carcinoma: Relevance to tumor dedifferentiation

  1999cited by this paper
• Cyclooxygenase in biology and disease

  1998cited by this paper
• Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors.

  1984cited by this paper

• The Role of Natural Products in Liver Cancer: Focus on Angiogenesis, Inflammation, Oxidative Stress, and Apoptosis

  2025cites this paper
• Sangju Yin and Delta Variant—Potential Mechanism of Sangju Yin for the Treating Delta Variant Based on Network Pharmacology and Molecular Docking

  2023cites this paper
• Wogonin inhibits hepatoma cell proliferation by targeting miR‐27b‐5p/YWHAZ axis

  2023cites this paper
• Wogonin, as a potent anticancer compound: From chemistry to cellular interactions

  2023cites this paper
• Potential mechanism of action of Jing Fang Bai Du San in the treatment of COVID-19 using docking and network pharmacology

  2022cites this paper
• Phytochemicals and Nanoparticles in the Modulation of PI3K/ Akt/ mTOR Kinases and Its Implications in the Development and Progression of Gastrointestinal Cancers: A Review of Preclinical and Clinical Evidence.

  2022cites this paper
• Wogonin and its analogs for the prevention and treatment of cancer: A systematic review

  2022cites this paper
• Drug-herb interactions between Scutellaria baicalensis and pharmaceutical drugs: Insights from experimental studies, mechanistic actions to clinical applications.

  2021cites this paper
• Network Pharmacology-Based Study on the Mechanism of Scutellariae Radix for Hepatocellular Carcinoma Treatment

  2020cites this paper
• Fascinating chemo preventive story of wogonin: A chance to hit on the head in cancer treatment.

  2020cites this paper
• Wogonin Increases Cisplatin Sensitivity in Ovarian Cancer Cells Through Inhibition of the Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway

  2019cites this paper
• Identification of a 3,3-difluorinated tetrahydropyridinol compound as a novel antitumor agent for hepatocellular carcinoma acting via cell cycle arrest through disturbing CDK7-mediated phosphorylation of Cdc2

  2019cites this paper
• Polyphenols of Chinese skullcap roots: from chemical profiles to anticancer effects

  2019cites this paper
• Flavonoids Effects on Hepatocellular Carcinoma in Murine Models: A Systematic Review

  2018cites this paper
• COX-2/PGE2 Axis Regulates HIF2α Activity to Promote Hepatocellular Carcinoma Hypoxic Response and Reduce the Sensitivity of Sorafenib Treatment

  2018cites this paper
• Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways.

  2017cites this paper
• Low-dose 5-fluorouracil sensitizes HepG2 cells to TRAIL through TRAIL receptor DR5 and survivin-dependent mechanisms

  2017cites this paper
• Advances of wogonin, an extract from Scutellaria baicalensis, for the treatment of multiple tumors

  2016cites this paper
• Overview of Oroxylin A: A Promising Flavonoid Compound

  2016cites this paper
• Targeting arachidonic acid pathway by natural products for cancer prevention and therapy.

  2016cites this paper
• DNA-PKcs deficiency sensitizes the human hepatoma HepG2 cells to cisplatin and 5-fluorouracil through suppression of the PI3K/Akt/NF-κB pathway

  2014cites this paper
• miR‐137 effects on gastric carcinogenesis are mediated by targeting Cox‐2‐activated PI3K/AKT signaling pathway

  2014cites this paper
• Cytostatic/Cytotoxic Effects of 5‐Fluorouridine Nucleolipids on Colon, Hepatocellular, and Renal Carcinoma Cells: in vitro Identification of a Potential Cytotoxic Multi‐Anticancer Drug

  2014cites this paper
• Oncotargets and Therapy Dovepress Dovepress Her2 Induces Cell Proliferation and Invasion of Non-small-cell Lung Cancer by Upregulating Cox-2 Expression via Mek/erk Signaling Pathway

  year unknowncites this paper